| 谭 磊,朱勇军,谭清金,唐海涛,谢冰峰.术前预后营养指数与可切除非小细胞肺癌患者术后生活质量和远期预后的关系研究[J].现代生物医学进展英文版,2021,(17):3276-3280. |
| 术前预后营养指数与可切除非小细胞肺癌患者术后生活质量和远期预后的关系研究 |
| Relationship Study between Preoperative Prognostic Nutrition Index and Postoperative Quality of Life and Long-term Prognosis in Patients with Resectable Non-small Cell Lung Cancer |
| Received:February 02, 2021 Revised:February 23, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.17.017 |
| 中文关键词: 预后营养指数 非小细胞肺癌 生活质量 远期预后 影响因素 |
| 英文关键词: Prognostic nutritional index Non-small cell lung cancer Quality of life Long-term prognosis Influencing factors |
| 基金项目:湖南省自然科学基金面上项目（2017JJ2285） |
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| 中文摘要: |
| 摘要 目的：探讨术前预后营养指数（PNI）与可切除非小细胞肺癌（NSCLC）患者术后生活质量和远期预后的关系。方法：选择2015年2月-2017年2月期间我院收治的400例可切除NSCLC患者，根据术前PNI将患者分为高PNI组（PNI≥50，235例）和低PNI组（PNI＜50，165例）。患者术后住院期间生活质量采用健康状况调查简表（SF-36）评估。所有患者均采用门诊复查和电话随访的方式随访3年，Kaplan-Meier生存分析不同PNI指数下可切除NSCLC患者无进展生存期（PFS）生存率、总生存期（OS）生存率，Cox风险比例回归分析可切除NSCLC患者远期预后的影响因素。结果：高PNI组术后SF-36各项评分和总分，PFS生存率、OS生存率均高于低PNI组（P＜0.05）。多因素Cox风险比例回归分析显示TNM分期Ⅲa期、低PNI是可切除NSCLC患者远期预后的影响因素（P＜0.05）。结论：术前高PNI可切除NSCLC患者近期生活质量和远期生存率均高于低PNI者，术前PNI可能作为可切除NSCLC患者远期预后评估的辅助指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between preoperative prognostic nutrition index (PNI) and postoperative quality of life and long-term prognosis in patients with resectable non-small cell lung cancer (NSCLC). Methods: A total of 400 patients with resectable NSCLC who were admitted to our hospital from February 2015 to February 2017 were selected, and they were divided into high PNI group (PNI≥ 50, 235 cases) and low PNI group (PNI < 50, 165 cases) according to preoperative prognostic nutrition index (PNI). Quality of life during postoperative hospitalization was assessed using the 36-Item Short Form Health Survey (SF-36). All patients underwent outpatient reexamination and telephone follow-up for 3 years. Kaplan-Meier survival was analyzed for progression-free survival(PFS) and overall survival(OS) of patients with resectable NSCLC under different PNI indices, and Cox risk ratio regression was used to analyze the influencing factors for the long-term prognosis of patients with resectable NSCLC. Results: Postoperative SF-36 scores and total scores, PFS survival rate and OS survival rate in the high PNI group were higher than those in the low PNI group(P＜0.05). Multivariate Cox hazard ratio regression analysis showed that TNM stage Ⅲa stage and low PNI were the influencing factors for the long-term prognosis of patients with resectable NSCLC(P＜0.05). Conclusion: The short-term quality of life and long-term survival of patients with high preoperative PNI patients with resectable NSCLC are higher than those with low PNI. Preoperative PNI may be used as an auxiliary indicator for the long-term prognosis evaluation of patients with resectable NSCLC. |
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