| 刘玉林,孙彩虹,刁甜甜,宋鹏龙,姜 娜,张贵新,胡 琪.孤独症谱系障碍儿童听觉脑干反应特征分析[J].现代生物医学进展英文版,2022,(4):702-706. |
| 孤独症谱系障碍儿童听觉脑干反应特征分析 |
| Characteristics and Clinical Phenotypes of Auditory Brainstem Response in Children with Autism Spectrum Disorders |
| Received:May 07, 2021 Revised:May 30, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.04.022 |
| 中文关键词: 孤独症 听觉脑干反应 儿童 |
| 英文关键词: Autism spectrum disorders Auditory brainstem response Child |
| 基金项目:黑龙江省省属高等学校基本科研业务费科研项目(2019-KYYWF-0333) |
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| 中文摘要: |
| 摘要 目的：探讨孤独症谱系障碍(autism spectrum disorder，ASD)儿童听觉脑干反应(auditory brainstem response,ABR)各波潜伏期和波间期特征与ASD行为表型间的关联。方法：对2019年7月-2020年12月来我科就诊的26例明确诊断的2~6岁ASD儿童的患儿进行声导抗，听性脑干反应，畸变产物耳声发射及多频稳态听觉诱发电位测试，以38例正常儿童为对照组，进行同样的测试,并对其测试结果进行统计分析。分析ASD儿童左右耳各波潜伏期，波间期特征及与ASD临床表型的关联。结果：ASD儿童左右耳Ⅰ，Ⅲ，Ⅴ波潜伏期分别为(1.42±0.09)ms，(3.67±0.09)ms，(5.65±0.13)ms；(1.45±0.11)ms，(3.69±0.08)ms，(5.62±0.15)ms。ASD组的右耳I，III波的潜伏期均值大于正常组 (P 值均＜0.05)；ASD儿童两组间左耳III-V,右耳III-V，右耳I-V的波间期分别是(1.97±0.07)ms，(1.93±0.10)ms，(4.15±0.14)ms；ASD组的左耳III-V，右耳III-V，右耳I-V波间期均小于正常组(P 值均＜0.05)；ASD组中小于等于3岁组与大于3岁组间ABR波间期差异不具有统计学意义。关联性分析发现，ASD儿童语言能力与右耳III波潜伏期，右耳最小阈值V波潜伏期负相关；社会行为能力与右耳I-III波间期负相关；社会生活能力与左耳最小阈值V波潜伏期负相关；而ABC评分与ASD儿童右耳III波潜伏期,左耳I-III波间期，右耳I-III波间期正相关。结论：ASD儿童存在异常的听觉脑干反应特征，且异常程度与 ASD 儿童语言，社会行为能力,社会生活能力的严重程度存在明显关联。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the characteristics of Auditory brainstem response (ABR) in children with autism spectrum disorders(ASD), and analyze their associations with the core symptoms of ASD. Methods: A total of thirty-eight children with normal hearing and twenty-six autistic children were enrolled in this study. The data of acoustic immitance, auditory brainstem response, and distortion product otoacoustic emissions (DPOAEs) were collected. The association among the characteristics of latent period and interlatent period of each wave, core symptoms of ASD children behavior and clinical manifestation was analyzed. Results: ASD children left and right ear Ⅰ Ⅲ, Ⅴ wave latent period respectively, (1.42±0.09) ms, (3.67±0.09) ms, (5.65±0.13) ms; (1.45± 0.11)ms, (3.69 ± 0.08)ms, (5.62±0.15)ms. The mean latent period of right ear I and right ear III in ASD group were longer than those in normal group (P<0.05). The left ear III-V, right ear III-V and right ear I-V interlatent period respectively (1.97±0.07)ms, (1.93± 0.10)ms, (4.15± 0.14)ms. The left ear III-V, right ear III-V and right ear I-V interlatent period of ASD group were all shorter than those of normal group(P＜0.05). In the ASD group, test was used to analyze the ABR peak interval differences between the groups 3 years or less and older than 3 years, and the peak interval differences of both ears between the two groups were not statistically significant. The correlation analysis showed that the language ability of ASD children was negatively correlated with the right ear III latent period and the minimum threshold V-wave latent period in the right ear. Social behavior ability was negatively correlated with right ear I-III interlatent period. The social life ability was negatively correlated with the minimum threshold V-wave latent period of the left ear. ABC score was positively correlated with right ear III latent period, left ear I-III and right ear I-III interlatent period. Conclusion: There are abnormal auditory behavior characteristics in ASD children, and the degree of abnormality is significantly correlated with the severity of language development, social behavior ability and social ladaptation ability in ASD children. |
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