| 吴振旺,崔红宙,朱冠能,孙 刚,吴文辉.醒脑静联合纳洛酮对急性脑出血伴意识障碍患者神经功能、炎性因子和氧化应激的影响[J].现代生物医学进展英文版,2021,(18):3538-3541. |
| 醒脑静联合纳洛酮对急性脑出血伴意识障碍患者神经功能、炎性因子和氧化应激的影响 |
| Effects of Xingnaojing Combined with Naloxone on Nervous Function, Inflammatory Factors and Oxidative Stress in Patients with Acute Cerebral Hemorrhage and Disturbance of Consciousness |
| Received:February 27, 2021 Revised:March 22, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.18.030 |
| 中文关键词: 醒脑静 纳洛酮 急性脑出血 意识障碍 神经功能 炎性因子 氧化应激 |
| 英文关键词: Xingnaojing Naloxone Acute cerebral hemorrhage Disturbance of consciousness Neurological function Inflammatory factors Oxidative stress |
| 基金项目:国家自然科学基金项目（81172544） |
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| 中文摘要: |
| 摘要 目的：探讨纳洛酮联合醒脑静对急性脑出血（ACH）伴意识障碍患者炎性因子、神经功能和氧化应激的影响。方法：选取2017年2月~2019年12月期间我院收治的95例ACH伴意识障碍患者，按照随机数字表法将上述患者分为对照组（n=47）和研究组（n=48），对照组患者予以纳洛酮治疗，研究组则在对照组的基础上联合醒脑静治疗，比较两组患者疗效、神经功能、炎性因子和氧化应激指标，记录两组不良反应发生情况。结果：研究组治疗10 d后的临床总有效率为91.67%（44/48），高于对照组的74.47%（35/47）（P<0.05）。两组治疗10 d后美国国立卫生研究院卒中量表（NIHSS）评分，白介素-6（IL-6）、C反应蛋白（CRP）以及肿瘤坏死因子-α（TNF-α）、丙二醛（MDA）水平均较治疗前下降，且研究组低于对照组（P<0.05）。两组治疗10 d后超氧歧化酶 (SOD)水平均较治疗前升高，且研究组高于对照组（P<0.05）。两组不良反应发生率对比未见统计学差异（P>0.05）。结论：醒脑静联合纳洛酮治疗ACH伴意识障碍患者，疗效显著，可有效改善患者神经功能、炎性因子和氧化应激，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Xingnaojing combined with naloxone on inflammatory factors, nervous function and oxidative stress in patients with acute cerebral hemorrhage (ACH) and disturbance of consciousness. Methods: 95 cases of patients with ACH and disturbance of consciousness who were admitted to our hospital from February 2017 to December 2019 were selected, patients were divided into control group (n=47) and study group (n=48) according to the method of random number table. The control group was treated with naloxone, while the study group was treated with Xingnaojing on the basis of the control group. The curative effect, neurological function, inflammatory factors and oxidative stress of the two groups were compared, and the adverse reaction of the two groups were recorded. Results: The total clinical effective rate of the study group at 10 d after treatment was 91.67% (44 / 48), which was higher than 74.47% (35/47) of the control group (P<0.05). 10 d after treatment, the national institutes of health stroke scale (NIHSS) score, levels of interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and malondialdehyde (MDA) in the two groups were lower than those before treatment, and the study group was lower than the control group(P<0.05). The level of superoxide dismutase (SOD) in the two groups increased at 10d after treatment, and the study group was higher than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Xingnaojing combined with naloxone is effective in the treatment of ACH patients and disturbance of consciousness. It can effectively improve the neurological function, inflammatory factors and oxidative stress, and which has a good safety. |
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