| 刘 佳,朱爱华,吴艳杰,盛佳曦,柳 洋.血清HBP、uNAG及Lp-PLA2在糖尿病酮症酸中毒患者中的表达及与病情程度的相关性分析[J].现代生物医学进展英文版,2021,(22):4326-4330. |
| 血清HBP、uNAG及Lp-PLA2在糖尿病酮症酸中毒患者中的表达及与病情程度的相关性分析 |
| Analysis of the Expression of Serum HBP, UNAG and Lp-PLA2 in Patients with Diabetic Ketoacidosis and Its Correlation with the Degree of Disease |
| Received:April 23, 2021 Revised:May 18, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.22.026 |
| 中文关键词: 肝素结合蛋白 N-乙酰-β-D-氨基葡萄糖苷酶 脂蛋白相关磷脂酶A2 糖尿病酮症酸中毒 病情程度 相关性 |
| 英文关键词: Heparin binding protein N-acetyl-β-D-glucosaminosidase Lipoprotein-associated phospholipase A2 Diabetic ketoacidosis Degree of illness The correlation |
| 基金项目:河北省科学技术厅科技攻关项目(08276101D-48) |
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| 中文摘要: |
| 摘要 目的：探讨血清肝素结合蛋白（HBP）、N-乙酰-β-D-氨基葡萄糖苷酶（uNAG）及脂蛋白相关磷脂酶A2（Lp-PLA2）在糖尿病酮症酸中毒患者中的表达及与病情程度的相关性。方法：选择2018年3月至2020年3月于我院进行治疗的78例糖尿病酮症酸中毒患者进行研究，设为病例组，并选择我院同期治疗的单纯糖尿病患者70例作为对照组，分析血清HBP、uNAG及Lp-PLA2水平变化情况及与病情程度的相关性及其预测价值。结果：病例组血清HBP、uNAG及Lp-PLA2水平显著高于对照组，差异显著（P＜0.05）；轻度组血清HBP、uNAG及Lp-PLA2显著低于中度组、重度组患者，中度组HBP、uNAG及Lp-PLA2显著低于重度组患者，差异显著（P＜0.05）；相关性分析结果中显示，血清HBP、uNAG及Lp-PLA2均和病情程度之间呈正相关（P＜0.05）；ROC结果显示，血清HBP预测糖尿病酮症酸中毒的AUC为0.804，灵敏度为82.56%，特异度为86.32%，截断值为59.92 ng/mL；uNAG预测糖尿病酮症酸中毒的AUC为0.886，灵敏度为83.48%，特异度为87.95%，截断值为12.53 IU/L；血清Lp-PLA2预测糖尿病酮症酸中毒的AUC为0.977，灵敏度为88.69%，特异度为89.97%，截断值为194.96 ng/L，（P＜0.05）。结论：血清HBP、uNAG及Lp-PLA2在糖尿病酮症酸中毒患者中表达异常，与病情程度之间关系密切，对于病情控制具有重要临床意义。 |
| 英文摘要: |
| ABSTRACT Objective: To study Analysis of theExpression of serum Heparin binding protein (HBP), N-acetyl-β-D-glucosaminosidase (UNAG) and lipoprotein associated phospholipase A2 (LP-PLA2) in patients with diabetic ketoacidosis and its correlation with the degree of disease. Methods: 78 patients with diabetic ketoacidosis who were treated in our hospital from March 2018 to March 2020 were selected as the case group, and 70 patients with simple diabetes who were treated in our hospital during the same period were selected as the control group. The changes of serum HBP, UNAG and Lp-PLA2 levels and their correlation with the severity of the disease and their prediction value were analyzed. Results: The serum levels of HBP, UNAG and Lp-PLA2 in case group were significantly higher than those in control group, and the differences were significant (P<0.05). Serum HBP, UNAG and Lp-PLA2 in mild group were significantly lower than those in moderate and severe group, and HBP, UNAG and Lp-PLA2 in moderate group were significantly lower than those in severe group, the difference was significant(P<0.05). Correlation analysis showed that serum HBP, UNAG and Lp-PLA2 were positively correlated with the severity of the disease(P<0.05). ROC results showed that the AUC of serum HBP for predicting diabetic ketoacidosis was 0.804, the sensitivity was 82.56%, the specificity was 86.32%, and the cutoff value was 59.92 ng/mL. The AUC of UNAG for predicting diabetic ketoacidosis was 0.886, the sensitivity was 83.48%, the specificity was 87.95%, and the cut-off value was 12.53 IU/L. The AUC of serum Lp-PLA2 for predicting diabetic ketoacidosis was 0.977, the sensitivity was 88.69%, the specificity was 89.97%, and the cut-off value was 194.96 ng/L(P<0.05). Conclusion: The abnormal expression of serum HBP, UNAG and Lp-PLA2 in patients with diabetic ketoacidosis is closely related to the severity of the disease, which has important clinical significance for the control of the disease. |
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