| 康慧霞,邢建月,郭二华,邢大庆,郭晓霏.芪术胶囊联合穴位贴敷对糖尿病肾病Ⅲ-Ⅳ期患者血脂、肾功能和血清TGF-β1、CTGF水平的影响[J].现代生物医学进展英文版,2021,(15):2939-2942. |
| 芪术胶囊联合穴位贴敷对糖尿病肾病Ⅲ-Ⅳ期患者血脂、肾功能和血清TGF-β1、CTGF水平的影响 |
| Effect of Qizhu Capsule Combined with Acupoint Application on Blood Lipid, Renal Function and Serum TGF-β1, CTGF Levels in Patients with Diabetic Nephropathy Stage Ⅲ-Ⅳ |
| Received:February 03, 2021 Revised:February 28, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.15.029 |
| 中文关键词: 芪术胶囊 穴位贴敷 糖尿病肾病 Ⅲ-Ⅳ期 血脂 肾功能 TGF-β1 CTGF |
| 英文关键词: Qizhu capsule Acupoint application Diabetic nephropathy Stage Ⅲ-Ⅳ Blood lipid Renal function TGF-β1 CTGF |
| 基金项目:山西省科技厅科技攻关计划（141078） |
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| 中文摘要: |
| 摘要 目的：观察芪术胶囊联合穴位贴敷对糖尿病肾病（DN）Ⅲ-Ⅳ期患者血脂、肾功能和血清转化生长因子-β1（TGF-β1）、结缔组织生长因子（CTGF）水平的影响。方法：选择2018年3月~2020年8月期间我院收治的DN患者90例，将患者按随机数字表法分为对照组（n=45）和研究组（n=45），对照组予以常规西医治疗，研究组在对照组的基础上给予芪术胶囊联合穴位贴敷治疗，均治疗4周。比较两组患者的疗效、中医证候积分、血脂、肾功能和血清TGF-β1、CTGF水平。结果：治疗4周后，研究组的临床总有效率88.89%（40/45）高于对照组68.89%（31/45）（P<0.05）。治疗4周后，研究组中医证候积分、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL）、血肌酐（Scr）、血尿素氮（BUN）、TGF-β1、CTGF、尿白蛋白排泄率（UAER）低于对照组（P<0.05），高密度脂蛋白（HDL）高于对照组（P<0.05）。结论：芪术胶囊联合穴位贴敷治疗DN Ⅲ-Ⅳ期患者，可有效改善患者血脂及肾功能，促进症状缓解，降低血清TGF-β1、CTGF水平。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effect of Qizhu capsule combined with Acupoint Application on blood lipid, renal function and serum levels of transforming growth factor-β1(TGF-β1) and connective tissue growth factor(CTGF) in patients with diabetic nephropathy (DN) at stage Ⅲ-Ⅳ. Methods: 90 patients with DN in our hospital from March 2018 to August 2020 were selected, and they were randomly divided into control group(n=45) and study group(n=45). The control group was treated with conventional western medicine, and the study group was treated with Qishu capsule combined with Acupoint Application on the basis of the control group, with 4 weeks of treatment. The curative effect, TCM syndrome score, blood lipid, renal function, serum TGF-β1 and CTGF levels were compared between the two groups. Results: After 4 weeks of treatment, the total effective rate of the study group was 88.89% (40/45), which was higher than 68.89% (31/45) of the control group (P<0.05). After 4 weeks of treatment, the TCM syndrome score, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), serum creatinine (SCR), blood urea nitrogen (BUN), TGF-β1, CTGF and urinary albumin excretion rate (UAER) of the study group were lower than those of the control group(P<0.05), and the high density lipoprotein (HDL) of the study group was higher than that of the control group (P<0.05). Conclusion: Qizhu capsule combined with acupoint application can effectively improve the blood lipid and renal function of patients with DN stage Ⅲ-Ⅳ, promote the remission of symptoms, and reduce the levels of serum TGF-β1 and CTGF. |
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