| 靳冬梅,伍东月,莹 杰,杜瑞亭,郭清民.青海地区46273例女性宫颈HPV检测结果分析[J].现代生物医学进展英文版,2021,(15):2982-2985. |
| 青海地区46273例女性宫颈HPV检测结果分析 |
| Analysis of HPV Test Results in 46273 Women in Qinghai Area |
| Received:December 23, 2020 Revised:January 18, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.15.038 |
| 中文关键词: 青海 宫颈 人乳头瘤病毒 高危亚型 |
| 英文关键词: Qinghai Cervical Human papilloma virus High-risk subtype |
| 基金项目:青海省卫健委2020年基础研究指导项目（2020-wjzdx-06） |
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| 中文摘要: |
| 摘要 目的：根据青海地区妇女宫颈人乳头瘤病毒（HPV）检测结果，分析宫颈高危HPV（HR-HPV）感染分布特点，为指导HPV疫苗接种提供理论依据。方法：采用Hybriuax技术检测21种高危型HPV亚型，对2014年1月-2020年2月于我院就诊的46273例女性宫颈人乳头瘤病毒分型检测。结果：46273例妇女中，高危HPV阳性率10.23%，高危HPV阳性率和年龄之间存在线性趋势，随年龄的增大感染比例上升。单一高危亚型HPV感染前三位的HPV亚型为16、58和39，合计占到45.64%。HPV亚型感染以单高危阳性为主，占总HPV阳性数的88.26%，占全部筛查人数的9.03%。HPV16、58、31、68亚型阳性率和年龄段之间存在线性趋势，随年龄的增大感染比例上升。HPV感染亚型检出构成比各年龄段均以HPV16感染排在第一位，排在第二位除61-70岁为双高危外，均为HPV58为主。结论：青海地区女性HPV感染率较高，以单一高危型感染为主，HPV16、58、39、52是主要的感染亚型，所以应针对青海地区HPV感染状况设计具有针对性的预防HPV感染亚型的疫苗。 |
| 英文摘要: |
| ABSTRACT Objective: According to the cervical human papillomavirus (HPV) detection results of women in Qinghai area, to analyze the distribution characteristics of cervical high-risk HPV (HR-HPV) infection and provide theoretical basis for the guidance of using HPV vaccination. Methods: The Hybriuax technology was used to detect 21 kinds of high-risk HPV subtypes, and the subtypes of HPV in 46,273 women visited our hospital from January 2014 to February 2020 was tested. Results: The positive rate of high risk HPV was 10.23% among 46,273 women. There was a linear trend between the patients' detection positive rate of high-risk HPV and age, and the infection rate increased with the increase of age. The top three HPV subtypes of single high-risk HPV infection were subtypes 16, 58 and 39, accounting for 45.64% in total. The majority HPV subtypes infection were single high-risk HPV detection positive, accounting for 88.26% of the total number of HPV positive, and 9.03% of the total number of people screened. The positive rates of HPV subtypes 16, 58, 31 and 68 showed a linear trend with age, and the infection rate increased with age. HPV-16 infection ranked first in all age groups, HPV-58 infection ranked second in all age groups except for those aged 61-70 who were with double high-risk HPV infection. Conclusion: Women in Qinghai area have a high rate of HPV infection, which is mainly caused by single high-risk infection, and subtypes 16, 58, 39 and 52 of high-risk HPV are the main infection subtypes. Therefore, according to the status of HPV infection in Qinghai, targeted vaccines should be designed to prevent HPV infection. |
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