| 徐异彩,张 冉,王小颖,杨春燕,武云哲.超声E成像在非酒精性脂肪性肝病中的诊断价值研究[J].现代生物医学进展英文版,2021,(18):3482-3485. |
| 超声E成像在非酒精性脂肪性肝病中的诊断价值研究 |
| Study on the Diagnostic Value of Ultrasound E-imaging in Nonalcoholic Fatty Liver Disease |
| Received:November 24, 2020 Revised:December 20, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.18.017 |
| 中文关键词: 超声E成像 非酒精性脂肪性肝病 诊断 脂肪含量 ElastPQ |
| 英文关键词: Ultrasound E-imaging Nonalcoholic fatty liver disease Diagnostic Fat content ElastPQ |
| 基金项目:河北省医学科学研究重点计划项目(20160083)；石家庄市科学技术研究与发展计划项目（191460433） |
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| 中文摘要: |
| 摘要 目的：研究超声E成像在非酒精性脂肪性肝病中的诊断价值。方法：选取2018年1月-2020年2月我院诊断的非酒精性脂肪性肝病患者120例作为观察组，另外，选取同期健康体检的志愿者101例作为对照组，分别对两组受试者进行超声E成像、MR mDixon序列检查，比较两组受试者以及不同病情严重程度患者的谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TBIL）、碱性磷酸酶（ALP）、杨氏模量值（ElastPQ）以及脂肪含量之间的差异，分析患者的病情严重程度与ElastPQ以及脂肪含量的相关性。结果：观察组的ALT、AST、TBIL、ALP、ElastPQ以及脂肪含量显著高于对照组（P＜0.05）；不同病情严重程度患者的ALT、AST、TBIL、ALP、ElastPQ以及脂肪含量之间的差异有统计学意义（P＜0.05），ALT、AST、TBIL、ALP、ElastPQ以及脂肪含量从高到低依次为重度组、中度组以及轻度组，患者的病情严重程度与ElastPQ以及脂肪含量呈正相关（P＜0.05），ElastPQ与脂肪含量呈正相关（P＜0.05）。结论：超声E成像对于非酒精性脂肪性肝病患者肝脏组织的受损程度具有较高的诊断价值，建议临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the diagnostic value of Ultrasound E-imaging in nonalcoholic fatty liver disease. Methods: 120 patients with nonalcoholic fatty liver disease who were diagnosed from January 2018 to February 2020 were selected as the observation group. In addition, 101 patients with the same period of physical examination were selected as the control group. The two groups were examined by Ultrasound E-imaging and Mr mdixon sequence, and the differences of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), alkaline phosphatase (ALP), Young's modulus (ElastPQ) and fat content between the two groups and patients with different severity were compared. The correlation between the severity of the disease and ElastPQ and fat content were analyzed. Results: The levels of ALT, AST, TBIL, ALP, ElastPQ and fat content in the observation group were significantly higher than those in the control group(P＜0.05). The differences of ALT, AST, TBIL, ALP, ElastPQ and fat content in patients with different severity were statistically significant(P＜0.05). ALT, AST, TBIL, ALP, ElastPQ and fat content from high to low were severe group, moderate group and mild group. The severity of disease were positively correlated with ElastPQ and fat content (P＜0.05), and ElastPQ was positively correlated with fat content (P＜0.05). Conclusion: Ultrasound E-imaging has a high diagnostic value for liver tissue damage in patients with nonalcoholic fatty liver disease, which is recommended for clinical application. |
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