| 马争发,张丽杰,余甜甜,张 湄,谭维群.聚苹果酸及其衍生物的制备与应用研究进展[J].现代生物医学进展英文版,2022,(3):592-600. |
| 聚苹果酸及其衍生物的制备与应用研究进展 |
| Progress in the Preparation and Application of Polymalic Acid and Its Derivatives |
| Received:December 28, 2021 Revised:January 23, 2022 |
| DOI：10.13241/j.cnki.pmb.2022.03.041 |
| 中文关键词: 聚苹果酸 高分子聚酯 衍生物 生物相容性 完全生物降解性 |
| 英文关键词: Polymalic acid Polymer polyester Derivatives Biocompatibility Complete biodegradability |
| 基金项目:国家自然科学基金项目（41502328） |
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| 中文摘要: |
| 摘要：天然和合成聚合物因优良的特性引起了越来越多研究者的兴趣，并已被广泛用于人类的日常生活中。聚苹果酸（Polymalic acid，PMLA）一种天然的高分子聚酯材料，具有良好的生物相容性和完全生物降解性，其衍生物同样具有优异的生物学性能，被广泛应用于众多领域中。本文就聚苹果酸及其衍生物的结构、性质和合成方法进行了概述，并全面总结了其在制药和其他领域的应用研究现状，最后对未来发展方向进行了展望。 |
| 英文摘要: |
| ABSTRACT: Natural and synthetic polymers have attracted interests of increasing researchers due to their excellent properties, and also have been widely used in human daily life. Polymalic acid (PMLA) is a natural polymer polyester material with a good biocompatibility and complete biodegradability. Its derivatives also have excellent biological properties and hence are widely used in many fields. The structure, performance and synthetic methods of PMLA and its derivatives have been overviewed in this article. Meanwhile the application research status in pharmaceutical and other fields was comprehensively summarized. Finally the future development direction was prospected. |
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