| 刘 慧,梁 婧,谷学兰,陶 洪,武琳琳,龙海灯.2型糖尿病合并高血压患者血清同型半胱氨酸水平与肾功能和颈动脉粥样硬化的相关性分析[J].现代生物医学进展英文版,2022,(4):766-769. |
| 2型糖尿病合并高血压患者血清同型半胱氨酸水平与肾功能和颈动脉粥样硬化的相关性分析 |
| Correlation Analysis between Serum Homocysteine Level and Renal Function and Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus Complicated with Hypertension |
| Received:September 05, 2021 Revised:September 27, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.04.035 |
| 中文关键词: 2型糖尿病 高血压 同型半胱氨酸 肾功能 颈动脉粥样硬化 |
| 英文关键词: Type 2 diabetes mellitus Hypertension Homocysteine Renal function Carotid atherosclerosis |
| 基金项目:安徽省卫生厅第二批科研计划项目（13FR027） |
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| 中文摘要: |
| 摘要 目的：探讨2型糖尿病（T2DM）合并高血压患者血清同型半胱氨酸（Hcy）水平与肾功能和颈动脉粥样硬化的关系。方法：回顾性分析2018年7月~2021年5月安徽省第二人民医院收治的168例T2DM患者的临床资料，按照是否合并高血压分为T2DM合并高血压组（合并组）87例和单纯T2DM组（T2DM组）81例，另选取同期健康体检者87例为对照组，比较各组血清Hcy水平、肾功能指标[血清肌酐（Scr）、尿液肌酐（CR）、尿微量白蛋白/肌酐(ACR)、尿免疫球蛋白G/肌酐(IGU/CR)、尿转铁蛋白/肌酐(TRU/CR)、尿α1-微量球蛋白/肌酐(α1/CR)、肾小球滤过率（eGFR）]及左侧、右侧颈动脉内膜中层厚度（IMT）、Crouse积分，Pearson相关性分析Hcy水平与肾功能指标、IMT、Crouse积分的相关性。结果：合并组、T2DM组血清Hcy、Scr、CR、ACR、IGU/CR、TRU/CR、α1/CR水平及左侧IMT、右侧IMT、Crouse积分高于对照组，且合并组以上指标高于T2DM组（P＜0.05）；合并组、T2DM组eGFR水平低于对照组，且合并组低于T2DM组（P＜0.05）；Pearson相关性分析结果显示：T2DM合并高血压患者血清Hcy水平与Scr、CR、ACR、IGU/CR、TRU/CR、α1/CR水平及左侧IMT、右侧IMT、Crouse积分呈正相关（P＜0.05），与eGFR水平呈负相关（P＜0.05）。结论：T2DM合并高血压患者血清Hcy水平异常升高，其与患者肾功能损伤及颈动脉粥样硬化有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum homocysteine (Hcy) level and renal function and carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) complicated with hypertension. Methods: The clinical data of 168 patients with T2DM who were admitted to Anhui Second People's Hospital from July 2018 to May 2021 were retrospectively analyzed. According to whether they were complicated with hypertension or not, they were divided into T2DM complicated with hypertension group (combined group) 87 cases and simple T2DM group (T2DM group) 81 cases, another 87 healthy subjects were selected as the control group during the same period. The serum Hcy level and renal function indexes [serum creatinine(Scr), urine creatinine(CR), urine microalbumin/creatinine(ACR), urine immunoglobulin G/creatinine (IGU/CR), urine transferrin/creatinine (TRU/CR), urine α1-microglobulin/creatinine(α1/CR), Glomerular filtration rate (eGFR)] and left and right carotid intima-media thickness (IMT), Crouse integral of each group were compared. The correlation between Hcy level and renal function indexes, IMT, Crouse integral were analyzed by Pearson correlation analysis. Results: The level of the serum Hcy, Scr, CR, ACR, IGU/CR, TRU/CR, α1/CR and left IMT, right IMT, Crouse integral in the combined group and T2DM group were higher than those in the control group, and those in the combined group were higher than those in T2DM group (P<0.05). The level of eGFR in the combined group and T2DM group was lower than that in the control group, and that in the combined group was lower than that in the T2DM group (P<0.05). Pearson correlation analysis showed that the serum Hcy level was positively correlated with Scr, CR, ACR, IGU/CR, TRU/CR, α1/CR, left IMT, right IMT and Crouse integral in T2DM patients with hypertension (P<0.05), and negatively correlated with eGFR level (P<0.05). Conclusion: The serum Hcy level in T2DM patients with hypertension is abnormally increased, which is related to renal function injury and carotid atherosclerosis. |
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