| 才 让,阿选德,祁蕙燕,张 辉,赵 莹.非小细胞肺癌患者循环肿瘤细胞与血清SCC-Ag及Cy-fra21-1水平的关系研究[J].现代生物医学进展英文版,2021,(14):2778-2781. |
| 非小细胞肺癌患者循环肿瘤细胞与血清SCC-Ag及Cy-fra21-1水平的关系研究 |
| Relationship between Circulating Tumor Cells and Serum Scc-ag and Cy-fra21-1 Levels in Patients with NSCLC |
| Received:November 24, 2020 Revised:December 18, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.14.038 |
| 中文关键词: 非小细胞肺癌 循环肿瘤细胞 鳞状细胞癌抗原 角质素19可溶片段 |
| 英文关键词: Non-small cell lung cancer Circulating tumor cells Squamous cell carcinoma antigen Keratin 19 soluble fragments |
| 基金项目:青海省自然科学基金项目（2015-ZJ-203） |
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| 中文摘要: |
| 摘要 目的：研究非小细胞肺癌（NSCLC）患者循环肿瘤细胞（CTC）数与血清鳞状细胞癌抗原（SCC-Ag）及角质素19可溶片段（Cy-fra21-1）水平的关系。方法：将从2017年2月～2019年2月我院收治的NSCLC患者100例纳入研究，记作NSCLC组。另取同期我院收治的100例肺良性病变患者作为良性病变组。再取同期于我院进行体检的健康志愿者100例作为对照组。检测并比较三组人员的CTC数和血清SCC-Ag、Cy-fra21-1水平，并以Pearson相关性分析CTC数和血清SCC-Ag、Cy-fra21-1水平的关系。通过受试者工作特征（ROC）曲线分析CTC和血清SCC-Ag、Cy-fra21-1诊断NSCLC的效能。此外，分析CTC和血清SCC-Ag、Cy-fra21-1与NSCLC患者淋巴结转移的关系。结果：NSCLC组及良性病变组的CTC数以及血清SCC-Ag、Cy-fra21-1水平均高于对照组，且NSCLC组CTC数以及血清SCC-Ag、Cy-fra21-1水平均高于良性病变组（P＜0.05）。经Pearson相关性分析发现：NSCLC患者CTC数和血清SCC-Ag、Cy-fra21-1水平均呈正相关（r=0.642、0.601，P＜0.05）。经ROC曲线分析可得：CTC和血清SCC-Ag、Cy-fra21-1联合检测诊断NSCLC的曲线下面积、灵敏度、特异度较上述指标单独检测高（P＜0.05）。NSCLC淋巴结转移患者的CTC数和血清SCC-Ag、Cy-fra21-1水平均高于无淋巴结转移患者（P＜0.05）。结论：NSCLC患者CTC数与血清SCC-Ag及Cy-fra21-1水平存在明显正相关，三者联合检测可更加准确的诊断NSCLC，且上述三项指标可能和NSCLC患者淋巴结转移密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between circulating tumor cells (CTC) and serum scc-ag and keratin 19 soluble fragment (cy-fra21-1) levels in patients with non-small cell lung cancer (NSCLC). Methods: 100 NSCLC patients admitted to our hospital from February 2017 to February 2019 were included in the study, which was referred to as NSCLC group. Another 100 patients with benign lung lesions admitted to our hospital at the same time were taken as the benign lesion group. Another 100 healthy volunteers who underwent physical examination in our hospital at the same time were selected as the control group. The CTC and serum scc-ag and cy-fra21-1 levels of the three groups were detected and compared, and the correlation between CTC and serum scc-ag and cy-fra21-1 levels was analyzed by Pearson correlation. The diagnostic efficacy of CTC and serum scc-ag and cy-fra21-1 levels in NSCLC was analyzed by ROC curve. In addition, the relationship between CTCS, serum scc-ag, cy-fra21-1 and lymph node metastasis in NSCLC patients was analyzed. Results: The levels of CTC, serum scc-ag and cy-fra21-1 in the NSCLC group and the benign lesion group were higher than those in the control group, and the levels of CTC, serum scc-ag and cy-fra21-1 in the NSCLC group were higher than those in the benign lesion group (all P<0.05). Pearson correlation analysis showed that there was a positive correlation between CTC and serum scc-ag and cy-fra21-1 levels in NSCLC patients (r=0.642、0.601, P<0.05). According to ROC curve analysis, the combined detection of CTC, serum scc-ag and cy-fra21-1 levels in the diagnosis of NSCLC showed that the area under the curve, the sensitivity and the specificity were all higher than those measured separately (all P<0.05). The levels of CTC and serum scc-ag and cy-fra21-1 in patients with NSCLC lymph node metastasis were higher than those in patients without lymph node metastasis (all P<0.05). Conclusion: There is a significant positive correlation between CTCS and serum scc-ag and cy-fra21-1 levels in NSCLC patients, and the combined detection of the three can improve the diagnostic value of NSCLC, and the above three indicators are closely related to lymph node metastasis. |
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