| 王 嘉,田东倩,魏英粉,杨泽垠,邸 斌.慢性鼻病中乏氧诱导因子与5-脂加氧酶表达变化及其与疾病严重程度关系研究[J].现代生物医学进展英文版,2021,(17):3285-3288. |
| 慢性鼻病中乏氧诱导因子与5-脂加氧酶表达变化及其与疾病严重程度关系研究 |
| Study on the Relationship between the Expression of Hypoxia-inducible Factor and 5-lipoxygenase in Chronic Nasal Diseases and the Severity of the Disease |
| Received:January 30, 2021 Revised:February 26, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.17.019 |
| 中文关键词: 慢性鼻病 乏氧诱导因子 5-脂加氧酶 |
| 英文关键词: Chronic Rhinopathy Hypoxia Inducible Factor 5-Lipoxygenase |
| 基金项目:2020年河北省卫健委青年科技基金项目(20200228) |
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| 中文摘要: |
| 摘要 目的：探究慢性鼻病中乏氧诱导因子（HIF-1α）与5-脂加氧酶（5-LOX）表达变化及其与疾病严重程度关系。方法：选取我院2019年7月-2020年11月期间收治的75例慢性鼻病患者作为研究对象；其中鼻息肉25例，变态反应性鼻炎25例，鼻窦炎25例；同期选择30例经鼻中隔偏曲矫正下鼻甲成形术患者的下鼻甲黏膜组织设为对照组。比较四组患者乏氧诱导因子与5-脂加氧酶蛋白及mRNA水平；并分析在不同鼻部疾病中，HIF-1α、5-LOX的相关性。结果：鼻息肉组、变态反应性鼻炎组、鼻窦炎组患者HIF-1α、5-LOX表达水平高于对照组（P<0.05）；鼻息肉组、变态反应性鼻炎组、鼻窦炎组患者HIF-1α、5-LOX表达水平比较无统计学意义（P>0.05）。鼻息肉组、变态反应性鼻炎组、鼻窦炎组患者HIF-1α、5-LOX mRNA表达水平高于对照组（P<0.05）；鼻息肉组、变态反应性鼻炎组、鼻窦炎组患者HIF-1α、5-LOX mRNA表达水平比较无统计学意义（P>0.05）。Parman相关分析，在不同鼻部疾病中，HIF-1α蛋白表达与5-LOX蛋白表达呈正相关（P<0.05）。结论：在慢性鼻病（鼻息肉、变态反应性鼻炎、鼻窦炎）中，HIF-1α、5-LOX表达水平显著升高，且在慢性疾病发展中可能相互促进、互相影响。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the changes in the expression of hypoxia-inducible factor (HIF-1α) and 5-lipoxygenase (5-LOX) in chronic nasal diseases and their relationship with the severity of the disease. Methods: From July 2019 to November 2020, 75 patients with chronic rhinopathy admitted to our hospital were selected as the research subjects; among them, 25 were nasal polyps, 25 were allergic rhinitis, and 25 were sinusitis; 30 cases of transnasal septum were selected during the same period. The inferior turbinate mucosal tissue of patients undergoing inferior turbinoplasty with curvature correction was set as the control group. Compare the levels of hypoxia-inducible factor and 5-lipoxygenase protein and mRNA in the four groups of patients; and analyze the correlation between HIF-1α and 5-LOX in different nasal diseases. Results: The expression levels of HIF-1α and 5-LOX in the nasal polyp group, allergic rhinitis group, and sinusitis group were higher than those in the control group(P<0.05); HIF-1α in the nasal polyp group, allergic rhinitis group, and sinusitis group The expression level of 5-LOX was not statistically significant(P>0.05). The expression levels of HIF-1α and 5-LOX mRNA in the nasal polyp group, allergic rhinitis group, and sinusitis group were higher than those in the control group (P<0.05); HIF- in the nasal polyp group, allergic rhinitis group, and sinusitis group The expression levels of 1α and 5-LOX mRNA were not statistically significant(P>0.05). Parman correlation analysis showed that HIF-1α protein expression was positively correlated with 5-LOX protein expression in different nasal diseases(P<0.05). Conclusion: In chronic nasal diseases (nasal polyps, allergic rhinitis, sinusitis), the expression levels of HIF-1α and 5-LOX are significantly increased, and they may promote and influence each other in the development of chronic diseases. |
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