| 姜 丽,程 宇,罗 茜,洪 梅,邓晶荣.急性肾损伤的危险因素及尿液spd-1、IL-18、Cys-C的预测价值分析[J].现代生物医学进展英文版,2021,(18):3542-3545. |
| 急性肾损伤的危险因素及尿液spd-1、IL-18、Cys-C的预测价值分析 |
| Risk Factors of Acute Renal Injury and Predictive Value of Urine Spd-1, IL-18 and Cys-C |
| Received:November 23, 2020 Revised:December 18, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.18.031 |
| 中文关键词: 胱抑素C 可溶性程序性死亡受体1 白细胞介素18 急性肾损伤 影响因素 预测价值 |
| 英文关键词: Cystatin C Soluble programmed death receptor-1 Interleukin-18 Acute renal injury Influencing factor Predictive value |
| 基金项目:重庆市卫生和计划生育委员会科研资助项目(2016MSXM090) |
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| 中文摘要: |
| 摘要 目的：探讨急性肾损伤的危险因素及尿液可溶性程序性死亡受体1（spd-1）、白细胞介素18（IL-18）及胱抑素C（Cys-C）对急性肾损伤的预测价值。方法：选择2018年10月至2019年10月于我院就诊的急性肾损伤患者120例作为观察组，同时选取肾功能正常患者118例作为对照组，收集两组患者的临床资料，检测尿液spd-1、IL-18、Cys-C的含量，采用Logistic回归分析急性肾损伤的危险因素，并绘制ROC曲线，评估尿液spd-1、IL-18、Cys-C对急性肾损伤的预测价值。结果：观察组血清尿素氮(BUN)明显高于对照组（P<0.05）。观察组尿液spd-1、IL-18、Cys-C明显高于对照组（P<0.05）。Logistic回归分析结果显示，尿液spd-1（OR=1.461，P=0.000）、IL-18（OR=1.742，P=0.003）、Cys-C（OR=1.241，P=0.002）是急性肾损伤的危险因素。尿液spd-1预测急性肾损伤曲线下面积（AUC）为0.660，特异度为0.640，灵敏度为0.646；IL-18预测急性肾损伤的AUC为0.672，特异度为0.669，灵敏度为0.675；Cys-C预测急性肾损伤的AUC为0.643，特异度为0.649，灵敏度为0.673；三者联合检测预测急性肾损伤的AUC为0.792，特异度为0.667，灵敏度为0.917。结论：spd-1、IL-18、Cys-C在急性肾损伤患者尿液中含量明显增加，尿液spd-1、IL-18、Cys-C增加是急性肾损伤的危险因素，且三者联合检测对急性肾损伤的预测价值较高，具有一定的临床意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the risk factors of acute renal injury and the predictive value of urine soluble programmed death receptor-1 (spd-1), interleukin-18 (IL-18) and cystatin C (Cys-C) in acute renal injury. Methods: 120 patients with acute renal injury treated in our hospital from October 2018 to October 2019 were selected as the observation group, 118 patients with normal renal function were selected as the control group meanwhile. The clinical datas of the two groups were collected, the contents of urine spd-1, IL-18 and Cys-C were measured, the risk factors of acute renal injury were analyzed by Logistic regression analysis and ROC curve was drawn, the predictive value of urine spd-1, IL-18 and Cys-C for acute renal injury were evaluated. Results: Serum urea nitrogen (BUN) in the observation group was significantly higher than that in the control group(P<0.05). Urine spd-1, IL-18 and Cys-C in the observation group were significantly higher than those in the control group (P<0.05). Logistic regression analysis showed that urine spd-1 (OR=1.461, P=0.000), IL-18 (OR=1.742, P=0.003) and Cys-C (OR=1.241, P=0.002) were risk factors for acute kidney injury. Urine spd-1 prediction of acute kidney injury area under the curve（AUC） was 0.660, specificity was 0.640, the sensitivity was 0.646. IL-18 prediction of acute kidney injury, AUC was 0.672, specificity was 0.669, the sensitivity was 0.675. Cys-C prediction of acute kidney injury AUC was 0.643, specificity was 0.649, the sensitivity was 0.673. To combined detection of three predicting the AUC of acute kidney injury was 0.792, specificity was 0.667, the sensitivity was 0.917. Conclusion: The contents of urine spd-1, IL-18, and Cys-C are significantly increased in patients with acute kidney injury and increased urine spd-1, IL-18, Cys-C are risk factors for acute kidney injury, combined detection of three has a high predictive value for acute kidney injury, with certain clinical significance. |
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