| 季莹莹,侯慧艳,姜 静,陈华林,黄佳佳.托烷司琼与帕洛诺司琼用于小儿骨科术后镇痛预防恶心呕吐的效果研究[J].现代生物医学进展英文版,2022,(4):665-668. |
| 托烷司琼与帕洛诺司琼用于小儿骨科术后镇痛预防恶心呕吐的效果研究 |
| Effect of Tropisetron and Palonosetron on Postoperative Analgesia and Prevention of Nausea and Vomiting in Children |
| Received:July 06, 2021 Revised:July 30, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.04.014 |
| 中文关键词: 托烷司琼 帕洛诺司琼 儿童 骨科 术后恶心呕吐 |
| 英文关键词: Tropisetron Palonosetron Children Orthopedics Postoperative nausea and vomiting |
| 基金项目:上海市科技计划项目（20DZ2306700） |
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| 中文摘要: |
| 摘要 目的：比较托烷司琼与帕洛诺司琼用于小儿骨科术后镇痛时预防恶心呕吐的效果。方法：纳入2019年3月到2021年3月在我院进行骨科手术的儿童60例，根据术后镇痛泵中使用止吐药物的不同分为托烷司琼组和帕洛诺司琼组，每组30例，比较两组患儿术前、术后的心率（HR）、平均动脉压（MAP），在术后48小时内，观察两组患儿恶心呕吐、头晕头痛、皮肤瘙痒以及呼吸抑制等术后并发症。视觉模拟评分法（VAS）评估患儿术后疼痛，Ramsay量表评估患儿术后镇静效果。结果：托烷司琼和帕洛诺司琼组患儿在术前和术后HR和MAP比较均无显著差异（P>0.05）；托烷司琼组和帕洛诺司琼组患儿术后VAS评分、Ramsay评分均随时间延长而降低，且同一时间点两组患儿VAS评分无显著差异（P>0.05）；帕洛诺司琼组术后PONV发生率（20.00 %）高于托烷司琼组（3.33 %）（P<0.05）。帕洛诺司琼组和托烷司琼组患儿出现头晕头痛、皮肤瘙痒以及呼吸抑制例数分别为3/2例、1/0例和1/0例。两组间术后并发症发生率比较无差异（P>0.05）。结论：托烷司琼与帕洛诺司琼对骨科手术后儿童血流动力学、疼痛和镇静效果并无差异，但在预防术后恶心呕吐方面托烷司琼效果优于帕洛诺司琼。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the effects of tropisetron and palonosetron on prevention of nausea and vomiting in pediatric orthopedic postoperative analgesia. Methods: A total of 60 children undergoing orthopedic surgery in our hospital from March 2019 to March 2021 were included. According to the different antiemetic drugs used in postoperative analgesia pump, they were divided into tropisetron group and palonosetron group, with 30 patients in each group. The preoperative and postoperative heart rate (HR) and mean arterial pressure (MAP) of the two groups were compared. Postoperative complications such as nausea, vomiting, dizziness, headache, skin itching and respiratory depression were observed in the two groups. Results: There was no significant difference in preoperative and postoperative HR and MAP between tropisetron and palonosetron (P>0.05). Postoperative VAS scores and Ramsay scores in tropisetron group and palonosetron group decreased with time, and there was no significant difference in VAS scores between the two groups at the same time point (P>0.05). The incidence of PONV in palonosetron group (20.00 %) was higher than that in tropisetron group (3.33 %) (P>0.05). The cases of drowsiness, itchy skin and dyspnea were 3 cases, 0 cases and 1 case in palonosetron group, respectively, while there were 2 cases, 0 cases and 0case in tropansetron group, but there was no difference in postoperative complications between the two groups (P>0.05). Conclusion: Tropisetron and Palonosetron have no difference in hemodynamics, pain and sedation in children after orthopedic surgery, but tropisetron is better than palonosetron in preventing postoperative malignant vomiting . |
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