| 何慧梅,阮兆娟,李丽凤,鞠海兵,余雪婷.不同肠内营养支持方案对2型糖尿病并发急性脑卒中患者肠黏膜屏障功能和Th17/Treg免疫应答平衡的影响[J].现代生物医学进展英文版,2022,(4):698-701. |
| 不同肠内营养支持方案对2型糖尿病并发急性脑卒中患者肠黏膜屏障功能和Th17/Treg免疫应答平衡的影响 |
| Effects of Different Enteral Nutrition Support Schemes on Intestinal Mucosal Barrier Function and Th17/Treg Immune Response Balance in Patients with Type 2 Diabetes Mellitus Complicated with Acute Stroke |
| Received:June 05, 2021 Revised:June 30, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.04.021 |
| 中文关键词: 肠内营养 2型糖尿病 急性脑卒中 肠黏膜屏障功能 Th17/Treg免疫应答 |
| 英文关键词: Enteral nutrition Type 2 diabetes mellitus Acute stroke Intestinal mucosal barrier function Th17/Treg immune response |
| 基金项目:云南省应用基础研究计划项目（2011FB158） |
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| 中文摘要: |
| 摘要 目的：对比不同肠内营养支持方案对2型糖尿病（T2DM）并发急性脑卒中患者肠黏膜屏障功能和Th17/Treg免疫应答平衡的影响。方法：选取我院2019年3月~2021年2月期间收治的93例T2DM并发急性脑卒中患者，按照信封抽签法将患者分为对照组（46例）和研究组（47例），对照组接受传统肠内营养支持方案，研究组接受个体化肠内营养支持方案，观察两组血糖水平、营养指标、肠黏膜屏障功能和Th17/Treg免疫应答平衡变化。结果：研究组治疗 1~7 d 后的血糖水平均低于对照组（P<0.05）。治疗7 d后，研究组血清前白蛋白、白蛋白、血红蛋白水平高于对照组（P<0.05）。治疗7 d后，研究组血浆内毒素（ET）、二胺氧化酶（DAO）低于对照组（P<0.05）。治疗7 d后，研究组Th17、Th17/Treg低于对照组；Treg高于对照组（P<0.05）。结论：个体化肠内营养支持方案有利于降低T2DM并发急性脑卒中患者的血糖水平，促进肠粘膜屏障功能的恢复，进而改善机体营养状态及免疫状态。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the effects of different enteral nutrition support schemes on intestinal mucosal barrier function and Th17/Treg immune response balance in patients with type 2 diabetes mellitus (T2DM) complicated with acute stroke. Methods: 93 patients with T2DM complicated with acute stroke in our hospital from March 2019 to February 2021 were selected, and they were divided into the control group (46 cases) and the study group (47 cases) according to the envelope drawing method. The control group received the traditional enteral nutrition support scheme, and the study group received the individualized enteral nutrition support scheme. The blood glucose level, nutritional indexes, intestinal mucosal barrier function and Th17/Treg immune response balance were observed in two groups. Results: The blood glucose level of the observation group was lower than that of the control group at 1~7 d after treatment (P<0.05). 7 d after treatment, the serum albumin, prealbumin and hemoglobin levels of the study group were higher than those of the control group (P<0.05). 7 d after treatment, the plasma endotoxin (ET) and diamine oxidase (DAO) of the study group were lower than those of the control group (P<0.05). 7 d after treatment, Th17 and Th17/Treg of the study group were lower than those of the control group. Treg was higher than that of control group (P<0.05). Conclusion: Individualized enteral nutrition support scheme is beneficial to reduce the blood glucose level of patients with T2DM complicated with acute stroke, promote the recovery of intestinal mucosal barrier function, and then improve the nutritional status and immune status of the body. |
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