| 张 晶,孙以琳,周轶蓉,赵 萍,黄静文,王晓敏.老年稳定期精神分裂症患者睡眠障碍现状调查及对记忆功能的影响[J].现代生物医学进展英文版,2022,(4):684-687. |
| 老年稳定期精神分裂症患者睡眠障碍现状调查及对记忆功能的影响 |
| Status Investigation of Sleep Disorder in Elderly Patients with Stable Schizophrenia and Its Effect on Memory Function |
| Received:July 06, 2021 Revised:July 30, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.04.018 |
| 中文关键词: 老年 稳定期精神分裂症 睡眠障碍 记忆功能 影响因素 |
| 英文关键词: Elderly Stable schizophrenia Sleep disorders Memory function Influencing factors |
| 基金项目:上海市精神卫生中心科研计划项目（2019YJH03）；上海市卫生健康委科研项目(201640208) |
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| 中文摘要: |
| 摘要 目的：调查老年稳定期精神分裂症患者睡眠障碍现状，分析其影响因素，并分析老年稳定期精神分裂症患者睡眠障碍与记忆功能的关系。方法：选择2018年5月~2021年5月期间我院收治的100例老年稳定期精神分裂症患者。采用自制临床资料调查问卷采集患者临床资料，采用匹茨堡睡眠质量指数（PSQI）评价所有患者的睡眠状况，采用多维记忆评估量表（MMAS）评价所有患者的记忆功能，单因素及多因素Logistic回归分析老年稳定期精神分裂症患者睡眠障碍的影响因素。Pearson检验分析PSQI评分与记忆功能评分的相关性。结果：纳入的100例老年稳定期精神分裂症患者中，有68例发生睡眠障碍，睡眠障碍发生率为68.00%。根据患者有无睡眠障碍分为两组：睡眠障碍组（n=68）和无睡眠障碍组（n=32）。单因素分析结果显示：老年稳定期精神分裂症患者睡眠障碍与年龄、性别、户籍所在地、文化水平、婚姻状况、发病情况、收入情况有关（P<0.05），而与精神症状无关（P>0.05）。多因素Logistic回归分析显示婚姻状况为未婚/离异/丧偶、户籍所在地为城镇、性别男、年龄>70岁、文化水平为中学、收入情况为无是老年稳定期精神分裂症患者睡眠障碍的危险因素（P＜0.05）。睡眠障碍组汉词记忆、汉词配对、图画记忆评分低于无睡眠障碍组，PSQI评分高于无睡眠障碍组（P<0.05）。老年稳定期精神分裂症伴睡眠障碍患者PSQI评分与汉词配对、图画记忆、汉词记忆评分呈负相关（P＜0.05）。结论：老年稳定期精神分裂症患者存在较高的睡眠障碍发生率，且受到年龄、性别、户籍所在地等多种因素的影响。睡眠障碍可影响患者记忆功能状况，睡眠障碍越严重，记忆功能越差。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the status of sleep disorders in elderly patients with stable schizophrenia, analyze its influencing factors, and analyze the relationship between sleep disorder and memory function in elderly patients with stable schizophrenia. Methods: 100 elderly patients with stable schizophrenia who were treated in our hospital from May 2018 to May 2021 were selected. The clinical data of patients were collected by self-made clinical data questionnaire, the sleep status of all patients was evaluated by Pittsburgh sleep quality index (PSQI), and the memory function of all patients was evaluated by multidimensional memory assessment scale (MMAS). Univariate and multivariate Logistic regression analysis of influencing factors of sleep disturbance in elderly patients with stable schizophrenia. Pearson test was used to analyze the correlation between PSQI score and memory function score. Results: Among the 100 elderly patients with stable schizophrenia, 68 had sleep disorders, and the incidence of sleep disorders was 68.00%. Patients were divided into two groups according to whether they had sleep disorder: sleep disorder group (n=68) and no sleep disorder group (n=32). Univariate analysis showed that sleep disorders in patients with elderly stable schizophrenia were related to age, gender, household registration, education level, marital status, morbidity and income (P<0.05), but not to mental symptoms (P>0.05). Multivariate Logistic regression analysis showed that marital status unmarried/divorced/widowed, household registration in urban areas, gender male, age >70 years, education level of middle school, income of no age were risk factors for sleep disorder in elderly patients with stable schizophrenia (P<0.05). The scores of Chinese word memory, Chinese word pairing and picture memory in the sleep disorder group were lower than those in the group without sleep disorder, and the PSQI scores were higher than those in the no sleep disorder group (P<0.05). PSQI score was negatively correlated with Chinese word pairing, picture memory and Chinese word memory score in elderly patients with stable schizophrenia and sleep disorder (P<0.05). Conclusion: Elderly patients with stable schizophrenia have a higher incidence of sleep disorder, and it is affected by many factors such as age, gender, household registration and so on. Sleep disorder can affect the memory function of patients, the more serious the sleep disorder, the worse the memory function. |
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