| 肖 田,余运运,曹匡纬,何瑞靖,丁 锋.经脐单孔腹腔镜疝囊高位结扎术治疗腹股沟斜疝患儿的疗效及对血清炎性指标和免疫功能的影响[J].现代生物医学进展英文版,2021,(21):4142-4146. |
| 经脐单孔腹腔镜疝囊高位结扎术治疗腹股沟斜疝患儿的疗效及对血清炎性指标和免疫功能的影响 |
| Efficacy of Transumbilical Single Port Laparoscopic High Ligation of Hernia sac in the Treatment of Children with Indirect Inguinal Hernia and Its Influence on Serum Inflammatory Indexes and Immune Function |
| Received:March 21, 2021 Revised:April 18, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.21.030 |
| 中文关键词: 经脐单孔腹腔镜疝囊高位结扎术 腹股沟斜疝 疗效 炎性指标 免疫功能 |
| 英文关键词: Transumbilical single port laparoscopic high ligation of hernia sac Indirect inguinal hernia Curative effect Inflammatory index Immune function |
| 基金项目:湖北省自然科学基金项目（2015CFB660） |
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| 中文摘要: |
| 摘要 目的：观察经脐单孔腹腔镜疝囊高位结扎术治疗腹股沟斜疝患儿的疗效及对血清炎性指标和免疫功能的影响。方法：研究为回顾性研究，选取2018年1月~2020年12月期间在我院接受治疗的198例腹股沟斜疝患儿的临床资料，按照手术方式的差异分为传统组（97例）和微创组（101例）。传统组接受开放性腹股沟斜疝疝囊高位结扎术，微创组接受经脐单孔腹腔镜疝囊高位结扎术，观察两组手术相关指标、血清炎性指标和免疫功能变化情况，记录随访期间并发症发生率并作组间对比。结果：与传统组相比，微创组切口总长度更短，手术时间、住院时间缩短，术中出血量减少（P<0.05）。术后2 d组间对比，微创组免疫球蛋白M（IgM）、免疫球蛋白A（Ig A）、免疫球蛋白G（IgG）水平均高于传统组（P<0.05）。术后2 d组间对比，微创组血清白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、白细胞计数均低于传统组（P<0.05）。与传统组相比，微创组随访期间并发症发生率更低（P<0.05）。结论：经脐单孔腹腔镜疝囊高位结扎术治疗腹股沟斜疝患儿，具有创伤小、手术时间短、并发症少、术后恢复快等优势，且该术式引起的炎症反应及免疫抑制程度均较传统治疗更轻，是治疗此类患儿的良好选择。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the efficacy of transumbilical single port laparoscopic high ligation of hernia sac in the treatment of children with indirect inguinal hernia and its effect on serum inflammatory indexes and immune function. Methods: The study was a retrospective study, the clinical data of 198 children with indirect inguinal hernia who were treated in our hospital from January 2018 to December 2020 were selected, and they were divided into traditional group (97 cases) and minimally invasive group (101 cases) according to the difference of operation methods. The traditional group received open indirect inguinal hernia sac high ligation, and the minimally invasive group received transumbilical single port laparoscopic hernia sac high ligation. The operation indexes, serum inflammatory indexes and immune function changes of the two groups were observed, and the incidence of complications during the follow-up period was recorded and compared between the two groups. Results: Compared with the traditional group, the minimally invasive group had shorter total incision length, shorter operation time and hospital stay, and less intraoperative blood loss (P<0.05). 2 d after operation comparison between groups, the levels of immunoglobulin M (IgM), immunoglobulin A (Ig A), immunoglobulin G (IgG) in the minimally invasive group were higher than those in the traditional group(P<0.05). 2 d after operation comparison between groups, the levels of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and white blood cell count in the minimally invasive group were lower than those in the traditional group(P<0.05). Compared with the traditional group, the incidence of complications in the minimally invasive group was lower during the follow-up period(P<0.05). Conclusion: Transumbilical single port laparoscopic high ligation of hernia sac in the treatment of children with indirect inguinal hernia has the advantages of small trauma, short operation time, less complications, fast postoperative recovery, and the degree of inflammatory reaction and immunosuppression caused by this operation is lighter than traditional treatment, which is a good choice for the treatment of such children. |
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