| 殷 娜,汤锋武,符 锋,韩 广,邢 军.低强度脉冲聚焦超声联合等速肌力训练对膝骨关节炎患者膝关节本体感觉、生活质量和炎性因子水平的影响[J].现代生物医学进展英文版,2021,(22):4275-4278. |
| 低强度脉冲聚焦超声联合等速肌力训练对膝骨关节炎患者膝关节本体感觉、生活质量和炎性因子水平的影响 |
| Effects of Low Intensity Pulsed Focused Ultrasound Combined with Isokinetic Muscle Strength Training on Knee Proprioception, Quality of Life and Inflammatory Factors Levels in Patients with Knee Osteoarthritis |
| Received:March 05, 2021 Revised:March 28, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.22.015 |
| 中文关键词: 低强度脉冲聚焦超声 等速肌力训练 膝骨关节炎 膝关节本体感觉 生活质量 炎性因子 |
| 英文关键词: Low intensity pulsed focused ultrasound Isokinetic muscle strength training Knee osteoarthritis Knee proprioception Quality of life Inflammatory factors |
| 基金项目:天津市科技计划项目（16ZXHLSY00120） |
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| 中文摘要: |
| 摘要 目的：探讨低强度脉冲聚焦超声联合等速肌力训练对膝骨关节炎（KOA）患者膝关节本体感觉、生活质量和炎性因子水平的影响。方法：选取2017年1月~2019年10月期间我院收治的KOA患者70例。采用随机数字表法将患者分为对照组（n=35，常规药物治疗、物理治疗）和实验组（n=35，常规药物治疗基础上给予等速肌力训练联合低强度脉冲聚焦超声治疗），对比两组膝关节本体感觉、病情严重程度、膝关节功能、炎性因子和生活质量。结果：治疗2个月后，两组Le-quence指数、西安大略和麦克马斯特大学骨关节炎调查量表(WOMAC)评分均低于同组治疗前，且实验组低于对照组（P<0.05）；治疗2个月后，两组健康调查简表(SF-36量表)各维度评分均高于同组治疗前，且实验组高于对照组（均P<0.05）。治疗2个月后，实验组主动角度重现测试值（AAR）、被动运动阈值测量值（TDPM）低于同组治疗前，且低于对照组（P<0.05）。治疗2个月后，两组白介素-1β（IL-1β）及肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）均低于同组治疗前，且实验组低于对照组（P<0.05）。结论：等速肌力训练联合低强度脉冲聚焦超声治疗KOA，可促进症状改善，降低炎症因子水平，并提高膝关节功能及生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of low intensity pulsed focused ultrasound combined with isokinetic muscle strength training on knee proprioception, quality of life and inflammatory factors levels in patients with knee osteoarthritis (KOA). Methods: 70 patients with KOA in our hospital from January 2017 to October 2019 were selected. The patients were randomly divided into control group (n=35, conventional drug therapy, physical therapy) and experimental group (n=35, isokinetic muscle strength training combined with low intensity pulsed focused ultrasound on the basis of conventional drug therapy) by random number table method. The knee proprioception, disease degree, knee function, inflammatory factor and quality of life of the two groups were compared. Results: 2 months after treatment, the Le-equence index, Western Ontario and McMaster University Osteoarthritis Inventory (WOMAC) score of the two groups were lower than before treatment, and the experimental group was lower than the control group(P<0.05). 2 months after treatment, the scores of all dimensions of item short from health survey(SF-36) of the two groups were higher than those before treatment, and the experimental group was higher than the control group(all P<0.05). 2 months after treatment, active angle reproduction test value (AAR) and passive motion threshold measurement (TDPM) of the experimental group were lower than those before treatment in the same group, and lower than those in the control group(P<0.05). 2 months after treatment, the interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) of the two groups were lower than those before treatment in the same group, and the experimental group were lower than the control group(P<0.05). Conclusion: Isokinetic muscle strength training combined with low intensity pulsed focused ultrasound in the treatment of KOA can promote symptom improvement, reduce inflammatory cytokines, and improve knee function and quality of life. |
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