| 赵姝娟,张光华,周晓光,姜思旭,于婷婷.上皮性卵巢癌患者CT、MRI影像学特征及与血清标志物CEA、CA199、CA125水平的相关性研究[J].现代生物医学进展英文版,2022,(4):775-780. |
| 上皮性卵巢癌患者CT、MRI影像学特征及与血清标志物CEA、CA199、CA125水平的相关性研究 |
| Correlation between CT, MRI Imaging Features and Serum Markers CEA, CA199, CA125 in Patients with Epithelial Ovarian Cancer |
| Received:June 05, 2021 Revised:June 27, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.04.037 |
| 中文关键词: 上皮性卵巢癌 影像学特征 CEA CA199 CA125 相关性 |
| 英文关键词: Epithelial ovarian cancer Imaging features CEA CA199 CA125 Correlation |
| 基金项目:辽宁省科学技术局项目（2001J-2-50-05）；国家自然科学基金项目（81172197） |
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| 中文摘要: |
| 摘要 目的：探讨上皮性卵巢癌患者电子计算机断层扫描（CT）、磁共振成像（MRI）影像学特征及与血清标志物癌胚抗原（CEA）、糖类抗原199（CA199）、糖类抗原125（CA125）水平的相关性。方法：回顾性分析2014年4月-2020年2月于我院83例诊断为上皮性卵巢癌患者的CT、MRI影像学资料，以手术病理结果作为金标准。分析患者的CT、MRI影像学特征，检测患者血清CEA、CA199、CA125水平，评价患者CT、MRI影像学特征与血清CEA、CA199、CA125水平的相关性。结果：上皮性卵巢癌肿瘤横截面最大径为14.2mm-121.7mm，平均（18.6±4.3）mm，上皮性卵巢癌以混杂密度/信号为主，形态不规则，病灶多为囊实性，可见壁结节及分隔改变，增强后可见分隔或壁结节明显强化，可伴有腹水、腹膜转移、淋巴结转移。血清CEA、CA199、CA125水平分别为（66.35±7.52）ng/mL、（183.59±22.62）U/mL、（225.27±25.34）U/mL。上皮性卵巢癌边界清晰、不清晰的血清CA199、CA125水平组间差异有统计学意义（P＜0.05）；上皮性卵巢癌形态圆形/类圆形/椭圆形、分叶状、形态不规则的血清CA199、CA125水平组间差异有统计学意义（P＜0.05）；上皮性卵巢癌患者有壁结节、腹膜转移、淋巴结转移的血清CEA、CA199、CA125水平组间差异有统计学意义（P＜0.05）；其余CT、MRI影像学表现特征组间血清CEA、CA199、CA125水平差异无统计学意义（P＞0.05）。上皮性卵巢癌边界与血清CA125水平呈正相关（P＜0.05），上皮性卵巢癌形态与血清CA199、CA125水平呈正相关（P＜0.05），壁结节与血清CA125水平呈正相关（P＜0.05），腹膜转移、淋巴结转移与血清CEA、CA199、CA125水平呈正相关（P＜0.05），其余指标之间无明显相关性（P＞0.05）。结论：上皮性卵巢癌CT、MRI影像表现具有特征性，血清CEA、CA199、CA125水平的检测有助于对早期上皮性卵巢癌的诊断以及不同病理类型的判断，CT、MRI影像学特征与血清CEA、CA199、CA125水平具有相关性，可判断疾病的进展及患者预后情况，对指导临床综合治疗及评估患者预后可提供客观依据。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between Computed Tomography(CT), Magnetic Resonance Imaging(MRI) imaging features and the levels of carcinoembryonic antigen(CEA), Carbohydrate antigen199(CA199) and Carbohydrate antigen125(CA125) in patients with epithelial ovarian cancer. Methods: The CT and MRI imaging data of 83 patients with epithelial ovarian cancer diagnosed in our hospital from April 2014 to February 2020 were retrospectively analyzed. The CT and MRI imaging features of the patients were analyzed, the serum levels of CEA, CA199 and CA125 were detected, and the correlation between CT and MRI imaging features and serum levels of CEA, CA199 and CA125 was evaluated. Results: The maximum cross-sectional diameter of epithelial ovarian cancer was 14.2mm-121.7mm, with an average of (18.6±4.3) mm, epithelial ovarian cancer is mainly mixed density/signal, irregular shape, lesions were mostly cystic and solid, wall nodules and septal changes can be seen, septal or wall nodules can be seen after enhancement, ascites, peritoneal metastasis, lymph node metastasis can be accompanied. The serum levels of CEA, CA199 and CA125 were(66.351±7.52)ng/mL, (183.59±22.62)U/mL, (225.27±25.34)U/mL. There were statistically significant differences in the serum CA199 and CA125 levels of epithelial ovarian cancer with clear boundaries and unclear boundaries (P<0.05). There were significant differences in the serum CA199 and CA125 levels of epithelial ovarian cancer in round/para-round/oval, lobulated and irregular shapes (P<0.05). There were statistically significant differences in serum CEA, CA199 and CA125 levels in epithelial ovarian cancer patients with mural nodules, peritoneal metastasis and lymph node metastasis (P<0.05), while other CT and MRI imaging features showed no significant difference in serum CEA, CA199 and CA125 levels between the groups (P>0.05). The boundary of epithelial ovarian cancer was positively correlated with serum CA125 level (P<0.05), the morphology of epithelial ovarian cancer was positively correlated with serum CA199 and CA125 level (P<0.05), and the wall nodules were positively correlated with serum CA125 level (P<0.05). Peritoneal metastasis and lymph node metastasis were positively correlated with serum levels of CEA, CA199 and CA125 (P<0.05), while there was no significant correlation between other indexes (P>0.05). Conclusion: CT and MRI imaging features of epithelial ovarian cancer are characteristic. The detection of serum CEA, CA199 and CA125 levels is helpful for the diagnosis of early epithelial ovarian cancer and the judgment of different pathological types. CT and MRI imaging features are correlated with serum CEA, CA199 and CA125 levels. It can judge the progress of the disease and the prognosis of the patients, and provide objective basis for guiding clinical comprehensive treatment and evaluating the prognosis of the patients. |
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