| 王 茜,白瑞苗,陈红雨,齐红艳,郭金珍.细菌性脑膜炎患儿脑脊液Caveolin-1、VE-cadherin、CXCl-5水平与炎性因子的关系及其诊断价值分析[J].现代生物医学进展英文版,2021,(16):3155-3159. |
| 细菌性脑膜炎患儿脑脊液Caveolin-1、VE-cadherin、CXCl-5水平与炎性因子的关系及其诊断价值分析 |
| Relationship between Levels of Caveolin-1, VE-cadherin, CXCl-5 in Cerebrospinal Fluid and Inflammatory Factors in Children with Bacterial Meningitis and Analysis of Its Diagnostic Value |
| Received:March 09, 2021 Revised:March 30, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.16.032 |
| 中文关键词: 细菌性脑膜炎 Caveolin-1 VE-cadherin CXCl-5 炎性因子 诊断价值 |
| 英文关键词: Bacterial meningitis Caveolin-1 VE-cadherin CXCl-5 Inflammatory factors Diagnostic value |
| 基金项目:陕西省重点研发计划项目（2018SF-070） |
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| 中文摘要: |
| 摘要 目的：探讨细菌性脑膜炎（BM）患儿脑脊液陷窝蛋白-1（Caveolin-1）、血管内皮钙黏素（VE-cadherin）、CXC类趋化因子配体5（CXCl-5）水平与炎性因子的相关性，分析Caveolin-1、VE-cadherin、CXCl-5诊断BM的价值。方法：选取2016年1月1日至2020年5月1日期间我院收治的106例BM患儿（BM组）、76例病毒性脑炎（VM）患儿（VM组）、72例无神经系统损伤患儿（对照组）。检测BM组、VM组患儿脑脊液中Caveolin-1、VE-cadherin、CXCl-5水平，检测三组血清肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）和C-反应蛋白（CRP）、白介素-6（IL-6）水平。Pearson相关性分析Caveolin-1、VE-cadherin、CXCl-5与TNF-α、PCT、CRP、IL-6之间相关性，受试者工作特征（ROC）曲线分析Caveolin-1、VE-cadherin、CXCl-5诊断BM的价值。结果：BM组脑脊液Caveolin-1、VE-cadherin、CXCl-5水平高于VM组（P＜0.05），血清TNF-α、PCT、CRP、IL-6水平高于VM组和对照组（P＜0.05），VM组血清TNF-α、PCT、CRP、IL-6水平高于对照组（P＜0.05）。BM组患儿脑脊液中Caveolin-1、VE-cadherin、CXCl-5水平与血清TNF-α、PCT、CRP、IL-6水平均呈正相关（P＜0.05）。ROC曲线分析结果显示联合Caveolin-1、VE-cadherin、CXCl-5诊断BM的曲线下面积（AUC）为0.888，高于以上指标单独诊断的0.690、0.661、0.639。结论：BM患儿脑脊液中Caveolin-1、VE-cadherin、CXCL5水平较VM患儿增高，其可能通过介导神经系统炎症反应参与BM发病，联合三项指标在BM鉴别诊断中具有较高价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between the levels of caveolin-1 (Caveolin-1), vascular endothelial calcherin (VE-cadherin), CXC-chemokine ligand 5 (CXCl-5) in cerebrospinal fluid and inflammatory factors in children with bacterial meningitis (BM), and to analyze the diagnostic value of Caveolin-1, VE-cadherin and CXCl-5 in BM. Methods: 106 cases of BM children (BM group), 76 cases of viral meningitis (VM group) and 72 cases of children without nervous system injury (control group) who were admitted to our hospital from January 1, 2016 to May 1, 2020 were selected. The levels of Caveolin-1, VE-cadherin and CXCl-5 in the cerebrospinal fluid of children in BM group and VM group were detected, and the levels of tumor necrosis factor-α (TNF-α), procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) in serum of the three groups were detected. Pearson correlation analyzed the relation between Caveolin-1, VE-cadherin, CXCl-5 and TNF-, PCT, CRP, IL-6 correlation. Receiver operating characteristic curve (ROC) analyzed the value of Caveolin-1, VE-cadherin and CXCl-5 in the diagnosis of BM. Results: The levels of Caveolin-1, VE-cadherin and CXCl-5 in cerebrospinal fluid in BM group were higher than those in VM group (P<0.05), the levels of serum TNF-α, PCT, CRP and IL-6 were higher than those in VM group and control group (P<0.05), and the levels of serum TNF-α, PCT, CRP and IL-6 in VM group were higher than those in control group (P<0.05). The levels of Caveolin-1, VE-cadherin and CXCl-5 in cerebrospinal fluid in BM group were positively correlated with the levels of serum TNF-α, PCT, CRP and IL-6 (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of combined Caveolin-1, VE-cadherin and CXCl-5 in diagnosis of BM was 0.888, which was higher than that of single diagnosis of above indicators of 0.690, 0.661, 0.639 respectively. Conclusion: The levels of Caveolin-1, VE-cadherin and CXCl5 in cerebrospinal fluid of children with BM are higher than those of VM, which may play a role in the pathogenesis of BM through mediating the inflammatory response of nervous system. Combined with these three indicators have high value in the differential diagnosis of BM. |
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