| 高 志,罗仲流,范志航,陈鹏旭,孙 敏.关节镜下不同缝合修复方法对3度半月板损伤患者手术效果、膝关节本体感觉及BGP、IGF-Ⅰ、MMP-1水平的影响[J].现代生物医学进展英文版,2021,(18):3494-3497. |
| 关节镜下不同缝合修复方法对3度半月板损伤患者手术效果、膝关节本体感觉及BGP、IGF-Ⅰ、MMP-1水平的影响 |
| Effects of Different Suture Repair Methods Under Arthroscopy on the Operative Effect, Proprioception of Knee Joint and the Levels of BGP, IGF-I and MMP-1 in Patients with Third Degree Meniscus Injury |
| Received:November 26, 2020 Revised:December 21, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.18.020 |
| 中文关键词: 关节镜下全内缝合法 关节镜下外内缝合法 3度半月板损伤 膝关节本体感觉 胰岛素样生长因子Ⅰ 骨钙素 基质金属蛋白酶1 |
| 英文关键词: Arthroscopic total internal suture Arthroscopic external internal suture Third degree meniscus injury Proprioception of knee joint Insulin-like growth factor I Osteocalcin Matrix metalloproteinase 1 |
| 基金项目:四川省干部保健基金项目（川干研2019-602） |
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| 中文摘要: |
| 摘要 目的：探讨关节镜下不同缝合修复方法对3度半月板损伤患者手术效果、膝关节本体感觉以及骨钙素（BGP），胰岛素样生长因子Ⅰ（IGF-Ⅰ）、基质金属蛋白酶1（MMP-1）水平的影响。方法：选取2018年1月-2019年10月期间我院收治的3度半月板损伤患者120例，根据随机数字表法分为A组（n=60，关节镜下外内缝合法）和B组（n=60，关节镜下全内缝合法），比较两组患者手术指标、并发症发生情况、国际膝关节评分委员会（IKDC）评分、Lysholm评分、视觉疼痛模拟量表（VAS）评分、膝关节本体感觉以及BGP、IGF-Ⅰ、MMP-1水平。结果：B组手术时间短于A组（P<0.05）；两组住院时间、术中出血量比较无差异（P>0.05）。两组术后6个月IKDC评分、Lysholm评分较术前升高，VAS评分以及BGP、IGF-Ⅰ、MMP-1水平，15°、45°、75°膝关节本体感觉差值较术前降低（P<0.05）；B组术后6个月IKDC评分、Lysholm评分高于A组，而VAS评分以及BGP、IGF-Ⅰ、MMP-1水平，15°、45°、75°膝关节本体感觉差值则低于A组（P<0.05）。两组并发症发生率比较差异未见统计学意义（P>0.05）。结论：与关节镜下外内缝合法相比，关节镜下全内缝合法可缩短手术时间，更好的改善患者膝关节功能，提高膝关节本体感觉，还能有效降低BGP、IGF-Ⅰ、MMP-1水平，安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of different suture repair methods under arthroscopy on the operative effect, proprioception of knee joint and the levels of osteocalcin (BGP), insulin-like growth factor-I (IGF-I) and matrix metalloproteinase-1 (MMP-1) in patients with third degree meniscus injury. Methods: From January 2018 to October 2019, 120 patients with third-degree meniscus injury in our hospital were selected, patients were randomly divided into the group A(n=60, arthroscopic external internal suture) and group B (n=60, arthroscopic total internal suture). The operation indicators, complications, international (IKDC) score, Lysholm knee score committee score, visual analog scale (VAS) pain scores, proprioception of knee joint and levels of BGP, IGF-Ⅰ, MMP 1 of two groups were compared. Results: The operation time of group B was shorter than that of group A(P<0.05). There were no significant differences between the two groups in intraoperative blood loss and hospital stays (P>0.05). 6 months after operation, the scores of IKDC and Lysholm in the two groups were higher than those before operation, and the VAS score and levels of BGP, IGF-I, MMP 1, 15°, 45°and 75°of knee proprioception difference were lower than those before operation(P<0.05). 6 months after operation, the scores of IKDC and Lysholm of group B were higher than those of group A, while the VAS score and levels of BGP, IGF-I, MMP 1, 15°, 45°and 75°of knee proprioception difference were lower than those of group A(P<0.05). There was no significant difference in the incidence of complications between the two groups(P>0.05). Conclusion: Compared with the arthroscopic external internal suture, the arthroscopic total internal suture can shorten the operation time, better to improve the knee joint function, improve the proprioception of the knee joint, effectively reduce the levels of BGP, IGF-I and MMP-1, which is safe and reliable. |
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