| 张铃铛,张 鹏,赵 锐,刘明东,宋 毅,汪 峰.不同时机行血管介入栓塞术治疗颅内动脉瘤的疗效及对患者预后、神经功能和血清炎性因子的影响[J].现代生物医学进展英文版,2021,(18):3564-3568. |
| 不同时机行血管介入栓塞术治疗颅内动脉瘤的疗效及对患者预后、神经功能和血清炎性因子的影响 |
| Efficacy of Endovascular Interventional Embolization on Intracranial Aneurysms at Different Times and Its Effect on Prognosis, Neurological Function and Serum Inflammatory Factors |
| Received:March 01, 2021 Revised:March 24, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.18.036 |
| 中文关键词: 不同时机 血管介入栓塞术 颅内动脉瘤 疗效 预后 神经功能 炎性因子 |
| 英文关键词: Different times Endovascular interventional embolization Intracranial aneurysm Efficacy Prognosis Neurological function Inflammatory factors |
| 基金项目:重庆市自然科学基金项目（cstc2019jcyj-zdxmX003） |
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| 中文摘要: |
| 摘要 目的：探讨不同时机行血管介入栓塞术治疗颅内动脉瘤的疗效及对患者预后、神经功能和血清炎性因子的影响。方法：选择2019年3月到2020年12月期间我院收治的80例颅内动脉瘤患者，按手术时间的不同将其分为早期组、延期组，其中早期组36例，发病至手术时间≤72 h；延期组44例，发病至手术时间＞72 h，对比两组疗效、预后、神经功能、血清炎性因子及并发症发生率。结果：早期组的完全栓塞率高于延期组，基本栓塞率低于延期组（P<0.05）。两组术后3个月美国国立卫生研究院卒中量表（NIHSS）、改良Rankin量表评分均较术前下降，且早期组低于延期组（P<0.05）。早期组的预后良好率高于延期组（P<0.05）。两组术后3 d血清白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平下降，且早期组低于延期组（P<0.05），白介素-10（IL-10）水平升高，且早期组高于延期组（P<0.05）。早期组的并发症发生率低于延期组（P<0.05）。结论：早期行血管介入栓塞术治疗颅内动脉瘤患者，可提高完全栓塞率，减轻神经功能损伤及炎性应激，降低并发症的发生风险，促进预后和生活质量改善。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of endovascular interventional embolization on intracranial aneurysms at different times and its influence on prognosis, neurological function and serum inflammatory factors. Methods: 80 patients with intracranial aneurysms who were admitted to our hospital from March 2019 to December 2020 were selected. According to the different operation time, the patients were divided into early group and delayed group, among early group had 36 cases, with the time from onset to operation ≤72 h. Delayed group had 44 cases, the time from onset to operation＞72 h. The efficacy, prognosis, neurological function, inflammatory factors and the incidence rate of complications were compared between the two groups. Results: The complete embolization rate of the early group was higher than that of the delayed group, and the basic embolization rate was lower than that of the delayed group (P<0.05). The scores of National Institutes of Health Stroke Scale (NIHSS) and modified Rankin scale at 3 months after operation in the two groups were lower than those before operation, and the scores in the early group were lower than those in the delayed group (P<0.05). The good prognosis rate of the early group was higher than that of the delayed group (P<0.05). The levels of interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) in two groups decreased at 3d after operation, and the early group was lower than the delay group (P<0.05), and the level of interleukin-10(IL-10) increased, and the early group was higher than the delayed group (P<0.05). The incidence rate of complications in the early group was lower than that in the delayed group (P<0.05). Conclusion: Early endovascular interventional embolization for intracranial aneurysms can improve the complete embolization degree, reduce neurological and inflammation damage, reduce the risk of complications, and improve the prognosis and quality of life. |
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