| 王媛媛,王 亮,王云玲,郭 辉,刘珺迪,王金英.3.0 T磁共振T2×mapping成像技术定量评估膝关节骨性关节炎的临床价值及与WOMAC评分的相关性分析[J].现代生物医学进展英文版,2021,(17):3256-3259. |
| 3.0 T磁共振T2×mapping成像技术定量评估膝关节骨性关节炎的临床价值及与WOMAC评分的相关性分析 |
| Clinical Value of 3.0T Magnetic Resonance T2× Mapping for Quantitative Evaluation of Knee Osteoarthritis and Its Correlation Analysis with WOMAC Score |
| Received:December 28, 2020 Revised:January 23, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.17.012 |
| 中文关键词: 膝关节骨性关节炎 磁共振T2×mapping成像技术 西安大略和麦克马斯特大学骨关节炎指数 相关性 |
| 英文关键词: Knee osteoarthritis Magnetic resonance T2* mapping imaging technique McMaster University Osteoarthritis Index Correlation |
| 基金项目:新疆维吾尔自治区自然科学基金面上项目(2017D01C300) |
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| 中文摘要: |
| 摘要 目的：研究3.0 T磁共振T2×mapping成像技术定量评估膝关节骨性关节炎（OA）的临床价值及与西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分的相关性。方法：将我院于2017年4月～2019年12月期间收治的膝关节OA患者80例纳入研究。根据K-L分级标准将膝关节OA患者分成轻度组（K-L分级为Ⅰ～Ⅱ级）32例，重度组（K-L分级为Ⅲ～Ⅴ级）48例。另取同期于我院进行体检的健康者30例作为对照组。所有受试者均接受3.0 T磁共振T2×mapping扫描，比较各组膝关节不同部位软骨T2值、WOMAC评分以及血清炎症因子水平，以Pearson相关性分析膝关节OA患者膝关节不同部位软骨T2值和WOMAC评分的关系。结果：重度组膝关节不同部位软骨T2值均高于轻度组以及对照组，且轻度组膝关节不同部位软骨T2值均高于对照组（均P＜0.05）。重度组各项WOMAC评分及总分均高于轻度组以及对照组，且轻度组各项WOMAC评分及总分均高于对照组（均P＜0.05）。经Pearson相关性分析发现：膝关节OA患者膝关节不同部位软骨T2值和各项WOMAC评分及总分均呈正相关（均P＜0.05）。重度组血清白介素-1β（IL-1β）、白介素-18（IL-18）、肿瘤坏死因子α（TNF-α）均高于轻度组以及对照组，且轻度组血清IL-1β、IL-18、TNF-α均高于对照组（均P＜0.05）。结论：3.0 T磁共振T2×mapping成像技术定量评估膝关节OA的临床价值较高，且患者膝关节不同部位软骨T2值与WOMAC评分密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical value of 3.0T magnetic resonance T2×mapping in quantitative evaluation of knee joint osteoarthritis (OA) and its correlation with the McMaster University Osteoarthritis Index (WOMAC) score. Methods: 80 patients with knee OA who were admitted to our hospital from April 2017 to December 2019 were included in the study. According to K-L classification standard, the knee OA patients were divided into mild group (K-L class was Ⅰ ~ Ⅱ) with 32 cases and severe group (K-L class was Ⅲ ~ Ⅴ) with 48 cases. In addition, 30 healthy people who had physical examination with our hospital during the same period were taken as the control group. All subjects underwent 3.0T Magnetic resonance T2×mapping scan, the T2 value of cartilage in different parts of the knee joint, WOMAC score and serum inflammatory factors levels in each group were compared. Pearson correlation was used to analyze the relationship between the T2 value of cartilage in different parts of the knee joint and WOMAC score in patients with knee OA. Results: The T2 values of cartilage in different parts of knee joints in the severe group were all higher than those in the mild group and the control group, and the T2 values of cartilage in different parts of knee joints in the mild group were all higher than those in the control group (all P<0.05). All WOMAC scores in the severe group were higher than those in the mild group and the control group, and all WOMAC scores in the mild group were higher than those in the control group (all P<0.05). Pearson correlation analysis showed that T2 value of cartilage in different parts of knee joint in patients with knee OA was positively correlated with WOMAC score (all P<0.05). The serum Interleukin-1 β (IL-1 β), interleukin-18 (IL-18), tumor necrosis factor-α (TNF-α) in the severe group were all higher than those in the mild group and the control group, and the serum IL-1β, IL-18 and TNF-α in the mild knee were all higher than those in the control group (all P<0.05). Conclusion: 3.0T magnetic resonance T2×mapping has a high clinical value in quantitative evaluation of knee OA, and the T2 value of cartilage in different parts of knee joint in patients is closely related to WOMAC score. |
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