| 胡德强,徐卫华,陈 婷,刘利梅,张奇武.醒脾养儿颗粒联合双歧杆菌三联活菌散对轮状病毒腹泻患儿免疫功能、心肌酶指标和血清 IL-6、CRP的影响[J].现代生物医学进展英文版,2022,(6):1147-1150. |
| 醒脾养儿颗粒联合双歧杆菌三联活菌散对轮状病毒腹泻患儿免疫功能、心肌酶指标和血清 IL-6、CRP的影响 |
| Effects of Xingpi Yanger Granule Combined with Bifidobacterium Triple Viable Powder on Immune Function, Myocardial Enzyme Indexes, Serum IL-6 and CRP in Children with Rotavirus Diarrhea |
| Received:July 29, 2021 Revised:August 24, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.06.031 |
| 中文关键词: 醒脾养儿颗粒 双歧杆菌三联活菌散 轮状病毒腹泻 免疫功能 心肌酶指标 IL-6 CRP |
| 英文关键词: Xingpi Yanger granule Bifidobacterium triple viable powder Rotavirus diarrhea Immune function Myocardial enzyme index IL-6 CRP |
| 基金项目:安徽省重点研究和开发计划项目（1804h08020285） |
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| 中文摘要: |
| 摘要 目的：观察醒脾养儿颗粒联合双歧杆菌三联活菌散对轮状病毒腹泻患儿免疫功能、心肌酶指标和血清白介素 -6（IL-6）、C反应蛋白（CRP）的影响。方法：选取 2018年 1月到 2021年 1月期间我院接收的 92例轮状病毒腹泻患儿。根据随机数字表法将患儿分为对照组和研究组，各为 46例。对照组患儿接受双歧杆菌三联活菌散治疗，研究组患儿接受醒脾养儿颗粒联合双歧杆菌三联活菌散治疗，均治疗 3 d。观察两组疗效，记录不良反应发生情况。观察并对比两组患儿免疫功能[免疫球蛋白（Ig）M、IgG和 IgA]、心肌酶指标[磷酸肌酸激酶（CK）、乳酸脱氢酶（LDH）、肌酸激酶同工酶（CK-MB）]和血清 IL-6、CRP的变化情况。结果：研究组的临床总有效率为 91.30%（42/46），高于对照组患者的 71.74%（33/46），差异有统计学意义（P<0.05）。两组治疗 3 d后血清 IgM、IgG、IgA水平较治疗前升高，且研究组的改善程度优于对照组（P<0.05）。两组治疗 3 d后血清 LDH、CK、CK-MB水平较治疗前降低，且研究组的改善程度优于对照组（P<0.05）。两组治疗 3 d后血清 IL-6、CRP水平较治疗前降低，且研究组的改善程度优于对照组（P<0.05）。两组患儿均未见明显不良反应发生。结论：醒脾养儿颗粒联合双歧杆菌三联活菌散治疗轮状病毒腹泻患儿，可提高免疫力，减轻心肌损伤，降低血清 IL-6、CRP水平，安全有效。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of Xingpi Yanger granule combined with Bifidobacterium triple viable powder on immune function, myocardial enzyme indexes, serum interleukin-6(IL-6) and C-reactive protein(CRP) in children with rotavirus diarrhea. Methods: 92 children with rotavirus diarrhea who were received in our hospital from January 2018 to January 2021 were selected. According to the random number table method, the children were divided into control group and study group, with 46 cases in each group. The children in the control group were treated with Bifidobacterium triple viable powder, and the children in the study group were treated with Xingpi Yanger granule combined with Bifidobacterium triple viable powder, all patients were treated for 3 days. The curative effects of the two groups were observed and the adverse reactions were recorded. The changes of immune function [immunoglobulin (Ig) m, IgG and IgA], myocardial enzyme indexes [phosphocreatine kinase (CK), lactate dehydrogenase (LDH), creatine kinase isoenzyme (CK-MB)] and serum IL-6 and CRP were observed and compared between the two groups. Results: The total clinical effective rate in the study group was 91.30% (42/46), which was higher than 71.74% (33/46) in the control group (P<0.05). The levels of serum IgM, IgG and IgA in the two groups were higher than those before treatment, and the improvement degree of the study group was better than that of the control group (P<0.05). The levels of serum LDH, CK and CK-MB in the two groups were lower than those before treatment, and the improvement degree of the study group was better than that of the control group (P<0.05). The levels of serum IL-6 and CRP in the two groups were lower than those before treatment, and the improvement degree of the study group was better than that of the control group (P<0.05). There were no significant adverse reactions in both groups. Conclusion: Xingpi Yanger granule combined with Bifidobacterium triple viable powder in the treatment of children with rotavirus diarrhea can improve immunity, reduce myocardial injury and reduce the levels of serum IL-6 and CRP, which is safe and effective. |
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