| 陈金辉,罗 斌,姚黎辉,张 策,袁 立.脑胶质瘤组织长链非编码RNA FTX、RHPN1-AS1表达与预后的关系[J].现代生物医学进展英文版,2021,(24):4742-4746. |
| 脑胶质瘤组织长链非编码RNA FTX、RHPN1-AS1表达与预后的关系 |
| Relationship between the Expression of Long Non-Coding RNA FTX, RHPN1-AS1 and Prognosis in Glioma Tissu |
| Received:April 17, 2021 Revised:May 13, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.24.029 |
| 中文关键词: 脑胶质瘤 长链非编码核糖核酸 FTX RHPN1-AS1 预后 |
| 英文关键词: Glioma Long non-coding ribonucleic acid FTX RHPN1-AS1 Prognosis |
| 基金项目:广东省科学技术厅公益研究和能力建设专项（2014A020212380） |
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| 中文摘要: |
| 摘要 目的：探讨脑胶质瘤组织长链非编码核糖核酸(LncRNA) FTX、RHPN1-AS1表达与预后的关系。方法：选取我院105例脑胶质瘤患者手术切除的癌组织和癌旁组织（距离肿瘤边缘3~5 cm）。采用实时荧光定量PCR（qRT-PCR）检测组织中LncRNA FTX、RHPN1-AS1表达。分析LncRNA FTX、RHPN1-AS1表达与脑胶质瘤患者临床病理特征的关系。K-M法绘制不同LncRNA FTX、RHPN1-AS1表达脑胶质瘤患者术后5年无进展生存期和总生存期曲线。Cox回归分析脑胶质瘤患者预后不良的影响因素。结果：脑胶质瘤组织中LncRNA FTX、RHPN1-AS1表达水平高于癌旁组织(P＜0.05)。LncRNA FTX、RHPN1-AS1表达与脑胶质瘤患者卡氏体力状态(KPS)评分和世界卫生组织(WHO)分级相关(P＜0.05)。LncRNA FTX、RHPN1-AS1高表达组无进展生存期和总生存期均短于低表达组(P＜0.05)。KPS评分(HR=2.621，95%CI：1.284～5.348)、WHO分级(HR=2.264，95%CI：1.152～4.449)、LncRNA FTX(HR=1.997，95%CI：1.017～3.922)、LncRNA RHPN1-AS1(HR=2.431，95%CI：1.257～4.701)均是脑胶质瘤患者预后不良的影响因素(P＜0.05)。结论：脑胶质瘤组织中LncRNA FTX、RHPN1-AS1表达水平升高，且二者与KPS评分、WHO分级均是患者预后不良的影响因素，可用于脑胶质瘤患者预后评估。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between long non-coding ribonucleic acid (LncRNA) FTX, RHPN1-AS1 expression and prognosis in glioma tissue. Methods: A total of 105 cases of glioma patients in our hospital were selected from the surgically resected cancerous tissues and adjacent cancerous tissues (3~5cm from the tumor edge). Real-time quantitative reverse transcription PCR (qRT-PCR) was used to detect the expression of LncRNA FTX and RHPN1-AS1 in tissues. The relationship between LncRNA FTX and RHPN1-AS1 expression and clinicopathological features of glioma were analyzed. The 5-year progression-free survival time and overall survival time of glioma patients with different LncRNA FTX and RHPN1-AS1 expression were plotted by K-M method. Factors influencing poor prognosis in glioma patients were analyzed by Cox regression. Results: LncRNA FTX, RHPN1-AS1 expression levels in glioma tissues was higher than those in adjacent tissues(P＜0.05). LncRNA FTX, RHPN1-AS1 expression was correlated with Karnofsky Performance Status (KPS) score and World Health Organization (WHO) classification in glioma patients (P＜0.05). Progression-free survival time and overall survival time were shorter in the LncRNA FTX, RHPN1-AS1 high expression group than those in the low expression group (P＜0.05). KPS score (HR=2.621, 95%CI: 1.284～5.348), WHO classification (HR=2.264, 95%CI: 1.152～4.449), LncRNA FTX (HR=1.997, 95%CI: 1.017～3.922), and LncRNA RHPN1-AS1 (HR=2.431, 95%CI: 1.257～4.701) were influence factors for poor prognosis in glioma patients(P＜0.05). Conclusion: The expression levels of LncRNA FTX and RHPM1-AS1 in glioma tissues were increased, and both of them, KPS score and WHO grade were factors influencing the poor prognosis of patients, which could be used to evaluate the prognosis of glioma patients. |
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