| 王小丽,孙国强,吕玉霞,龙青云,张 冲.马来酸麦角新碱联合米索前列醇对剖宫产产后出血患者凝血功能、血流动力学及血清NO、NOS水平的影响[J].现代生物医学进展英文版,2021,(18):3546-3549. |
| 马来酸麦角新碱联合米索前列醇对剖宫产产后出血患者凝血功能、血流动力学及血清NO、NOS水平的影响 |
| Effect of Ergometrine Maleate Combined with Misoprostol on Coagulation Function, Hemodynamics and Serum NO, NOS Levels in Patients with Postpartum Hemorrhage after Cesarean Section |
| Received:December 05, 2020 Revised:December 27, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.18.032 |
| 中文关键词: 马来酸麦角新碱 米索前列醇 剖宫产 产后出血 凝血功能 血流动力学 一氧化氮 一氧化氮合酶 |
| 英文关键词: Ergometrine maleate Misoprostol Cesarean section Postpartum hemorrhage Coagulation function Hemodynamics Nitric oxide Nitric oxide synthase |
| 基金项目:湖北省自然科学基金项目(2013CFC023) |
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| 中文摘要: |
| 摘要 目的：探讨马来酸麦角新碱联合米索前列醇对剖宫产产后出血患者凝血功能、血流动力学及血清一氧化氮（NO）、一氧化氮合酶（NOS）水平的影响。方法：选取2017年6月~2019年10月期间我院收治的剖宫产产后出血患者98例，根据信封抽签法分为对照组（n=49）和研究组（n=49），对照组患者给予米索前列醇，研究组在对照组基础上联合马来酸麦角新碱治疗，比较两组患者凝血功能、血流动力学、临床指标、血清NO、NOS水平及不良反应。结果：研究组治疗后的产后恶露持续时间、住院时间短于对照组，产后2 h内出血、产后2～24 h出血少于对照组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。两组治疗后凝血酶原时间（PT）、凝血活酶时间（APTT），纤维蛋白原（FIB）、D-二聚体（D-D）水平均下降，且研究组低于对照组（P<0.05）。两组治疗后收缩压（SBP）、舒张压（DBP）均下降，但研究组高于对照组（P<0.05），两组治疗后心率（HR）升高，但研究组低于对照组（P<0.05）。两组治疗后血清NO、NOS水平均下降，且研究组低于对照组（P<0.05）。结论：剖宫产产后出血患者给予马来酸麦角新碱联合米索前列醇治疗，可有效维持血流动力学平稳，降低血清NO、NOS水平，改善患者凝血功能及临床指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of ergometrine maleate combined with misoprostol on coagulation function, hemodynamics and serum nitric oxide (NO) and nitric oxide synthase (NOS) levels in patients with postpartum hemorrhage after cesarean section. Methods: 98 patients with postpartum hemorrhage after cesarean section who were treated in our hospital from June 2017 to October 2019 were selected, they were divided into control group (n=49) and study group (n=49) according to envelope drawing method. Patients in control group were given misoprostol, and study group were treated with ergonoxine maleate on the basis of control group. Coagulation function, hemodynamics, clinical indicators, serum NO, NOS levels and adverse reactions were compared between the two groups. Results: The duration of lochia postpartum and hospitalization time in the study group were shorter than those in the control group, and the bleeding within 2 h after delivery and 2~24 h after delivery in the study group were less than those in the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups(P>0.05). After treatment, prothrombin time (PT), thromboplastin time (APTT), fibrinogen (FIB), D-Dimer (D-D) levels of the two groups decreased, and the study group was lower than those of the control group(P<0.05). Systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the two groups decreased after treatment, but the study group was higher than that of the control group(P<0.05), and the heart rate (HR) of the two groups increased after treatment, but the study group was lower than that of the control group(P<0.05). After treatment, serum NO and NOS levels in both groups were decreased, and the study group was lower than the control group(P<0.05). Conclusion: Ergometrine maleate combined with misoprostol in the treatment of postpartum hemorrhage after cesarean section can effectively maintain the hemodynamic stability, reduce the level of serum NO and NOS, and improve the coagulation function and clinical indicators. |
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