| 刘 欣,贾 琦,周 莹,戴 民,王 舒,高宇哲.初诊腋窝淋巴结阳性乳腺癌新辅助化疗后对腋窝淋巴结转阴性前哨活检的影响分析[J].现代生物医学进展英文版,2021,(19):3769-3772. |
| 初诊腋窝淋巴结阳性乳腺癌新辅助化疗后对腋窝淋巴结转阴性前哨活检的影响分析 |
| Analysis of the Influence of Sentinel Biopsy of Axillary Lymph Node to Negative Sentinel Biopsy after Neoadjuvant Chemotherapy for Newly Diagnosed Axillary Lymph Node Positive Breast cancer |
| Received:February 02, 2021 Revised:February 25, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.19.035 |
| 中文关键词: 腋窝淋巴结 乳腺癌 新辅助化疗 前哨淋巴结 |
| 英文关键词: Axillary lymph nodes Breast cancer Neoadjuvant chemotherapy Sentinel lymph nodes |
| 基金项目:贵州省科技厅基金项目（黔科合基础[2017]1114） |
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| 中文摘要: |
| 摘要 目的：探究对初诊腋窝淋巴结阳性乳腺癌行新辅助化疗患者开展腋窝前哨淋巴结活检的临床意义。方法：选择2017年1月至2020年10月于我院接受改良根治术或保乳术治疗的100例初诊腋窝淋巴结阳性乳腺癌患者，将其中50例病理检测II B、III期行4~8个疗程新辅助化疗后实施前哨淋巴结活检患者设为研究组，将50例I、II A期直接行前哨淋巴结活检患者设为对照组，对比两组患者前哨淋巴结检出率、准确率、假阴性率和灵敏度，同时就患者病理特征与前哨淋巴结检出率的相关性开展分析。结果：（1）比较显示研究组患者与对照组患者在前哨淋巴结检出数、前哨淋巴结检出率以及前哨淋巴结假阴性率方面组间差异不大（P>0.05）；（2）病理学特征分析显示肿瘤直径以及临床N分期同新辅助化疗后患者前哨淋巴结检出阳性率密切相关（P<0.05）。结论：对初诊腋窝淋巴结阳性行新辅助化疗乳腺癌患者实施前哨淋巴结活检具有较显示的临床意义，能够较好的预测患者腋窝淋巴结状况，同时化疗前肿瘤直径、临床N分期是影响前哨淋巴结检出率的重要影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical significance of axillary sentinel lymph node biopsy in newly diagnosed axillary lymph node positive breast cancer patients undergoing neoadjuvant chemotherapy. Methods: From January 2017 to October 2020, 100 newly diagnosed breast cancer patients with axillary lymph node positive were selected as the research objects, and 50 patients who underwent sentinel lymph node biopsy after undergoing 4~8 courses of neoadjuvant chemotherapy in stage II B and stage III were set as the research group, and 50 patients who underwent sentinel lymph node biopsy directly in stage I and II A were set as the control group. The detection rate, accuracy and false negative of sentinel lymph nodes were compared between the two groups. Results: (1) The comparison showed that there was no significant difference between the study group and the control group in the number, rate and false negative rate of sentinel lymph nodes (P>0.05). (2) Pathological analysis showed that tumor diameter and clinical N stage were closely related to the positive rate of sentinel lymph nodes after neoadjuvant chemotherapy (P<0.05). Conclusion: Sentinel lymph node biopsy for breast cancer patients with newly diagnosed axillary lymph node positive undergoing neoadjuvant chemotherapy has obvious clinical significance, which can better predict the axillary lymph node status of patients. At the same time, tumor diameter before chemotherapy, clinical N stage and BMI of patients are important factors affecting the detection rate of sentinel lymph nodes. |
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