| 朱 筱,李艳波,刘国磊,刘德情,肖 平,秦佳俊,李 萍,陈 波.甲基强的松龙治疗2型糖尿病合并突发性感音神经聋的临床疗效研究[J].现代生物医学进展英文版,2022,(1):78-82. |
| 甲基强的松龙治疗2型糖尿病合并突发性感音神经聋的临床疗效研究 |
| Clinical Study of Methylprednisolone in Treatment of Type 2 Diabetes Complicated with Sudden Sensorineural Hearing Loss |
| Received:June 15, 2021 Revised:July 10, 2021 |
| DOI：10.13241/j.cnki.pmb.2022.01.013 |
| 中文关键词: 甲基强的松龙 2型糖尿病 突发性感音神经聋 疗效 |
| 英文关键词: Methylprednisolone Type 2 Diabetes Mellitus Sudden sensorineural hearing loss Curative effect |
| 基金项目:广东省科技计划项目基金资助项目（2017A020215189）；广州市科学技术协会科普项目（K20210702008） |
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| 中文摘要: |
| 摘要 目的：观察甲基强的松龙治疗2型糖尿病合并突发性感音神经聋患者的治疗效果。方法：本研究共纳入2018年1月至2020年10月期间于深圳大学附属华南医院内分泌科、耳鼻喉科住院治疗的60例合并单侧突发性感音神经聋的成人2型糖尿病患者，按照随机数字表法分为治疗组（n=30）和对照组（n=30）。两组患者均给予营养神经、胰岛素降糖和高压氧治疗，治疗组给予甲基强的松龙静脉滴注3日后，减少甲基强的松龙剂量继续治疗4天，两组总疗程为14天。观察两组患者治疗后听力障碍改善情况，两组患者分别于治疗开始前、治疗1周后、治疗2周后分别测定纯音听阈均值（ PTA）、听性脑干反应( ABR)以评估治疗效果。结果：治疗2周后治疗组听力障碍分级优于对照组（P<0.05）；治疗2周后，治疗组的PTA和70dB、80dB、90dB声波刺激ABR指标均优于对照组（P<0.05）。结论：甲基强的松龙联合营养神经、降糖和高压氧等综合治疗，可有效提高2型糖尿病合并突发性感音神经聋患者的听力，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the therapeutic effect of methylprednisolone in treatment of type 2 diabetes mellitus complicated with sudden sensorineural hearing loss. Methods: A total of 60 adult type 2 diabetic patients with unilateral sudden acoustic deafness who were hospitalized in the Department of Endocrine and Otorhinolaryngology of South China Hospital Affiliated to Shenzhen University from January 2018 to October 2020 were enrolled in this study. According to random number table method, they were divided into treatment group (n=30) and control group (n=30). Patients in both groups were treated with neurotrophic therapy, insulin hypoglycemic therapy and hyperbaric oxygen therapy. After 3 days of intravenous infusion of methylprednisolone, the dose of methylprednisolone was reduced and continued treatment for 4 days. The total course of treatment in both groups was 14 days. The improvement of hearing impairment after treatment was observed, Pure tone average (PTA) and auditory brainstem response (ABR) of two wo groups of patients were measured before treatment, 1 week after treatment and 2 weeks after treatment, respectively, to evaluate the treatment effect. Results: 2 weeks after treatment, the grade of hearing impairment in the treatment group was better than that in the control group (P<0.05). 2 weeks after treatment, PTA and ABR indexes stimulated by 70dB, 80dB and 90dB sound waves in the treatment group were better than those in the control group (P<0.05). Conclusion: Combined therapy with methylprednisolone and nutritional nerve, hypoglycemic and hyperbaric oxygen can effectively improve the hearing of patients with type 2 diabetes mellitus complicated with sudden sensorineural hearing loss, and is worthy of clinical application. |
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