| 王 唯,卓益民,厚玉姣,石晓静,吉王琦,韩 易.盐酸多奈哌齐联合综合康复训练对老年痴呆患者认知功能、事件相关电位及血清BDNF、IGF-1的影响[J].现代生物医学进展英文版,2022,(1):99-102. |
| 盐酸多奈哌齐联合综合康复训练对老年痴呆患者认知功能、事件相关电位及血清BDNF、IGF-1的影响 |
| Effects of Donepezil Hydrochloride Combined with Comprehensive Rehabilitation Training on Cognitive Function, Event-Related Potential and Serum BDNF, IGF-1 in Patients with Senile Dementia |
| Received:June 19, 2021 Revised:July 13, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.01.017 |
| 中文关键词: 盐酸多奈哌齐 综合康复训练 老年痴呆 认知功能 事件相关电位 BDNF IGF-1 |
| 英文关键词: Donepezil hydrochloride Comprehensive rehabilitation training Senile dementia Cognitive function Event-related potential BDNF IGF-1 |
| 基金项目:上海市自然科学基金项目(15ZR1414600) |
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| 中文摘要: |
| 摘要 目的：探讨盐酸多奈哌齐联合综合康复训练对老年痴呆患者认知功能、事件相关电位及血清脑源性神经营养因子（BDNF）、胰岛素样生长因子1（IGF-1）的影响。方法：选取2017年3月~2020年3月期间来我院接受治疗的120例老年痴呆患者，根据随机数字表法分为对照组（n=60，盐酸多奈哌齐治疗）和联合组（n=60，盐酸多奈哌齐联合综合康复训练治疗）。对比两组疗效，治疗前、治疗3个月后的认知功能评分、事件相关电位、血清BDNF和IGF-1水平变化，以及治疗期间不良反应发生情况。结果：联合组的临床总有效率为91.67%，高于对照组的70.00%（P<0.05）。两组治疗3个月后日常生活能力评估量表（ADL）、临床痴呆量表（CDR）评分降低，且联合组低于对照组（P<0.05）；简易精神状态量表（MMSE）评分升高，且联合组高于对照组（P<0.05）。两组治疗3个月后N1潜伏期、P2潜伏期均缩短，P3波幅均升高，且联合组治疗3个月后P2潜伏期短于对照组，P3波幅高于对照组（P<0.05）；两组治疗3个月后N1潜伏期比较未见统计学差异（P>0.05）。联合组治疗3个月后BDNF水平高于对照组（P<0.05）；两组治疗3个月后IGF-1水平比较未见统计学差异（P>0.05）。对照组与联合组不良反应发生率对比无统计学差异（P>0.05）。结论：老年痴呆患者在盐酸多奈哌齐基础上联合综合康复训练，认知功能可得到明显改善，同时还可调节患者事件相关电位及血清BDNF、IGF-1水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of donepezil hydrochloride combined with comprehensive rehabilitation training on cognitive function, event-related potential and serum brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) in patients with senile dementia. Methods: 120 patients with senile dementia who were treated in our hospital from March 2017 to March 2020 were selected, they were divided into control group (n=60, donepezil hydrochloride treatment) and combination group (n=60, donepezil hydrochloride combined with comprehensive rehabilitation training treatment) according to random number table method. The efficacy, cognitive function scores, event-related potential and serum BDNF, IGF-1 before and 3 months after treatment, and the occurrence of adverse reactions during treatment of the two groups were compared. Results: The total effective rate of the combination group was 91.67%, which was higher than 72.92% of the control group (P<0.05). The scores of activities of daily living (ADL) assessment scale, clinical dementia rating (CDR) in both groups decreased, and the combination group was lower than the control group (P<0.05), the scores of Mini Mental State Scale (MMSE) increased,, and the combination group was higher than that of the control group (P<0.05). N1 latency and P2 latency shortened, P3 amplitude increased in the two groups at 3 months after treatment, and the P2 latency in the combination group was shorter than that in control group at 3 months after treatment, P3 amplitude was higher than that in control group (P<0.05), there was no significant difference in N1 latency between the two groups at 3 months after treatment (P>0.05). The level of BDNF in the combination group at 3 months after treatment was significantly higher than that in control group (P<0.05), there was no significant difference in IGF-1 level of the two groups at 3 months after treatment (P>0.05). There was no statistical difference in the incidence of adverse reactions between control group and combination group (P>0.05). Conclusion: Combined with comprehensive rehabilitation training on the basis of donepezil hydrochloride, the cognitive function of patients with senile dementia can be significantly improved. At the same time, it can also adjust the event-related potential and the levels of serum BDNF and IGF-1. |
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