| 谢 佳,胡 晓,夏宛廷,罗玉炜,任爱玲.加味补中益气汤治疗肥胖型多囊卵巢综合征患者的疗效及对子宫内膜容受性和糖脂代谢的影响[J].现代生物医学进展英文版,2021,(15):2931-2934. |
| 加味补中益气汤治疗肥胖型多囊卵巢综合征患者的疗效及对子宫内膜容受性和糖脂代谢的影响 |
| Efficacy of Jiawei Buzhong Yiqi Decoction on Obese Polycystic Ovary Syndrome and Its Influence on Endometrial Receptivity and Glucose and Lipid Metabolism |
| Received:December 27, 2020 Revised:January 21, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.15.027 |
| 中文关键词: 加味补中益气汤 多囊卵巢综合征 疗效 子宫内膜容受性 糖脂代谢 |
| 英文关键词: Jiawei Buzhong Yiqi decoction Obese polycystic ovary syndrome Efficacy Endometrial receptivity Glucose and lipid metabolism |
| 基金项目:成都中医药大学附属医院/四川省中医院科技发展基金项目（18ZX02）；四川省高等学校人文社会科学重点研究基地"四川中医药文化协同发展研究中心"2020年度项目（2020WH036）；四川省科技厅苗子工程项目（2018105） |
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| 中文摘要: |
| 摘要 目的：探讨加味补中益气汤治疗肥胖型多囊卵巢综合征（PCOS）患者的疗效及对子宫内膜容受性和糖脂代谢的影响。方法：选择2018年3月~2020年5月期间我院收治的肥胖型PCOS患者280例，采用抽签法分为观察组140例和对照组140例。对照组给予二甲双胍片治疗，观察组给予加味补中益气汤治疗，对比两组疗效、体质量指数（BMI）、腰臀比、性激素指标[雌二醇（E2），促黄体生成激素（LH）、卵泡刺激素（FSH）]、子宫内膜容受性指标[子宫内膜厚度、子宫内膜螺旋动脉搏动指数（PI）与阻力指数（RI）]、糖脂代谢指标[总胆固醇(TC)、低密度脂蛋白 (LDL-C)、甘油三酯(TG)、高密度脂蛋白 (HDL-C)、空腹血糖（FPG）]。结果：观察组的临床总有效率为92.14%（129/140），高于对照组的80.71%（113/140）（P<0.05）。治疗3个月经周期后，两组BMI、腰臀比、PI、RI、LH、FSH、TC、LDL-C、TG、FPG均下降，且观察组低于对照组（P<0.05）。治疗3个月经周期后，两组子宫内膜厚度、HDL-C、E2升高，且观察组高于对照组（P<0.05）。结论：加味补中益气汤治疗肥胖型PCOS患者，可降低患者体质量，调节性激素、子宫内膜容受性和糖脂代谢水平，具有较好的疗效。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of Jiawei Buzhong Yiqi decoction on obese polycystic ovary syndrome (PCOS) and its influence on endometrial receptivity and glucose and lipid metabolism. Methods: 280 cases of obese PCOS in our hospital from March 2018 to May 2020 were selected, they were divided into observation group (140 cases) and control group (140 cases) by drawing lots. The control group was treated with metformin tablets, while the observation group was treated with Jiawei Buzhong Yiqi decoction. The efficacy, body mass index (BMI), waist hip ratio, sex hormone indexes [estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH)], endometrial receptivity indexes [endometrial thickness, endometrial spiral artery pulsatility index (PI) and resistance index (RI)], glucose and lipid metabolism indexes [total cholesterol (TC), low density lipoprotein (LDL-C), triglyceride (TG), high-density lipoprotein (HDL-C), fasting plasma glucose (FPG)] were compared between the two groups. Results: The clinical total effective rate of the observation group was 92.14% (129 / 140), which was higher than 80.71% (113/140) of the control group(P<0.05). 3 menstrual cycles after treatment, BMI, waist hip ratio, PI, RI, LH, FSH, TC, LDL-C, TG and FPG of the two groups decreased, and the observation group was lower than the control group(P<0.05). 3 menstrual cycles after treatment, endometrial thickness, HDL-C and E2 in the two groups increased, and the observation group was higher than the control group(P<0.05). Conclusion: In the treatment of obese PCOS patients, Jiawei Buzhong Yiqi decoction can reduce body weight, regulate sex hormone, endometrial receptivity and glucose and lipid metabolism, and which has a good curative effect. |
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