| 李 狱,杨 晶,孙永峰,王 毅,马凯骅.射频消融术对胃癌肝转移患者胃肠功能、DOK3、DOK2水平的影响[J].现代生物医学进展英文版,2021,(15):2893-2896. |
| 射频消融术对胃癌肝转移患者胃肠功能、DOK3、DOK2水平的影响 |
| Effect of Radiofrequency Ablation on Gastrointestinal Function, Dok3 and Dok2 Levels in Patients with Liver Metastasis of Gastric Cancer |
| Received:February 02, 2021 Revised:February 25, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.15.019 |
| 中文关键词: 射频消融术 胃肠功能 DOK3 DOK2 |
| 英文关键词: Radiofrequency ablation gastrointestinal function DOK3 DOK2 |
| 基金项目:国家自然科学基金面上项目（81470060） |
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| 中文摘要: |
| 摘要 目的：探讨射频消融术对胃癌肝转移患者胃肠功能、酪氨酸激酶下游蛋白（downstream of tyrosinekinase3, DOK3）、酪氨酸激酶下游蛋白（downstream of tyrosinekinase2, DOK2）水平的影响。方法：选取2017年1月-2020年10月我院收治的90例胃癌肝转移患者作为研究对象，随机将其分为两组，对照组45例，给予原发灶和肝转移切除手术治疗；研究组45例，给予肝转移灶射频消融术治疗，观察两组患者的疗效及并发症率，检测治疗后两组患者胃肠功能、DOK3、DOK2水平。结果：研究组的治疗有效率为88.89 %，高于对照组的71.11 %（P＜0.05）；研究组患者腹胀腹痛缓解时间、肠鸣音恢复时间、排气时间、排便时间均短于对照组的相应时间（P＜0.05）；两组患者手术前DOK3、DOK2低表达率对比无明显差异（P＞0.05），手术后，研究组患者DOK3、DOK2低表达率明显低于对照组，差异具有统计学意义（P＜0.05）；研究组患者的并发症发生率为11.11 %，低于对照组的26.67 %（P＜0.05）；两组患者复发率对比无统计学差异（P＞0.05）。结论：对于胃癌肝转移患者采取射频消融术治疗，其效果明显优于传统手术，可促使胃肠功能恢复，改善DOK3、DOK2的表达水平， 降低并发症风险发生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of radiofrequency ablation on gastrointestinal function, down stream of tyrosine kinase 3 (DOK3) and down stream of tyrosine kinase 2(DOK2) levels in patients with liver metastasis of gastric cancer. Methods: 90 cases of gastric cancer patients with liver metastasis admitted to our hospital from January 2017 to October 2020 were selected as the research objects and randomly divided into two groups. The control group (45 cases) was given resection of primary tumor and liver metastasis; the study group(45 cases) was given radiofrequency ablation of liver metastasis. The curative effect and complication rate of the two groups were observed, and the gastrointestinal function, DOK3 and DOK2 levels of the two groups were detected after treatment. Results: The effective rate of the study group was 88.89 %, higher than 71.11 % of the control group (P<0.05); the remission time of abdominal distension and pain, recovery time of bowel sounds, exhaust time and defecation time of the study group were shorter than those of the control group(P<0.05); there was no significant difference in the low expression rate of DOK3 and DOK2 between the two groups before operation After operation, the low expression rates of DOK3 and DOK2 in the study group were significantly lower than those in the control group(P<0.05); the incidence of complications in the study group was 11.11 %, lower than 26.67 % in the control group(P<0.05); there was no statistical difference in the recurrence rate between the two groups(P>0.05). Conclusion: For patients with liver metastasis of gastric cancer, radiofrequency ablation has a better effect than traditional surgery. It can promote the recovery of gastrointestinal function, improve the expression level of DOK3 and DOK2, and reduce the risk of complications. |
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