| 田 玉,杨玉淑,丁 萌,张明峰,彭晨星,刘爱京,高丽霞.系统性红斑狼疮患者血清β2-MG、PGRN、Gas6水平与疾病严重程度和肾脏损害的关系研究[J].现代生物医学进展英文版,2022,(4):752-756. |
| 系统性红斑狼疮患者血清β2-MG、PGRN、Gas6水平与疾病严重程度和肾脏损害的关系研究 |
| Study on the Relationship between the Levels of β2-MG, PGRN and Gas6 and Disease Severity and Renal Damage in Patients with Systemic Lupus Erythematosus |
| Received:May 23, 2021 Revised:June 18, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.04.032 |
| 中文关键词: 系统性红斑狼疮 β2-MG PGRN Gas6 疾病严重程度 肾脏损害 |
| 英文关键词: Systemic lupus erythematosus β2-MG PGRN Gas6 Disease severity Kidney damage |
| 基金项目:国家自然科学基金面上项目（81970600） |
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| 中文摘要: |
| 摘要 目的：探讨系统性红斑狼疮患者血清β2-微球蛋白（β2-MG）、颗粒蛋白前体（PGRN）、生长停滞基因6（Gas6）水平与疾病严重程度和肾脏损害的关系。方法：选择2017年1月至2020年12月河北医科大学第二医院风湿免疫科收治的系统性红斑狼疮患者105例，根据系统性红斑狼疮疾病活动度指数(SLEDAI)将患者分为活动期组(SLEDAI≥5分)62例，缓解期组(SLEDAI ≤4分)43例。另取同期于河北医科大学第二医院接受体检的健康志愿者60例作为对照组。比较各组血清β2-MG、PGRN、Gas6、红细胞沉降率（ESR）、C反应蛋白（CRP）、血清补体、抗dsDNA抗体、血尿素氮（BUN）、血肌酐（Scr），24 h尿蛋白（24h UTP），并分析其相关性。结果：活动期组β2-MG、PGRN、ESR、CRP、抗dsDNA抗体、BUN、Scr、24 h UTP水平高于缓解期组、对照组，Gas6、血清补体C3、C4水平低于缓解期组、对照组；缓解期组β2-MG、PGRN、ESR、CRP、抗dsDNA抗体、BUN、Scr、24 h UTP水平均高于对照组，Gas6、血清补体C3、C4水平低于对照组，活动期组SLEDAI评分高于缓解期组（P＜0.05）。 Pearson相关性分析可得：系统性红斑狼疮患者血清β2-MG、PGRN与SLEDAI 、ESR、CRP、抗dsDNA、BUN、Scr、24h UTP呈正相关，与血清补体C3、补体C4呈负相关（均P＜0.05），Gas6水平与SLEDAI、ESR、CRP、抗dsDNA、BUN、Scr、24h UTP呈负相关，与血清补体C3、补体C4呈正相关（均P＜0.05）。结论：系统性红斑狼疮患者血清β2-MG、PGRN水平异常升高，Gas6水平异常降低，且和患者疾病活动程度及肾脏损害密切相关，检测其水平可能为系统性红斑狼疮疾病的评估提供参考。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the study on the relationship between the levels of β2-microglobulin (β2-MG), Granule protein precursor (PGRN) and Growth arrest gene 6 (Gas6) and disease severity and renal damage in patients with systemic lupus erythematosus. Methods: 105 patients with systemic lupus erythematosus who were treated in the rheumatology and immunology department of the second hospital of Hebei medical university from January 2017 to December 2020 were selected. According to the systemic lupus erythematosus disease activity index (SLEDAI), the patients were divided into 62 cases in the active phase group (SLEDAI ≥5 points) and 43 cases in the remission phase group (SLEDAI ≤ 4 points). Another 60 healthy volunteers who underwent physical examination in the second hospital of Hebei medical university in the same period were taken as the control group. Serum β2-MG, PGRN, Gas6, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum complement, anti dsDNA antibody, blood urea nitrogen (BUN), blood creatinine (Scr), 24 h urinary protein (24 h UTP) were compared between the two groups, and analyze its correlation. Results: β2-MG, PGRN, ESR, CRP, anti dsDNA antibody, BUN, Scr, 24 h UTP in the active phase group were higher than those of the remission phase group and control group. Gas6, serum complement C3, C4 were lower than those of the remission phase group and control group. β2-MG, PGRN, ESR, CRP, anti dsDNA antibody, BUN, Scr, 24 h UTP in the remission phase group were higher than those of the control group. Gas6, serum complement C3, C4 were lower than those of the control group. The SLEDAI score in the active group was higher than that in the remission group（P＜0.05）. Pearson correlation analysis showed that: Serum of patients with systemic lupus erythematosus β2-MG and PGRN were positively correlated with SLEDAI, ESR, CRP, anti dsDNA, bun, SCR and 24 h UTP, and negatively correlated with serum complement C3 and C4 (all P<0.05). Gas6 level was negatively correlated with SLEDAI, ESR, CRP, anti dsDNA, bun, SCR and 24 h UTP, and positively correlated with serum complement C3 and C4 (all P<0.05). Conclusion: Serum of patients with systemic lupus erythematosus β The levels of 2-mg and PGRN increased abnormally and the level of Gas6 decreased abnormally, which is closely related to the degree of disease activity and renal damage. The detection of their levels may provide a reference for the evaluation of systemic lupus erythematosus disease. |
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