| 武 祎,刘梅梅,刘双岭,赵桂君,金 成.补脾滋肾汤联合针灸治疗多囊卵巢综合征不孕症的临床疗效观察[J].现代生物医学进展英文版,2022,(6):1107-1111. |
| 补脾滋肾汤联合针灸治疗多囊卵巢综合征不孕症的临床疗效观察 |
| Clinical Observation of Bupi Zishen Decoction Combined with Acupuncture in Treating Infertility with Polycystic Ovary Syndrome |
| Received:October 08, 2021 Revised:October 30, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.06.023 |
| 中文关键词: 补脾滋肾汤 针灸 多囊卵巢综合征 不孕症 |
| 英文关键词: Bupi Zishen decoction Acupuncture Polycystic Ovary Syndrome Infertility |
| 基金项目:吴阶平医学基金会临床科研专项基金项目（320.6750.18542）；黑龙江省中医药管理局科研项目（ZHY18-008） |
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| 中文摘要: |
| 摘要 目的：观察补脾滋肾汤联合针灸治疗多囊卵巢综合征（PCOS）不孕症的临床疗效。方法：选择2018年9月~2020年9月就诊的120例PCOS不孕症患者，随机分为观察组和对照组各60例。均给予口服枸橼酸氯米芬基础治疗，观察组在基础治疗上增加补脾滋肾汤联合针灸治疗，28 d为一个治疗周期，对比两组患者3个疗程后总有效率、中医证候量表评分、BMI（体质量指数）、月经情况、排卵情况、妊娠情况、血清性激素指标[T（睾酮）、LH（促黄体生成激素）、FSH（促卵泡生成激素）]、B超测定子宫内膜容受性指标[子宫内膜厚度、PI（子宫内膜螺旋动脉搏动指数）与RI（阻力指数）]。结果：治疗3个疗程后观察组的临床总有效率为90%（54/60），高于对照组的83%（50/60）（P<0.05）。经过3个疗程治疗后，两组PCOS不孕症患者中医症候量表评分改善，月经情况改善，两组排卵率、妊娠率提高，且观察组高于对照组（P<0.05）。治疗3个疗程后，两组BMI、RI、PI、LH、T均下降，且观察组低于对照组（P<0.05）；两组子宫内膜厚度、FSH均增高，且观察组高于对照组（P<0.05）。结论：补脾滋肾汤联合针灸治疗多囊卵巢综合征不孕患者通过中药滋补脾肾、针灸治疗后，有效缓解了临床症状，性激素水平得到调节、体重减轻，提高调经促排卵助孕率，疗效确切。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the clinical effect of Bupi Zishen decoction combined with acupuncture on infertility with polycystic ovary syndrome (PCOS). Methods: A total of 120 PCOS infertility patients admitted from September 2018 to September 2020 were selected and randomly divided into observation group and control group (60 cases in each group). All patients were given oral clomiphene citrate basic treatment, and the observation group was added to the basic treatment with Bupi Zishen decoction combined with acupuncture, with 28 d as a treatment cycle. Compared two groups of patients after 3 course of total effective rate, TCM syndrome scale score, BMI (body mass index), menstruation, ovulation, pregnancy, serum sex hormone index [T(testosterone), LH (luteinizing hormone), FSH (follicle-stimulating hormone)], B ultrasonic measurement and the receptivity of endometrium index [endometrial thickness, PI (endometrial screw Rotary pulse index) and RI (resistance index)]. Results: After 3 courses of treatment, the total effective rate in the observation group was 90% (54/60), which was higher than that in the control group (83% (50/60))(P<0.05). After 3 courses of treatment, TCM syndrome scale scores of PCOS infertility patients in the two groups improved, menstrual situation improved, ovulation rate and pregnancy rate in the two groups increased, and the observation group was higher than the control group (P<0.05). After 3 courses of treatment, BMI, RI, PI, LH and T in both groups decreased, and the observation group was lower than the control group(P<0.05). Endometrial thickness and FSH were increased in both groups, and the observation group was higher than the control group(P<0.05). Conclusion: The treatment of infertility patients with polycystic ovary syndrome by Bupi Bupi Zishen decoction combined with acupuncture can relieve the clinical symptoms, regulate the level of sex hormones, reduce body weight, improve the rate of menstruation regulation, ovulation promotion and pregnancy, and has definite curative effect. |
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