| 肖 帅,禹 洁,何 杨,李 逦,刘 凌.慢性牙周炎患者牙龈卟啉单胞菌感染与血清HMGB1、IL-1β、IL-6以及牙周临床指标的相关性研究[J].现代生物医学进展英文版,2022,(5):985-989. |
| 慢性牙周炎患者牙龈卟啉单胞菌感染与血清HMGB1、IL-1β、IL-6以及牙周临床指标的相关性研究 |
| Study on the Correlation between Porphyromonas Gingivalis Infection and Serum HMGB1, IL-1β, IL-6 and Periodontal Clinical Indicators in Patients with Chronic Periodontitis |
| Received:August 22, 2021 Revised:September 17, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.05.038 |
| 中文关键词: 慢性牙周炎 牙龈卟啉单胞菌 高迁移率族蛋白1 白细胞介素-1β 白细胞介素-6 |
| 英文关键词: Chronic periodontitis Porphyromonas gingivalis High mobility group protein 1 Interleukin-1β Interleukin-6 |
| 基金项目:湖南省卫生健康委员会科研计划项目（B2017199） |
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| 中文摘要: |
| 摘要 目的：研究慢性牙周炎患者牙龈卟啉单胞菌（Pg）感染与血清高迁移率族蛋白1（HMGB1）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）以及牙周临床指标的相关性。方法：将2019年1月～2020年12月在长沙市第三医院口腔科接受诊治的300例慢性牙周炎患者纳入研究，按照慢性牙周炎严重程度分成轻度组169例、中度组92例、重度组39例。对所有受试者进行Pg检测，同时检测血清HMGB1、IL-1β、IL-6水平和牙周临床指标水平。比较各组上述各项指标的差异，并以Pearson相关性分析慢性牙周炎患者Pg感染与血清HMGB1、IL-1β、IL-6水平以及牙周临床指标的相关性。结果：重度组和中度组的Pg感染阳性率、Pg感染浓度均高于轻度组，且重度组上述指标高于中度组（P＜0.05）。重度组和中度组的血清HMGB1、IL-1β、IL-6水平均高于轻度组，且重度组上述指标高于中度组（P＜0.05）。重度组和中度组的探诊深度（PD）、龈沟出血指数（SBI）以及附着丧失（AL）均高于轻度组，且重度组上述指标高于中度组（P＜0.05）。Pearson相关性分析显示：慢性牙周炎患者的Pg感染浓度与血清HMGB1、IL-1β、IL-6水平以及PD、SBI、AL均呈正相关（P＜0.05)。结论：慢性牙周炎患者的Pg感染浓度与血清HMGB1、IL-1β、IL-6水平及牙周健康状况密切相关，早期明确Pg感染浓度以及检测上述血清学指标水平，可能对抑制病程进展以及提高治疗效果具有指导意义。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between porphyromonas gingivalis (Pg) infection and serum high mobility group protein 1 (HMGB1), interleukin-1β (IL-1β), interleukin-6 (IL-6) and periodontal clinical indicators in patients with chronic periodontitis. Methods: 300 patients with chronic periodontitis treated in Department of Dental, Changsha Third Hospital from January 2019 to December 2020 were included in this study, and they were divided into mild group with 169 cases, moderate group with 92 cases and severe group with 39 cases according to the severity of chronic periodontitis. Pg test was performed on all subjects, and serum HMGB1, IL-1β and IL-6 levels and periodontal clinical indicators were detected. The differences of the above indicators were compared among the groups. Pearson correlation analysis was used to analyze the relationship between Pg concentration and serum HMGB1, IL-1β, IL-6 levels and periodontal clinical indicators in patients with chronic periodontitis. Results: The positive rate and concentration of PG infection in severe group and moderate group were higher than those in mild group, the above indexes in the severe group were higher than those in the moderate group(P＜0.05). The levels of serum HMGB1, IL-1β, IL-6 in severe group and moderate group were higher than those in mild group, the above indexes in the severe group were higher than those in the moderate group(P＜0.05). The levels of probing depth (PD), gingival creval bleeding index (SBI) and attachment loss (AL) in severe group and moderate group were higher than those in mild group, the above indexes in the severe group were higher than those in the moderate group(P＜0.05). Pearson correlation analysis showed that Pg infection in patients with chronic periodontitis was positively correlated with serum HMGB1, IL-1β, IL-6, PD, SBI and AL levels(P＜0.05). Conclusion: The concentration of PG in patients with chronic periodontitis is closely related to the levels of serum HMGB1, IL-1β, IL-6 and periodontal health. Early identification of Pg infection and detection of the above serological indicators may have guiding significance in inhibiting the progression of the disease and improving the therapeutic effect. |
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