| 钟士杰,邓 堂,林开文,廖 勇,魏胜超,李 奇,徐双琴,云宏芳,金桂云.缺氧性肺动脉高压的治疗进展[J].现代生物医学进展英文版,2021,(18):3596-3600. |
| 缺氧性肺动脉高压的治疗进展 |
| Progress in Treatment of Hypoxic Pulmonary Hypertension |
| Received:January 03, 2021 Revised:January 26, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.18.043 |
| 中文关键词: 缺氧性肺动脉高压 HPH 治疗 机制 |
| 英文关键词: Hypoxic pulmonary hypertension HPH Treatment Mechanism |
| 基金项目:国家自然科学基金项目（31560267） |
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| 中文摘要: |
| 摘要：缺氧性肺动脉高压（HPH）是指由于长期缺氧导致血管内皮细胞损伤，血管活性因子水平失调，以血管收缩及血管重塑为主要病理表现的一类肺动脉高压症（PAH），HPH发病率高，死亡率高，除了肺移植，目前尚无根治办法，对于HPH的治疗一直是研究热点，本文将结合近年国内外最新研究从基因靶向、离子通道、线粒体、NO相关药物、西药、中药领域对HPH的治疗做一概述。 |
| 英文摘要: |
| ABSTRACT: Hypoxic pulmonary hypertension (HPH) refers to a type of pulmonary arterial hypertension (PAH) with vasoconstriction and vascular remodeling as the main pathological manifestations of vascular endothelial cell damage caused by long-term hypoxia, the incidence of HPH High mortality rate. Except for lung transplantation, there is currently no cure. The treatment of HPH has always been a research hotspot. This article will combine the latest research at home and abroad in recent years from gene targeting, ion channels, mitochondria, NO-related drugs, western medicine, and traditional Chinese medicine. The field gives an overview of the treatment of HPH. |
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