| 王 林,姚碧波,陈振华,邹芳芳,彭 娜.NLR、RDW和PCT评估老年社区获得性肺炎患者病情严重程度及预后的临床价值[J].现代生物医学进展英文版,2021,(21):4181-4184. |
| NLR、RDW和PCT评估老年社区获得性肺炎患者病情严重程度及预后的临床价值 |
| Clinical Value of NLR, RDW and PCT in Evaluating the Severity of Illness and Prognosis of Elderly Patients With Community-Acquired Pneumonia |
| Received:April 03, 2021 Revised:April 27, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.21.038 |
| 中文关键词: 老年 社区获得性肺炎 NLR RDW PCT 病情 预后 |
| 英文关键词: Elderly Community-acquired pneumonia NLR RDW PCT Illness Prognosis |
| 基金项目:湖南省自然科学基金项目（2019JJ80044） |
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| 中文摘要: |
| 摘要 目的：探讨中性粒细胞/淋巴细胞比值（NLR）、红细胞分布宽度（RDW）及降钙素原（PCT）在老年社区获得性肺炎（CAP）患者病情严重程度及预后评估中的临床价值。方法：回顾性分析2018年1月～2020年11月期间我院收治的127例老年CAP患者的临床资料，根据英国胸科协会改良肺炎评分(CURB-65)分为低危组（CURB-65评分＜3分，n=69例）和高危组（CURB-65评分≥3分，n=58例）；根据患者转归分为存活组（n=114例）和死亡组（n=13例），比较各组患者的基线资料、NLR、RDW、PCT及其他实验室检查指标，并分析NLR、RDW、PCT与CURB-65评分的相关性以及预后的影响因素。结果：高危组NLR、RDW和 PCT水平均显著高于低危组，差异有统计学意义（P＜0.05）。经Pearson相关性分析可得：NLR、RDW、PCT与CURB-65评分均呈正相关关系（P＜0.05）。生存组患者白细胞计数（WBC）、中性粒细胞（NEU）、NLR、RDW、PCT和D-二聚体（D-Dimer）水平均低于死亡组，差异具有统计学意义（P＜0.05），经多因素Logistic回归分析可得：NLR、RDW、PCT均是老年CAP患者预后的影响因素（均OR＞1，P＜0.05）。结论：NLR、RDW和PCT与CURB-65评分相关，且均是老年CAP患者预后的影响因素，NLR、RDW和PCT对老年CAP患者病情严重程度及预后具有一定的评估价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical value of neutrophil/lymphocyte ratio (NLR), red blood cell distribution width (RDW) and procalcitonin (PCT) in evaluating the severity of illness and prognosis of elderly patients with community-acquired pneumonia (CAP). Methods: Clinical data of 127 elderly patients with CAP who were admitted to our hospital from January 2018 to November 2020 were retrospectively analyzed. According to the confusion, uremia, respiratory, BP, age 65 years (CURB-65 score), the patients were divided into low-risk group (CURB-65 score < 3 scores, n=69 cases) and high-risk group (CURB-65 score ≥3 scores, n=58 cases). According to their outcomes, the patients were divided into survival group (n=114 cases) and death group (n=13 cases). The clinical baseline data, NLR, RDW, PCT and other relevant laboratory examination indexes of each group were compared, and the correlation between NLR, RDW, PCT and CURB-65 were analyzed, and the evaluation value of NLR, RDW and PCT for the severity of illness and prognosis of elderly patients with CAP were evaluated. Results: The levels of NLR, RDW and PCT in high-risk group were significantly higher than those in low-risk group, with statistical significance (P<0.05). Pearson correlation analysis showed that NLR, RDW, PCT and CURB-65 were positively correlated (P<0.05). The levels of White blood cell count (WBC), Neutrophils (NEU), NLR, RDW, PCT and D-Dimer in the death group were significantly higher than those in the survival group (P<0.05). Multivariate Logistic regression analysis showed that NLR, RDW, PCT was influencing of prognosis in older patients with CAP (OR> 1, P<0.05). Conclusion: NLR, RDW and PCT are correlated with CURB-65 score, which are influencing factors for the prognosis of elderly patients with CAP. NLR, RDW and PCT have certain evaluation value for the severity and prognosis of elderly patients with CAP. |
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