| 喻兰雅,寇晓梅,柯永莉,李 燕,李 黎.乳腺癌组织表皮生长因子受体、细胞角蛋白5/6、上皮钙黏蛋白表达与预后的关系研究[J].现代生物医学进展英文版,2021,(16):3079-3083. |
| 乳腺癌组织表皮生长因子受体、细胞角蛋白5/6、上皮钙黏蛋白表达与预后的关系研究 |
| Study on the Relationship between the Expression of Epidermal Growth Factor Receptor, Cytokeratin 5/6, Epithelial Cadherin and Prognosis in Breast Cancer Tissues |
| Received:February 23, 2021 Revised:March 18, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.16.016 |
| 中文关键词: 乳腺癌 表皮生长因子受体 细胞角蛋白5/6 上皮钙黏蛋白 预后 |
| 英文关键词: Breast cancer Epidermal growth factor receptor Cytokeratin 5/6 Epithelial cadherin Prognosis |
| 基金项目:广东省中医药局科研项目（20152030） |
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| 中文摘要: |
| 摘要 目的：探讨乳腺癌组织表皮生长因子受体(EGFR)、细胞角蛋白5/6(CK5/6)、上皮钙黏蛋白(E-Cad)表达与预后的关系。方法：选取我院(2015年1月～2017年12月)收治的100例接受乳腺外科手术治疗的乳腺癌患者，免疫组织化学检测乳腺癌组织和癌旁组织中EGFR、CK5/6、E-Cad表达。比较乳腺癌组织与癌旁组织中EGFR、CK5/6、E-Cad的阳性表达率，分析乳腺癌组织中EGFR、CK5/6、E-Cad表达与临床病理特征的关系，Kaplan-Meier曲线分析EGFR、CK5/6、E-Cad不同表达患者的无病生存期(DFS)和总生存期(OS)曲线，多因素Cox回归分析乳腺癌预后的影响因素。结果：乳腺癌组织中EGFR、CK5/6的阳性表达率明显高于癌旁组织，E-Cad的阳性表达率明显低于癌旁组织(P＜0.05)。乳腺癌组织中EGFR、E-Cad阳性表达率与分化程度、TNM分期相关(P＜0.05)，与年龄、肿瘤直径、病理类型无关(P＞0.05)；CK5/6阳性表达率与年龄、肿瘤直径、分化程度、TNM分期无关(P＞0.05)，与病理类型相关(P＜0.05)。Kaplan-Meier生存曲线显示，EGFR、CK5/6阳性表达患者3年DFS和OS明显低于阴性表达患者，E-Cad阳性表达患者3年DFS和OS明显高于阴性表达患者(P＜0.05)。多因素Cox回归分析显示，TNM分期Ⅲ期(HR=5.756，95%CI：1.535～21.591)、EGFR阳性(HR=8.090，95%CI：0.954～68.616)、CK5/6阳性(HR=4.507，95%CI：0.466～43.593)为乳腺癌预后独立危险因素，E-Cad阳性(HR=0.221，95%CI：0.048～1.020)为乳腺癌预后独立保护因素(P＜0.05)。结论：乳腺癌组织中EGFR、CK5/6表达明显升高，E-Cad表达明显降低，三者为乳腺癌患者预后独立影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of epidermal growth factor receptor (EGFR), cytokeratin 5/6 (CK5/6), epithelial cadherin (E-Cad) and prognosis in breast cancer tissues. Methods: A total of 100 breast cancer patients who underwent breast surgery were selected from our hospital (January 2015 to December 2017) were selected, immunohistochemistry was used to detect EGFR, CK5/6, E-Cad in breast cancer tissues and adjacent tissues expression. The positive expression rates of EGFR, CK5/6, E-Cad in breast cancer tissues and adjacent tissues were compared, the relationship between EGFR, CK5/6, E-Cad expression in breast cancer tissues and clinicopathological characteristics were analyzed. Kaplan-Meier curve was used to analyze the disease free survival (DFS) and overall survival (OS) curves of patients with different expression of EGFR, CK5/6 and E-Cad. Multivariate Cox regression analysis was used to analyze the prognostic factors of breast cancer. Results: The positive expression rates of EGFR and CK5/6 in breast cancer tissues were significantly higher than those in adjacent tissues, and the positive expression rate of E-Cad was significantly lower than that in adjacent tissues (P＜0.05). The positive expression rates of EGFR and E-Cad in breast cancer were correlated with differentiation degree and TNM stage (P＜0.05), but they were not related to age, tumor diameter and pathological type (P＞0.05). The positive expression rate of CK5/6 was not related to age, tumor diameter, differentiation degree and TNM stage (P＞0.05), but was related to pathological type (P＜0.05). Kaplan-Meier survival curve showed that 3-year DFS and OS of patients with positive expression of EGFR and CK5/6 were significantly lower than those with patients with negative expression. The 3-year DFS and OS of patients with E-Cad positive expression were significantly higher than those with patients with negative expression (P＜0.05). Multivariate Cox regression analysis showed that TNM stage III (HR=5.756, 95%CI: 1.535～21.591), EGFR positive (HR=8.090, 95%CI：0.954～68.616), CK5/6 positive (HR=4.507, 95%CI: 0.466～43.593) were independent risk factors for the prognosis of breast cancer, E-Cad positive (HR=0.221, 95%CI: 0.048～1.020) were independent protective factors for the prognosis of breast cancer (P＜0.05). Conclusion: The expressions of EGFR and CK5/6 in breast cancer tissues are significantly increased, and the expression of E-Cad is significantly decreased, which were independent influencing factors for the prognosis of patients with breast cancer. |
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