| 夏 敏,寿宇雁,王 伟,曹 征,张之龄,吴 莘,潘 辉.灯银脑通胶囊联合丁苯酞软胶囊对急性脑梗死患者脑血流动力学和炎症因子的影响[J].现代生物医学进展英文版,2022,(5):847-851. |
| 灯银脑通胶囊联合丁苯酞软胶囊对急性脑梗死患者脑血流动力学和炎症因子的影响 |
| Effects of Dengyinnaotong Capsule Combined with Butylphthalide Soft Capsule on Cerebral Hemodynamics and Inflammatory Factors in Patients with Acute Cerebral Infarction |
| Received:September 23, 2021 Revised:October 18, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.05.010 |
| 中文关键词: 灯银脑通胶囊 丁苯酞软胶囊 急性脑梗死 脑血流动力学 炎症因子 |
| 英文关键词: Dengyinnaotong capsule Butylphthalide soft capsule Acute cerebral infarction Cerebral hemodynamics Inflammatory factor |
| 基金项目:上海市加强公共卫生体系建设三年行动计划项目（2020-2022）（GWV-5） |
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| 中文摘要: |
| 摘要 目的：观察灯银脑通胶囊联合丁苯酞软胶囊对急性脑梗死（ACI）患者脑血流动力学和炎症因子的影响。方法：选取我院于2019年4月~2021年3月期间收治的ACI患者120例，根据信封抽签法将患者分为对照组和联合组，例数均为60例。对照组给予丁苯酞软胶囊治疗，联合组给予灯银脑通胶囊联合丁苯酞软胶囊治疗，对比两组患者疗效、脑血流动力学、炎症因子、相关量表评分，记录两组治疗期间不良反应发生状况。结果：与对照组（51.67%）相比，联合组（71.67%）的临床总有效率进一步升高（P<0.05）。联合组治疗后改良Barthel指数评分高于对照组，美国国立卫生研究院卒中量表（NIHSS）评分低于对照组（P<0.05）。联合组治疗后收缩期峰值流速（Vs）、平均血流速度（Vm）高于对照组，搏动指数（PI）低于对照组（P<0.05）。联合组治疗后肿瘤坏死因子-α（TNF-α）、血清超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）水平低于对照组（P<0.05）。两组不良反应发生率组间对比无差异（P>0.05）。结论：ACI患者在丁苯酞软胶囊治疗基础上结合灯银脑通胶囊治疗，可明显减轻神经功能损害，改善脑血流动力学，同时还可降低机体内炎症因子水平，促进生活自理能力提高。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of dengyinnaotong capsule combined with butylphthalide soft capsule on cerebral hemodynamics and inflammatory factors in patients with acute cerebral infarction(ACI). Methods: 120 patients with ACI who were treated in our hospital from April 2019 to March 2021 were selected. According to the envelope lottery method, the patients were divided into control group and combined group, with 60 cases. The control group was treated with butylphthalide soft capsule, and the combined group was treated with butylphthalide soft capsule and dengyinnaotong capsule. The curative effect, cerebral hemodynamics, inflammatory factors and related scale scores of the two groups were compared, and the occurrence of adverse reactions during the treatment of the two groups were recorded. Results: Compared with the control group(51.67%), the total clinical effective rate of the combined group (71.67%) was further increased(P<0.05). After treatment, the modified Barthel index score of the combined group was higher than that of the control group, and the National Institutes of Health Stroke Scale score (NIHSS) was lower than that of the control group (P<0.05). The peak systolic velocity (Vs) and mean blood flow velocity (Vm) of the combined group after treatment were higher than those of the control group, and the pulsatile index (PI) was lower than that of the control group (P<0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α), serum hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) of combined group were lower than those of control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The treatment of patients with ACI on the basis of butylphthalide soft capsule combined with dengyinnaotong capsule can significantly reduce neurological impairment, improve cerebral hemodynamics, reduce the level of inflammatory factors in the body, and promote the improvement of self-care ability. |
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