| 马 明,谭小田,李嫣红,谢华宁,高 娜,路晓艳,卫 国.温阳益气汤对阳虚血瘀证慢性心力衰竭患者血清sST2及GDF-15的影响[J].现代生物医学进展英文版,2021,(24):4760-4764. |
| 温阳益气汤对阳虚血瘀证慢性心力衰竭患者血清sST2及GDF-15的影响 |
| Effect of Wenyang Yiqi Decoction on Serum ST2 and GDF-15 in Patients with Chronic Heart Failure of Yang Deficiency and Blood Stasis Syndrome |
| Received:March 28, 2021 Revised:April 24, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.24.033 |
| 中文关键词: 温阳宜气汤 阳虚血瘀证 慢性心力衰竭 sST2 GDF-15 |
| 英文关键词: Wenyangyiqi Decoction Yang deficiency and blood stasis syndrome Chronic heart failure sST2 GDF-15 |
| 基金项目:陕西省重点研发计划项目（2018SF-346） |
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| 中文摘要: |
| 摘要 目的：探讨温阳益气汤对阳虚血瘀证慢性心力衰竭患者血清可溶性ST2（sST2）及血清生长分化因子15（GDF-15）的影响。方法：以2019.2-2020.5于我院就诊的慢性心力衰竭患者133例为研究对象，随机平均分为对照组（常规西医治疗）和观察组（在对照组的基础上给于温阳益气汤治疗）。观察并记录两组患者治疗效果和不良反应，心脏彩超仪器检测心功能指标（SV、CO、LVEF、LVED），ELISA法检测血清sST2及GDF-15的表达水平，生活质量评分量表评价患者生活质量。结果：（1）观察组总有效率显著高于对照组（P<0.05）；（2）治疗后两组以上指标均较治疗前显著增加（P<0.05），且治疗后观察组SV、CO、LVEF均较对照组显著增加（P<0.05），而LVED无显著变化（P＞0.05）；（3）治疗后两组患者sST2、GDF-15均较治疗前显著降低（P<0.05），且观察组以上指标均较对照组显著降低（P<0.05）；（4）治疗前两组患者社会领域、身躯领域、情绪领域、经济领域得分差异无统计学意义（P>0.05），治疗后两组患者社会领域、身躯领域、情绪领域、经济领域得分均较治疗前显著增加，且治疗后观察组以上评分也显著高于对照组（P<0.05）。结论：温阳宜气汤能使sST2、GDF-15表达降低，改善患者心功能和生活质量，疗效佳，具有一定临床参考意义。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of Wenyang Yiqi Decoction on serum soluble ST2(sst2) and serum growth differentiation factor 15(GDF-15) in patients with chronic heart failure of Yang deficiency and blood stasis syndrome. Methods: 133 patients with chronic heart failure treated in our hospital from February 2019 to May 2020 were taken as the research object, and randomly divided into a control group (conventional Western medicine treatment) and an observation group (on the basis of the control group given to Wenyang Yiqi Decoction). The treatment effects and adverse reactions of the two groups of patients were observed and recorded, Cardiac ultrasound equipment is used to detect cardiac function indicators(SV, CO, LVEF, LVED), Cardiac color Doppler ultrasound instrument detects cardiac function indexes(SV, CO, LVEF, LVED), ELISA method was used to detect the expression levels of serum sST2 and GDF-15, and the quality of life score scale was used to evaluates the quality of life of patients. Results: (1) The total effective rate of the observation group was significantly higher than that of the control group (P<0.05); (2) After treatment, more than two groups of indicators were significantly increased(P<0.05), and after treatment, the observation group SV, CO, LVEF were significantly lower than the control group(P<0.05), but there is no significant change in LVED (P>0.05); (3) After treatment, sST2 and GDF-15 in both groups were significantly lower than before treatment(P<0.05), and the above indicators in the observation group were significantly lower than those in the control group(P<0.05); (4) There was no statistically significant difference in scores in the social, physical, emotional, and economic fields between the two groups before treatment(P>0.05), after treatment, the scores of the social, physical, emotional, and economic fields of the two groups of patients increased significantly compared with those before treatment, and the scores above the observation group after treatment were also significantly higher than those of the control group(P<0.05). Conclusion: Wenyangyiqi decoction can reduce the expression of ST2 and GDF-15, improve the heart function and quality of life of patients, and has good curative effect, which has certain clinical reference significance. |
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