| 白翠林,贾李侠,李 宁,同思雅,纪玉强.老年肺炎患者血清Apelin-13水平与疾病严重程度和预后的相关性研究[J].现代生物医学进展英文版,2021,(23):4554-4558. |
| 老年肺炎患者血清Apelin-13水平与疾病严重程度和预后的相关性研究 |
| Study on the Correlation between Serum Apelin-13 Level and Disease Severity and Prognosis in Elderly Patients with Pneumonia |
| Received:April 08, 2021 Revised:April 30, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.23.033 |
| 中文关键词: 老年人肺炎 Apelin-13 急性生理学及慢性健康状况评分系统 |
| 英文关键词: Elderly pneumonia Apelin-13 Acute physiology and chronic health status scoring system |
| 基金项目:陕西省重点研发计划项目（一般项目）（2021SF-151） |
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| 中文摘要: |
| 摘要 目的：探讨与研究老年肺炎患者血清Apelin-13水平与疾病严重程度和预后的相关性。方法：采用回顾性研究方法，2018年3月到2021年2月选择在延安大学咸阳医院住院诊治的老年肺炎患者78例作为研究对象，检测血清Apelin-13水平，使用急性生理学及慢性健康状况评分系统（APACHEⅡ）、CT严重程度指数（CTSI）、序贯性器官功能衰竭评分（SOFA）评定患者的疾病严重程度，随访患者的预后并进行相关性分析。结果：所有患者随访到2021年7月1日，平均随访时间为18.47±2.82个月，死亡18例（死亡组），占比23.1 %。死亡组的性别、年龄、生活行为、体重指数、病程、合并疾病等与非死亡组对比无差异（P>0.05），但血清Apelin-13表达水平具有差异，且死亡组较非死亡组低（P<0.05）。死亡组的APACHEⅡ评分、SOFA评分、CTSI评分高于非死亡组（P<0.05）。在78例患者中，Pearson分析显示血清Apelin-13水平与APACHEⅡ评分、SOFA评分、CTSI评分存在负相关性（P<0.05）。多因素logistic回归分析显示：血清Apelin-13水平（OR=3.770）、APACHEⅡ评分（OR=3.624）、SOFA评分（OR=2.422）、CTSI评分（OR=1.842）都为影响患者预后死亡的重要因素（P<0.05）。结论：老年肺炎患者血清Apelin-13水平呈现低表达状况，与患者的APACHEⅡ评分、SOFA评分、CTSI评分等疾病严重程度指标存在相关性，也是影响患者预后死亡的重要因素。 |
| 英文摘要: |
| ABSTRACT Objective: To explore and study the correlation between serum Apelin-13 level and disease severity and prognosis in elderly patients with pneumonia. Methods: Used retrospective research methods, from March 2018 to February 2021, 78 cases of elderly patients with pneumonia who were hospitalized in Xianyang Hospital of Yan 'an University were selected as the research subjects. The serum Apelin-13 levels were detected and the APACHE Ⅱ, CTSI, SOFA were used to assess the severity of the patient's disease, followed up the prognosis of the patient and given correlation analysis. Results: All patients were followed up until July 1, 2021. The average follow-up time were 18.47±2.82 months. There were 18 cases were died (death group), accounted for 23.1 %. The gender, age, life behavior, body mass index, course of disease, and co-morbidities of the death group showed no difference compared with the non-death group(P>0.05), but the expression level of serum Apelin-13 in the death group was lower than that in the non-death group (P<0.05). The APACHEⅡ scores, CTSI scores and SOFA scores of the death group were higher than that of the non-death group (P<0.05). In the 78 patients, Pearson analysis showed that there were negative correlation between serum Apelin-13 level and APACHEⅡ scores, CTSI scores and SOFA scores. Logistic regression analysis showed that serum Apelin-13 level (OR=3.770), APACHEⅡ score (OR=3.624), CTSI scores (OR=2.422) and SOFA scores (OR=1.842) were important factors affected the prognosis of death (P<0.05). Conclusion: The level of serum Apelin-13 in elderly patients with pneumonia presents low expression state, which are correlated with the APACHEⅡ scores, CTSI scores and SOFA scores of the patient, and are also important factors affecting the prognosis and death of the patient. |
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