| 彭 博,王 菲,鲍庆红,管丽敏,吉玲玲.葛根素注射液对糖尿病大鼠牙周炎的治疗效果及血清AGEs、炎性因子表达的影响[J].现代生物医学进展英文版,2021,(18):3417-3421. |
| 葛根素注射液对糖尿病大鼠牙周炎的治疗效果及血清AGEs、炎性因子表达的影响 |
| Effect of Puerarin Injection on Periodontitis and Expression of Serum Ages and Inflammatory Factors in Diabetic Rats |
| Received:February 01, 2021 Revised:February 24, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.18.004 |
| 中文关键词: 葛根素注射液 糖尿病 牙周炎 炎性因子 晚期糖基化终末产物 |
| 英文关键词: Puerarin injection Diabetes Periodontitis Inflammatory factors Advanced glycation end products |
| 基金项目:陕西省创新人才推进计划-青年科技新星项目（2020KJXX-025） |
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| 中文摘要: |
| 摘要 目的：分析葛根素注射液对糖尿病大鼠牙周炎的治疗效果及血清晚期糖基化终末产物（advanced glycosylation end products，AGEs）、炎性因子表达的影响。方法：随机选取10只大鼠作为正常对照组，另选40只建立糖尿病牙周炎大鼠，将建模成功的大鼠随机分成模型组、实验组和阳性组，每组10只。给药处理6周后，取血清检测AGEs、白细胞介素-6（interleukin-6，IL-6）、IL-8及肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）表达情况；取牙周组织观察压槽骨丧失程度。结果：与健康对照组相比，模型组大鼠胰岛素水平显著降低，血糖、AGEs、IL-6、IL-8和TNF-α水平显著升高，压槽骨降低高度显著增大（P＜0.05）。与模型组相比，实验组和阳性组大鼠水平显著升高，血糖、AGEs、IL-6、IL-8和TNF-α水平显著降低，压槽骨降低高度升高减小（P＜0.05）。结论：葛根素注射液可通过促进胰岛素表达，减少AGEs积聚，降低血糖及炎性因子IL-6、IL-8、TNF-α的表达抑制糖尿病大鼠牙周炎的发展。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the effect of Puerarin Injection on periodontitis and expression of serum ages and inflammatory factors in diabetic rats. Methods: Ten rats were randomly selected as the normal control group, and another 40 rats were established as diabetic periodontitis rats. The rats were randomly divided into model group, experimental group and positive group, with 10 rats in each group. After 6 weeks of treatment, serum was taken to detect the expression of ages, IL-6, IL-8 and TNF-α; periodontal tissue was taken to observe the degree of alveolar bone loss. Results: Compared with the healthy control group, the insulin level of the model group was significantly decreased, the levels of blood glucose, ages, IL-6, IL-8 and TNF-α were significantly increased, and the height of alveolar bone reduction was significantly increased(P<0.05). Compared with the model group, the levels of blood glucose, ages, IL-6, IL-8 and TNF-α in the experimental group and positive group were significantly increased, and the height of alveolar bone was decreased (P<0.05). Conclusion: Puerarin injection can inhibit the development of periodontitis in diabetic rats by promoting the expression of insulin, reducing the accumulation of ages, reducing the expression of blood glucose and inflammatory factors IL-6, IL-8 and TNF-α. |
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