| 鲍爱利,梁 婧,邵 超,李伟华,吴 熙.丹黄祛瘀胶囊联合阿奇霉素对慢性盆腔炎患者血液流变学和血清炎症因子的影响[J].现代生物医学进展英文版,2022,(6):1060-1063. |
| 丹黄祛瘀胶囊联合阿奇霉素对慢性盆腔炎患者血液流变学和血清炎症因子的影响 |
| Effects of Danhuang Quyu Capsule Combined with Azithromycin on Hemorheology and Serum Inflammatory Factors in Patients with Chronic Pelvic Inflammatory Disease |
| Received:August 21, 2021 Revised:September 17, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.06.013 |
| 中文关键词: 丹黄祛瘀胶囊 阿奇霉素 慢性盆腔炎 血液流变学 炎症因子 |
| 英文关键词: Danhuang Quyu capsule Azithromycin Chronic pelvic inflammatory disease Hemorheology Inflammatory factor |
| 基金项目:北京市自然科学基金项目（7182141）；吴阶平医学基金会临床科研专项基金（320.6750.18458） |
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| 中文摘要: |
| 摘要 目的：观察阿奇霉素联合丹黄祛瘀胶囊在慢性盆腔炎患者中的应用价值。方法：研究病例选自2019年6月至2021年6月期间我院收治的慢性盆腔炎患者127例，采用随机数字表法将符合要求的患者分为对照组（63例，阿奇霉素治疗）和观察组（64例，丹黄祛瘀胶囊联合阿奇霉素治疗），两组均治疗2周。对比两组疗效、临床症状消失时间、血液流变学和血清炎症因子变化情况，观察两组不良反应的发生情况，并作记录。结果：观察组临床总有效率高于对照组（P<0.05）。观察组的腰骶胀痛、下腹疼痛、带下异常等症状消失时间短于对照组（P<0.05）。观察组治疗2周后的白介素-6（IL-6）、白介素-1β（IL-1β）、C反应蛋白（CRP）低于对照组（P<0.05）。观察组治疗2周后的全血高切黏度、全血低切黏度、纤维蛋白原及红细胞沉降率低于对照组（P<0.05）。两组患者的不良反应发生率组间对比无统计学差异（P>0.05）。结论：慢性盆腔炎在阿奇霉素治疗基础上联合丹黄祛瘀胶囊，症状得到明显缓解，同时还可改善机体血液流变学和炎症因子水平，临床应用价值较好。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the application value of Azithromycin combined with Danhuang Quyu capsule in patients with chronic pelvic inflammatory disease. Methods: 127 patients with chronic pelvic inflammatory disease who were treated in our hospital from June 2019 to June 2021 were selected, they were randomly divided into control group(63 cases, azithromycin treatment) and observation group (64 cases, Danhuang Quyu capsule combined with azithromycin treatment), both groups were treated for 2 weeks. The curative effect, disappearance time of clinical symptoms, hemorheology and changes of serum inflammatory factors were compared between the two groups. The occurrence of adverse reactions in the two groups were observed and recorded. Results: The total effective rate of the observation group was higher than that of the control group(P<0.05). The disappearance time of lumbosacral pain, lower abdominal pain and abnormal band in the observation group were shorter than those in the control group(P<0.05). The levels of interleukin-6 (IL-6), interleukin-1 β（IL-1β）, C-reactive protein (CRP) in the observation group at 2 weeks after treatment were lower than those in the control group(P<0.05). The whole blood high shear viscosity, whole blood low shear viscosity, fibrinogen and erythrocyte sedimentation rate in the observation group at 2 weeks after treatment were lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: On the basis of azithromycin treatment, combined with Danhuang Quyu capsule, the symptoms of chronic pelvic inflammatory disease can be significantly alleviated. At the same time, it can also improve the level of Hemorheology and inflammatory factors. It has good clinical application value. |
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