| 杨旭辉,夏杏芳,周志林,梅 勇,戴 军.急性胰腺炎患者血清PAB、HMGB1、SIL-2R、ACE2水平变化及意义[J].现代生物医学进展英文版,2021,(16):3054-3058. |
| 急性胰腺炎患者血清PAB、HMGB1、SIL-2R、ACE2水平变化及意义 |
| Analysis of the Changes and Significance of Serum PAB, HMGB1, sIL-2R, ACE2 Levels in Patients with Acute Pancreatitis |
| Received:January 23, 2021 Revised:February 18, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.16.011 |
| 中文关键词: 急性胰腺炎 前白蛋白 高迁移率族蛋白 B1 可溶性白介素2受体 紧张素转化酶2 |
| 英文关键词: Acute pancreatitis Prealbumin High mobility group protein B1 Soluble interleukin-2 receptor Tensin converting enzyme 2 |
| 基金项目:湖北省自然科学基金项目(2015CFB302) |
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| 中文摘要: |
| 摘要 目的：探讨急性胰腺炎患者血清前白蛋白（PAB）、高迁移率族蛋白 B1（HMGB1）、可溶性白介素2受体(SIL-2R)、紧张素转化酶2（ACE2）水平变化及意义。方法：选择2018年7月至2020年7月于我院进行治疗的急性胰腺炎患者83例患者进行研究，设为病例组，并选择我院同期体检健康者70例作为对照组，分析患者血清PAB、HMGB1、SIL-2R、ACE2及急性生理功能和慢性健康状况评分系统Ⅱ（APACHEII）评分水平变化情况及之间的相关性，采用受试者工作特征曲线分析血清PAB、HMGB1、SIL-2R、ACE2的诊断价值。结果：病例组患者血清PAB、ACE2水平显著低于对照组，HMGB1、SIL-2R、APACHEII评分水平显著高于对照组，差异显著（P＜0.05）；轻症组血清PAB、ACE2水平显著高于重症组，HMGB1、SIL-2R、APACHEII评分水平显著低于重症组，差异显著（P＜0.05）；Pearson相关分析结果显示，血清PAB、ACE2与APACHEⅡ之间呈负相关（P<0.05），血清HMGB1、SIL-2R与APACHEⅡ之间呈正相关（P<0.05）；血清PAB预测急性胰腺炎的临界值为147.09 mg/L，灵敏度为80.54%，特异度为85.68%，AUC为0. 845，血清HMGB1预测急性胰腺炎的临界值为85.34 ng/L，灵敏度为81.65%，特异度为86.69%，AUC为0. 998，血清SIL-2R预测急性胰腺炎的临界值为25.47 pg/mL，灵敏度为81.59%，特异度为87.57%，AUC为0. 978，血清ACE2预测急性胰腺炎的临界值为298.57 pg/mL，灵敏度为80.19%，特异度为83.58%，AUC为0. 867。结论：血清PAB、HMGB1、SIL-2R、ACE2的表达与APACHEII评分之间密切相关，对急性胰腺炎具有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study Analysis of the Changes and significance of serum Proalbumin (PAB), high mobility group protein B1 (HMGB1), soluble interleukin-2 receptor (sIL-2R), tensin converting enzyme 2 (ACE2) levels in patients with acute pancreatitis. Methods: 83 patients with acute pancreatitis who were treated in our hospital from July 2018 to July 2020 were selected as the case group, and 70 healthy people in our hospital during the same period were selected as the control group. The changes of serum PAB, HMGB1, sIL-2R, ACE2 and acute physiology and chronic health scoring system II (APACHE II) score levels and their correlation were analyzed The diagnostic value of serum PAB, HMGB1, sIL-2R and ACE2 was analyzed by receiver operating characteristic curve. Results: Serum PAB and ACE2 levels in case group were significantly lower than control group, and HMGB1, sIL-2R and ApacheII scores were significantly higher than control group, the differences were significant (P < 0.05). Serum PAB and ACE2 levels in mild disease group were significantly higher than those in severe disease group, and the levels of HMGB1, sIL-2R and ApacheII scores were significantly lower than those in severe disease group, with significant differences (P < 0.05). Pearson correlation analysis, according to the results of serum PAB, ACE2 with APACHE Ⅱ between negatively correlated (P < 0.05), serum HMGB1, SIL - 2 r and APACHE Ⅱ between positively correlated (P < 0.05); Serum PAB predict the critical value of acute pancreatitis is 147.09 mg/L, the sensitivity was 80.54%, 85.68%, AUC is 0. 845, serum HMGB1 predict the critical value of 85.34 ng/L of acute pancreatitis, the sensitivity was 81.65%, 86.69%, AUC is 0. 998, serum SIL - 2 r to predict the critical value of acute pancreatitis is 25.47 pg/mL, the sensitivity was 81.59%, 87.57%, AUC is 0. 978, The cut-off value of serum ACE2 for predicting acute pancreatitis was 298.57 pg/mL, the sensitivity was 80.19%, the specificity was 83.58%, and the AUC was 0. 867. Conclusion: The expression of PAB, HMGB1, sIL-2R and ACE2 in serum was closely correlated with ApacheII score, which had a high predictive value for acute pancreatitis. |
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