| 杨 辉,孙 伟,赵世杰,徐晓宁,沈存芳.生肌玉红膏联合康复新液治疗乳腺癌根治术后皮瓣坏死创面不愈的临床效果[J].现代生物医学进展英文版,2021,(19):3752-3755. |
| 生肌玉红膏联合康复新液治疗乳腺癌根治术后皮瓣坏死创面不愈的临床效果 |
| Clinical Effect of Shengjiyuhong Ointment Combined with Kangfuxin Liquid in Treating Non-healing Wounds of Skin Flap Necrosis after Radical Mastectomy |
| Received:April 05, 2021 Revised:April 22, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.19.031 |
| 中文关键词: 生肌玉红膏 康复新液 皮瓣坏死创面不愈 乳腺癌根治术 |
| 英文关键词: Shengji Yuhong Ointment Kangfuxin Liquid Unhealed Skin Flap Necrosis Radical Mastectomy |
| 基金项目:国家自然科学基金项目（81460428） |
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| 中文摘要: |
| 摘要 目的：研究生肌玉红膏联合康复新液对于乳腺癌根治术后皮瓣坏死创面不愈的临床效果。方法：选择2016年1月～2020年12月我院在乳腺癌根治术后发生皮瓣坏死创面不愈的80例患者，将其随机分为两组。对照组单用康复新液，观察组联用生肌玉红膏。比较两组的创面改善时间，检测两组的血清肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）、血管内皮生长因子（VEGF）和白介素-8（IL-8）水平，且记录两组的创面面积及VAS疼痛评分。结果：观察组的腐肉脱落时间、新生上皮出现时间、引流管拔出时间、创面愈合时间、住院时间和上肢康复活动时间均较对照组显著缩短(P<0.05)；治疗后，两组的血清IL-6、TNF-α和IL-8水平、创面面积以及VAS疼痛评分均较治疗前显著降低，VEGF水平则显著升高(P<0.05)，且观察组的以上指标均较对照组显著改善(P<0.05)。结论：生肌玉红膏联合康复新液对于乳腺癌根治术后皮瓣坏死创面不愈有显著的效果，可通过改善患者血清炎症反应水平，从而进一步减轻患者创面疼痛并促进愈合。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Shengjiyuhong ointment combined with Kangfuxin liquid in treating non-healing wounds of skin flap necrosis after radical mastectomy. Methods: Selected 80 cases of patients with non-healing wounds of skin flap necrosis after radical mastectomy from January 2016 to December 2020, divided into two groups randomly. The control group was treated with Kangfuxin liquid alone, and the observation group was treated with Shengjiyuhong ointment. Compared with the wound surface improvement time of the two groups, the serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) levels were detected and recorded The wound area and VAS pain score of the two groups. Results: The time of carrion shedding, the appearance of new epithelium, the time of draining the drainage tube, the time of wound healing, the time of hospitalization and the time of upper limb rehabilitation activities in the observation group were significantly shorter than those in the control group (P<0.05); After treatment, the levels of serum IL-6, TNF-α and IL-8, wound area and VAS pain score of the two groups were significantly lower than before treatment, while the VEGF level was significantly increased (P<0.05). And the above indicators of the observation group were significantly improved compared with the control group (P<0.05). Conclusion: Shengjiyuhong ointment combined with Kangfuxin liquid has a significant effect on the non-healing of skin flap necrosis wound after radical mastectomy. It can improve the serum inflammatory reaction level of the patient, thereby further reducing the pain of the patient's wound and promoting healing. |
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