| 刘天骄,王晓菲,张田田,周 静,张 欣.葛兰心宁软胶囊联合替格瑞洛片对冠心病心绞痛患者心功能和血管内皮功能的影响[J].现代生物医学进展英文版,2022,(4):651-654. |
| 葛兰心宁软胶囊联合替格瑞洛片对冠心病心绞痛患者心功能和血管内皮功能的影响 |
| Effects of Gelan Xinning Soft Capsule Combined with Ticagrelor Tablets on Cardiac Function and Vascular Endothelial Function in Patients with Angina Pectoris of Coronary Heart Disease |
| Received:June 22, 2021 Revised:July 18, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.04.011 |
| 中文关键词: 葛兰心宁软胶囊 替格瑞洛片 冠心病心绞痛 心功能 血管内皮功能 |
| 英文关键词: Gelan Xinning soft capsule Ticagrelor tablets Angina pectoris of coronary heart disease Cardiac function Vascular endothelial function |
| 基金项目:上海科学技术委员会科研计划项目（18411950500） |
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| 中文摘要: |
| 摘要 目的：观察葛兰心宁软胶囊联合替格瑞洛片治疗冠心病心绞痛的疗效及对心功能和血管内皮功能的影响。方法：选择我院心内科收治的150例冠心病心绞痛患者，按门诊号单双数分为对照组和研究组，各为75例。对照组给予替格瑞洛片治疗，研究组给予葛兰心宁软胶囊联合替格瑞洛片治疗，对比两组疗效、血管内皮功能、心功能、心绞痛发作次数和持续时间以及不良反应发生率。结果：治疗1个月后，研究组的临床总有效率85.33%（64/75）高于对照组的69.33%（52/75），差异有统计学意义（P<0.05）。治疗1个月后，研究组左心室射血分数（LVEF）、心输出量（CO）、每搏输出量（SV）高于对照组（P<0.05）。治疗1个月后，与对照组比较，研究组的心绞痛发作次数更少，持续时间更短（P<0.05）。治疗1个月后，研究组一氧化氮（NO）、血流介导的舒张功能（FMD）高于对照组，内皮素-1（ET-1）、胞间黏附分子-1（ICAM-1）、血管紧张素Ⅱ（Ang Ⅱ）低于对照组（P<0.05）。两组不良反应发生率组间对比无明显差异（P>0.05）。结论：冠心病心绞痛患者经葛兰心宁软胶囊联合替格瑞洛片治疗后，疗效明确，可缓解患者临床症状，促进心功能和血管内皮功能恢复。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the efficacy of Gelan Xinning soft capsule combined with ticagrelor tablets on angina pectoris of coronary heart disease and the effect on cardiac function and vascular endothelial function. Methods: 150 patients with angina pectoris of coronary heart disease who were admitted to the Department of Cardiology of our hospital were selected, they were divided into the control group and the study group according to the odd and even number of outpatient number, with 75 cases in each group. The control group was treated with ticagrelor tablets, and the study group was treated with Gelan Xinning soft capsule combined with ticagrelor tablets. The efficacy, vascular endothelial function, cardiac function, angina pectoris attack times and duration time, adverse reactions rate were compared between the two groups. Results: 1 month after treatment, the total effective rate of the study group 85.33% (64/75) was higher than 69.33% (52/75) of the control group, difference was statistically significant (P<0.05). 1 month after treatment, the left ventricular ejection fraction (LVEF), cardiac output (CO), and stroke volume (SV) of the study group were higher than those in the control group (P<0.05). 1 month after treatment, compared with the control group, the angina pectoris attack times of the study group was less, and the duration time was shorter (P<0.05). 1 month after treatment, the nitric oxide (NO), flow mediated diastolic function (FMD) of the study group were higher than those of the control group, and endothelin-1 (ET-1), intercellular adhesion molecule-1 (ICAM-1), angiotensin II (Ang Ⅱ) was lower than those of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The patients with angina pectoris of coronary heart disease are treated with Gelan Xinning soft capsule combined with ticagrelor tablets, the efficacy is clear. It can relieve the clinical symptoms and promote the recovery of cardiac function and vascular endothelial function. |
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