| 张启福,马永红,王 涛,胡一博,张鹤令,宗群川,马学忠.不同时间行筋膜切开术对高海拔地区挤压综合征家兔模型的心、肾功能的影响[J].现代生物医学进展英文版,2021,(20):3850-3855. |
| 不同时间行筋膜切开术对高海拔地区挤压综合征家兔模型的心、肾功能的影响 |
| Effects of Fasciotomy at Different Time on Cardiac and Renal Function in Rabbits with Crush Syndrome at High Altitude |
| Received:April 26, 2021 Revised:May 21, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.20.010 |
| 中文关键词: 筋膜切开 挤压 高海拔 家兔模型 |
| 英文关键词: Fasciotomy Extrusion High altitude Rabbit model |
| 基金项目:青海省科技计划项目（2019-SF-136）；青海大学附属医院中青年科研基金项目（ASRF-2014-10） |
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| 中文摘要: |
| 摘要 目的：本研究旨在针对高海拔地区低压低氧的特殊性，探讨分析筋膜切开对高海拔挤压伤家兔模型的主要脏器影响，为在高海拔地区进一步研究挤压伤的救治打下基础并提供临床参考依据。方法：选取实验地与饲养地均为高海拔地区西宁的健康成年新西兰家兔，共70 只。随机分为筋膜切开实验组（即A组60只）、对照组（即B组10 只未筋膜切开），4小时后同时解压两组，根据解压后行筋膜切开的时间将A组再分为6组（每组10只)，分别定为Ⅰ组（0 h）、Ⅱ组（2 h）、Ⅲ组（4 h）、Ⅳ组（6 h）、Ⅴ组（8 h）、Ⅵ组（10 h）；分别检测Ⅰ-Ⅵ组及B组的的静脉血肌酐 Cr、尿素氮 BUN、血钾 K+、乳酸脱氢酶LDH、α-羟丁酸脱氢酶HBDH等生化指标；24 小时后取挤压综合征家兔模型的心肌、肾脏及挤压处的肌肉做病理切片并镜下观察分析；采用SPSS19.0统计软件进行数据分析，以P<0.05为差异有统计学意义。结果：A组、B组挤压4 h后血BUN、Cr、K+、LDH、HBDH差异无统计学意义(P>0.05)，两组资料具有可比性。Ⅰ-Ⅵ组与B组的的静脉血BUN、Cr、K+、LDH、HBDH等生化指标组间差异均无统计学意义(P>0.05)，各亚组之间在相同时间点生化指标也无统计学差异(P>0.05)。结论：筋膜切开对高海拔挤压综合征家兔模型主要脏器早期恢复中影响不明显。 |
| 英文摘要: |
| ABSTRACT Objective: The purpose of this study is to analyze the effect of fasciotomy on the model of high altitude extrusion rabbits, and to provide clinical basis for the treatment of extrusion injury in high altitude areas. Methods: A total of 70 healthy adult New Zealand rabbits were selected from both the experimental site and the breeding site in high altitude area Xining. Randomly divided into the experimental group of fasciotomy (60 in group A) and the control group (10 in group B without fasciotomy). After 4 hours, the two groups were decompressed at the same time. According to the time of fasciotomy after decompression, Divide group A into 6 groups (10 animals in each group), and set them as group Ⅰ (0 h), group Ⅱ (2 h), group Ⅲ (4 h), group Ⅳ (6 h), group Ⅴ (8 h), group Ⅵ (10 h); Detect biochemical indicators such as venous blood creatinine Cr, urea nitrogen BUN, blood potassium K+, lactate dehydrogenase LDH, α-hydroxybutyrate dehydrogenase HBDH in groups I-VI and B respectively; Twenty-four hours later, the myocardium, kidney and muscle of the crush syndrome rabbit model were taken for pathological section and observed under microscope 24 hours later; use SPSS19.0 statistical software for data analysis, with P<0.05 as the difference is statistically significant. Results: There was no statistically significant difference in blood BUN, Cr, K+, LDH, HBDH between group A and group B after 4 hours of squeezing(P>0.05). The data of the two groups were comparable. There was no significant difference in venous blood BUN, Cr, K+, LDH, HBDH and other biochemical indexes between group Ⅰ-Ⅵ and group B(P>0.05), and there was no statistical difference in the biochemical indicators between the subgroups at the same time point(P>0.05). Conclusion: Fasciotomy has no obvious effect on the early recovery of main organs in rabbit models with high altitude crush syndrome. |
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