| 康 梅,史万英,张 斌,吕晓培,宋 巧.血栓通胶囊辅助治疗进展性脑梗死的疗效及对患者神经功能、血液流变学和血清炎性因子的影响[J].现代生物医学进展英文版,2021,(21):4167-4170. |
| 血栓通胶囊辅助治疗进展性脑梗死的疗效及对患者神经功能、血液流变学和血清炎性因子的影响 |
| Effect of Xueshuantong Capsule in the Treatment of Progressive Cerebral Infarction and Its Influence on Neurological Function, Hemorheology and Serum Inflammatory Factors |
| Received:March 29, 2021 Revised:April 23, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.21.035 |
| 中文关键词: 血栓通胶囊 进展性脑梗死 疗效 神经功能 血液流变学 炎性因子 |
| 英文关键词: Xueshuantong capsule Progressive cerebral infarction Efficacy Neurological function Hemorheology Inflammatory factors |
| 基金项目:河北省医学科学研究重点课题资助项目（20171089） |
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| 中文摘要: |
| 摘要 目的：探讨血栓通胶囊辅助治疗进展性脑梗死的疗效及对患者神经功能、血液流变学和血清炎性因子的影响。方法：选择114例进展性脑梗死患者，随机分为对照组57例和观察组57例，对照组给予常规治疗，观察组在对照组的基础上联合血栓通胶囊治疗，比较两组疗效、神经功能、血液流变学、炎性因子及不良反应。结果：治疗1个月后观察组的临床总有效率较对照组高（P<0.05）。两组治疗1个月后全血黏度、血浆黏度、红细胞沉降率下降，且观察组低于对照组（P<0.05）。两组治疗1个月后白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）水平下降，且观察组低于对照组（P<0.05）。两组治疗1个月后神经功能指标S-100β蛋白（S-100β）、神经元特异性烯醇化酶（NSE）水平、神经功能缺损卒中量表（NIHSS）评分下降，且观察组低于对照组（P<0.05）。两组药物相关不良反应的发生率比较无差异（P>0.05）。结论：血栓通胶囊辅助治疗进展性脑梗死，可有效改善神经功能、血液流变学，降低机体炎性反应，可获得较好的治疗效果。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of Xueshuantong capsule in the treatment of progressive cerebral infarction and its influence on neurological function, hemorheology and serum inflammatory factors. Methods: 114 patients with progressive cerebral infarction were selected. They were randomly divided into control group with 57 cases and observation group with 57 cases. The control group was given conventional treatment, and the observation group was treated with Xueshuantong capsule on the basis of the control group. The efficacy, neurological function, hemorheology, inflammatory factors and adverse reactions of the two groups were compared. Results: 1 month after treatment, the total effective rate in the observation group was higher than the control group (P<0.05). The whole blood viscosity, plasma viscosity and erythrocyte sedimentation rate decreased in the two groups at 1 month after treatment, and the observation group was lower than the control group (P<0.05). 1 month after treatment, the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) in the two groups decreased, and observation group was lower than control group (P<0.05). 1 month after treatment, the neurological function indexes of S-100 β protein (S-100 β), neuron specific enolase (NSE) and neurological deficit Stroke Scale (NIHSS) decreased in the two groups, and observation group was lower than control group(P<0.05). There was no difference in the incidence of drug-related adverse reactions between the two groups(P>0.05). Conclusion: Xueshuantong capsule in the treatment of progressive cerebral infarction can effectively improve neurological function, hemorheology, reduce the inflammatory reaction of the body, which can obtain good therapeutic effect. |
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