| 哈 斯,莎其尔,于立鹏,邹艳慧,乌达木.老年心力衰竭患者BNP、LVEDD、LVEF水平与心脏功能的关系[J].现代生物医学进展英文版,2021,(21):4113-4117. |
| 老年心力衰竭患者BNP、LVEDD、LVEF水平与心脏功能的关系 |
| The Relationship between BNP, LVEDD, LVEF levels and Cardiac Function in Elderly Patients with Heart Failure |
| Received:February 22, 2021 Revised:March 18, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.21.024 |
| 中文关键词: 老年 心力衰竭 BNP LVEDD LVEF 心脏功能 |
| 英文关键词: Old age Heart failure BNP LVEDD LVEF Heart function |
| 基金项目:国家重点科技研发计划项目（2018YFC2002004） |
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| 中文摘要: |
| 摘要 目的：探究老年心力衰竭患者的脑利钠肽（Brain natriuretic peptide，BNP）、左室舒张末径（Left ventricular end diastolic diameter，LVEDD）、左室射血分数（Left ventricular ejection fraction，LVEF）水平与心脏功能的关系。方法：选择2019年3月-2020年12月于我院接受治疗的150例老年心力衰竭患者，按照其BNP水平将其分为A（BNP水平<94 pg/mL，43例）、B（BNP水平94~349.9 pg/mL，40例）、C（BNP水平350~988.9 pg/mL，44例）、D（BNP水平≥989 pg/mL，23例）4组，对比4组患者LVEDD、LVEF水平、血同型半胱氨酸（Homocysteine，HCY）水平，对比4组患者不同心功能分级比率，对比4组患者随访2个月心脏不良事件发生率，最后分析BNP、LVEDD和LVEF与心力衰竭患者心功能分级相关性。结果：A、B、C、D四组患者LVEDD、HCY呈递增趋势，LVEF呈递减趋势，C、D两组患者的LVEDD、HCY水平明显高于A、B两组（P<0.05），C、D两组LVEF水平明显低于A、B两组患者（P<0.05）；A、B、C、D四组患者心功能分级逐渐加重，A组患者I级70例，II级27例，B组患者II级60例，III级29例，C组III级68例，IV级20例，D组III级3例，IV级43例，各组间对比心功能分级差异具有统计学意义（P<0.05）；A、B、C、D四组患者心脏不良事件发生率分别为4.12 %、11.24 %、26.14 %，43.48 %，不良事件发生率逐渐升高，差异具有统计学意义（P＜0.05）；BNP、LVEDD与心功能分级呈正相关（r=0.878、0.564，P<0.05），LVEF与心功能分级呈负相关（r=0.781，P<0.05）。结论：BNP、LVEDD与LVEF指标可以作为心力衰竭评估指标，能够对心力衰竭患者心脏功能及预后进行评估。 |
| 英文摘要: |
| ABSTRACT Objective: To explore BNP, LVEDD, and LVEF levels in elderly patients with heart failure Relationship with heart function. Methods: Select 150 elderly heart failure patients who were treated in our hospital from March 2019 to December 2020 as the research objects, and divided them into A according to their BNP level (BNP level <94 pg/mL, 43 cases), B (BNP level 94~349.9 pg/mL, 40 cases), C (BNP level 350~988.9 pg/mL, 44 cases), D (BNP level ≥989 pg/mL, 23 cases) 4 groups, Compare 4 groups of patients with LVEDD, LVEF levels, blood homocysteine(Homocysteine, HCY) levels, compare 4 groups of patients with different cardiac function classification ratios, compare the incidence of adverse cardiac events in 4 groups of patients followed up for 2 months, and finally analyze BNP, LVEDD and LVEF are correlated with the heart function classification of patients with heart failure. Results: LVEDD and HCY of the four groups A, B, C, and D showed an increasing trend, while the LVEF showed a decreasing trend. The levels of LVEDD and HCY were significantly higher than those in groups A and B(P<0.05). The levels of LVEF in groups C and D were significantly lower than those in groups A and B(P<0.05); patients in groups A, B, C, and D Cardiac function classification gradually worsened, 70 patients in group A were grade I, 27 patients were in grade II, 60 patients in group B were grade II, 29 patients were in grade III, 68 patients in group C were grade III, 20 patients were in grade IV, and 3 patients in group D were grade III. 43 cases of grade IV, the difference in cardiac function classification between the groups was statistically significant (P<0.05); the incidence of adverse cardiac events in the four groups of patients A, B, C, and D were 4.12 %, 11.24 %, 26.14 % and 43.48 %, respectively. The incidence of adverse events gradually increased, and the difference was statistically significant (P<0.05); BNP, LVEDD and cardiac function classification were positively correlated (r=0.878, 0.564, P<0.05), LVEF and cardiac function classification were negative correlation (r=-0.781, P<0.05). Conclusion: BNP, LVEDD and LVEF can be used as heart failure assessment indicators, which can evaluate the heart function and prognosis of patients with heart failure. |
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