| 周瑞娟,余 波,阚世锋,何 霏,孙 然,柴 松,陈文华,张见平.心肺康复训练对脑卒中患者的康复效果及对血清BDNF、NT-3、MMP-9及心肺功能的影响[J].现代生物医学进展英文版,2022,(4):655-659. |
| 心肺康复训练对脑卒中患者的康复效果及对血清BDNF、NT-3、MMP-9及心肺功能的影响 |
| Effect of Cardiopulmonary Rehabilitation Training on Cerebral Apoplexy Patients and Its Effect on Serum BDNF, NT-3, MMP-9 and Cardiopulmonary Function |
| Received:June 07, 2021 Revised:June 30, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.04.012 |
| 中文关键词: 心肺康复训练 脑卒中 康复效果 脑源性神经生长因子 神经营养因子-3 基质金属蛋白酶-9 心肺功能 |
| 英文关键词: Cardiopulmonary rehabilitation training Stroke Rehabilitation effect Brain-derived nerve growth factor Neurotrophic factor-3 Matrix metalloproteinase-9 Cardiopulmonary function |
| 基金项目:上海市体育科技"综合计划"项目（19Z009） |
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| 中文摘要: |
| 摘要 目的：探讨心肺康复训练对脑卒中患者的康复效果及对血清脑源性神经生长因子（BDNF）、神经营养因子-3（NT-3）、基质金属蛋白酶-9（MMP-9）及心肺功能的影响。方法：选择2020年01月-2021年01月在我院接受治疗的129例脑卒中患者，采用抽签法分为试验组（n=65）和对照组（n=64）。对照组给予常规康复治疗，试验组给予心肺康复训练治疗。比较两组患者的临床疗效、血清BDNF、NT-3、MMP-9、左心室射血分数（LVEF）、左心室收缩末期内径（LVESD）、最大心率、静息心率、峰值摄氧量（VO2peak ）、无氧阈（AT）、峰值能量代谢当量（MET peak）、每分峰值通气量（VE peak ）及Fugl-Meyer评定量表（FMA）、改良Barthel指数（MBI）评分变化情况。结果：治疗后，两组总有效率比较差异显著（P<0.05）；治疗前，试验组和对照组血清BDNF、NT-3、MMP-9比较无显著差异；治疗后，试验组和对照组血清BDNF随着时间的推移而升高，且试验组均高于对照组，NT-3、MMP-9随着时间的推移而降低，且试验组均低于对照组，差异显著（P<0.05）；治疗前，试验组和对照组LVEF、LVESD、最大心率及静息心率比较无显著差异；治疗后，试验组和对照组LVEF、最大心率随着时间的推移而升高，且试验组均高于对照组，LVESD、静息心率随着时间的推移而降低，且试验组均低于对照组，差异显著（P<0.05）；治疗前，试验组和对照组VO2peak 、AT、MET peak及VE peak 比较无显著差异；治疗后，试验组和对照组VO2peak 、AT、MET peak 及VE peak 随着时间的推移而升高，且试验组均高于对照组，差异显著（P<0.05）；治疗前，试验组和对照组FMA、MBI评分比较无显著差异；治疗后，试验组和对照组FMA、MBI评分随着时间的推移而升高，且试验组均高于对照组，差异显著（P<0.05）。结论：在脑卒中患者中应用心肺康复训练临床效果更好，可有改善患者血清BDNF、NT-3、MMP-9及心肺功能。 |
| 英文摘要: |
| ABSTRACT Objective: Effect of cardiopulmonary rehabilitation training on cerebral apoplexy patients and its effect on serum Brain-derived nerve growth factor (BDNF), neurotrophic factor-3 (NT-3), matrix metalloproteinase-9 (MMP-9) and cardiopulmonary function. Methods: 129 stroke patients treated in our hospital from January 2020 to January 2021 were selected and divided into experimental group (n=65) and control group (n=64) by drawing lots. The control group was given routine rehabilitation treatment, and the experimental group was given cardiopulmonary rehabilitation training treatment. Clinical efficacy, serum BDNF, NT-3, MMP-9, left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), maximum heart rate, resting heart rate, peak oxygen uptake (VO2Peak ), anaerobic threshold (AT), peak energy metabolic equivalent (MET) were compared between 2 groups Peak), Ve Peak , Fugl-Meyer Rating Scale (FMA) and Modified Barthel Index (MBI) scores. Results: After treatment, the total effective rate between the two groups was significantly different (P<0.05). Before treatment, there were no significant differences in serum BDNF, NT-3 and MMP-9 between the experimental group and the control group. After treatment, serum BDNF in experimental groups and control group increased with time, and NT-3 and MMP-9 decreased with time, and the difference was significant (P<0.05). Before treatment, there were no significant differences in LVEF, LVESD, maximum heart rate and resting heart rate between the experimental group and the control group. After treatment, LVEF and maximum heart rate in experimental and control groups increased over time, and those in experimental groups were higher than those in control group, while LVESD and resting heart rate decreased over time, and those in experimental groups were lower than those in control group, with significant differences (P<0.05). Before treatment, there were no significant differences in VO2Peak , AT, Met peak and VE peak between the experimental group and the control group. After treatment, VO2Peak , AT, Met Peak and VE Peak in experimental group and control group increased with time, and the difference was significant (P<0.05). Before treatment, there were no significant differences in FMA and MBI scores between the experimental group and the control group. After treatment, the scores of FMA and MBI in experimental group and control group increased with the passage of time, and those in experimental group were higher than those in control group, with significant differences (P<0.05). Conclusion: The clinical effect of cardiopulmonary rehabilitation training is better in patients with cerebral apoplexy, which can improve the patients' serum BDNF, NT-3, MMP-9 and cardiopulmonary function. |
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