| 丁灿群,张盛强,张云海,高群兴,谭啟恩.针灸、推拿及中药外敷对腰椎间盘突出的临床疗效及血清TXB2、IL-1β、IL-10水平对比[J].现代生物医学进展英文版,2021,(14):2730-2734. |
| 针灸、推拿及中药外敷对腰椎间盘突出的临床疗效及血清TXB2、IL-1β、IL-10水平对比 |
| Clinical Effect of Acupuncture, Massage and External Application of Traditional Chinese Medicine on Lumbar Disc Herniation and Comparison of Serum TXB2, IL-1β and IL-10 Levels |
| Received:January 31, 2021 Revised:February 26, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.14.028 |
| 中文关键词: 针灸 推拿 中药外敷 腰椎间盘突出 临床疗效 炎症反应 |
| 英文关键词: Acupuncture Massage External application of traditional Chinese Medicine Lumbar disc protrusion Clinical effect Inflammatory reaction |
| 基金项目:广东省中医药局2021年度科研项目（20211369） |
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| 中文摘要: |
| 摘要 目的：研究针灸、推拿及中药外敷对腰椎间盘突出的临床疗效及血清血栓素（thromboxane，TXA2）、白细胞介素-1β （Interleukin-1β）、白细胞介素-10 （Interleukin-10 IL-10）水平对比。方法：选取2019年1月至2020年12月的80例腰椎间盘突出患者。按照随机数表法分为观察组（n=41）和对照组（n=39），对照组采用中药外敷治疗，观察组采用针灸、推拿及中药外敷联合治疗。对比两组治疗效果，治疗前后日本骨科协会评估治疗分数（Japanese Orthopaedic Association Scores JOA）、视觉模拟评分法（visual analogue scale VAS）评分情况变化，血清TXB2、IL-1β、IL-10水平变化，腰椎功能及腰部关节活动度，不良反应发生率。结果：治疗后，观察组总有效率显著高于对照组[95.12%（39/41）vs71.79％（28/39）]（P＜0.05）；JOA显著高于对照组[（23.19±3.21）分vs（17.62±2.65）分]（P<0.05），VAS评分显著低于对照组[（2.07±0.38）分vs（3.58±0.61）分]（P<0.05）；血清TXB2、IL-1β水平均显著低于对照组[（24.37±3.26）μg/L vs（34.08±4.72）μg/L，（0.12±0.03）ng/L vs（0.27±0.05）ng/L]（P<0.05）；血清IL-10水平显著低于对照组[（85.82±7.03）pg/mL vs（57.28±6.31）pg/mL]（P<0.05）；功能障碍指数（Oswestry disability index）显著低于对照组[（37.81±6.23）％ vs（68.02±8.91）％]（P<0.05）；腰部关节活动度显著高于对照组[（80.36±0.82）° vs（71.27±0.6）°]（P<0.05）；两组不良反应对比无显著差异（P>0.05）。结论：针灸、推拿及中药外敷对腰椎间盘突出的临床疗效显著，可有效改善患者的临床症状，缓解疼痛，抑制炎症因子TXB2、IL-1β表达，促进抗炎因子IL-10水平升高，安全有效。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect of acupuncture, massage and external application of traditional Chinese medicine on lumbar disc herniation and comparison of serum TXB2, IL-1 β and IL-10 levels. Methods: 80 lumbar disc protrusion who received therapy from January 2019 to December 2020 in our hospital were selected as research objects. According to random number table，those patients were divided into the observation group (n=41) and the control group (n=39). The control group was treated with external application of traditional Chinese medicine. The observation group was treated with acupuncture, massage and external application of traditional Chinese medicine. The therapeutic effects, JOA and VAS scores, serum TXB2, IL-1 β and IL-10 levels, lumbar function and lumbar joint range of motion, and the incidence of adverse reactions were compared between the two groups. Results: After treatment, The total effective rate of observation group was significantly higher than that of control group[95.12%(39/41) vs 71.79％(28/39)](P＜0.05). JOA was significantly higher than that of the control group[(23.19±3.21)scores vs (17.62±2.65)scores](P＜0.05). VAS score was significantly lower than that of the control group[(2.07±0.38)scores vs（3.58±0.61）scores] (P＜0.05). The levels of TXB2 and IL-1 β in serum were significantly lower than those in control group [(24.37±3.26) μg/L vs (34.08±4.72) μg/L, (0.12±0.03) ng/L vs (0.27±0.05) ng/L] (P＜0.05). Serum IL-10 level was significantly lower than that of the control group[(85.82±7.03) pg/mL vs (57.28±6.31) pg/mL] (P<0.05). Oswestry score was significantly lower than that of the control group[(37.81±6.23)％ vs(68.02±8.91)％] (P<0.05). The range of motion of the lumbar joint was significantly higher than that of the control group[(80.36±0.82)° vs(71.27±0.6）°] (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion: Acupuncture, massage and external application of traditional Chinese medicine have significant clinical effect on lumbar disc herniation, which can effectively improve the clinical symptoms of patients, relieve pain, inhibit the expression of inflammatory factors TXB2 and IL-1 β, and promote the level of anti-inflammatory factor IL-10, which is safe and effective. |
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