| 李仁武,刘宝利,纪利梅,常 静,申正日.肾衰宁颗粒联合甘精胰岛素对糖尿病肾病患者肾功能、血糖及氧化应激的影响[J].现代生物医学进展英文版,2021,(14):2726-2729. |
| 肾衰宁颗粒联合甘精胰岛素对糖尿病肾病患者肾功能、血糖及氧化应激的影响 |
| Effects of Shenshuaining Granules Combined with Insulin Glargine on Renal Function, Blood Glucose and Oxidative Stress in Patients with Diabetic Nephropathy |
| Received:January 06, 2021 Revised:January 29, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.14.027 |
| 中文关键词: 糖尿病肾病 肾衰宁颗粒 甘精胰岛素 氧化应激 血糖 肾功能 |
| 英文关键词: Diabetic nephropathy Shenshuaining granules Insulin glargine Oxidative stress Blood glucose Renal function |
| 基金项目:北京市中医药科技发展基金资助项目（JJ2012-20） |
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| 中文摘要: |
| 摘要 目的：探究糖尿病肾病患者采用肾衰宁颗粒联合甘精胰岛素治疗对氧化应激、血糖水平以及肾功能产生的影响。方法：将我院95例糖尿病肾病患者视为研究对象，分为对照组（47例，甘精胰岛素治疗）、观察组（48例，肾衰宁颗粒联合甘精胰岛素治疗），对照组仅采用甘精胰岛素治疗，观察组采用肾衰宁颗粒联合甘精胰岛素治疗，对比两组临床疗效、治疗前后肌酐清除率（CCr）、肌酐（Scr）、尿素氮（BUN）、24h尿蛋白（24 hUP）、糖化血红蛋白（HbA1c）、空腹血糖（FBG）、餐后2h血糖（2 hPG）、谷胱甘肽过氧化物酶（GSH -Px）、超氧化物歧化酶（SOD）、丙二醛（MDA）水平与不良反应发生情况。结果：观察组治疗总有效率较对照组高（P＜0.05）；两组不良反应发生率对比无差异（P＞0.05）；与治疗前比较，两组治疗后CCr水平提高，24 hUP、SCr、BUN水平均降低（P＜0.05）；与对照组比较，观察组治疗后24 hUP、SCr、BUN水平更低，CCr水平更高（P＜0.05）；与治疗前比较，两组治疗后MDA水平均降低，SOD、GSH -Px水平均提高（P＜0.05）；与对照组比较，观察组治疗后MDA水平更低，SOD、GSH -Px水平更高（P＜0.05）。结论：糖尿病肾病患者采用肾衰宁颗粒联合甘精胰岛素治疗疗效明确，可减轻机体氧化应激状态，改善肾功能与血糖，且用药安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Shenshuaining granules combined with insulin glargine treatment on oxidative stress, blood glucose level and renal function in patients with diabetic nephropathy. Methods: 95 patients with diabetic nephropathy admitted in our hospital were selected as the research object. And they were divided into control group (47 cases, treated with insulin glargine), and observation group (48 cases, treated with shenshuaining granules combined with insulin glargine). The clinical efficacy, creatinine clearance rate (CCr), creatinine (Scr), urea nitrogen (BUN), 24h urinary protein (24hUP), glycated hemoglobin (HbA1c), fasting blood glucose (FBG), 2h postprandial blood glucose (2hPG), glutathione peroxidase (GSH-Px), superoxide Dismutase (SOD), malondialdehyde (MDA) levels before and after treatment and the occurrence of adverse reactions of two groups were compared. Results: The total effective rate of treatment in observation group was higher than control group (P<0.05). There was no difference in the incidence of adverse reactions in two groups(P>0.05). Compared with before treatment, CCr level was increased, 24hUP, SCr and BUN levels in both groups after treatment were decreased(P<0.05). Compared with the control group, the 24hUP, SCr and BUN levels in the observation group after treatment were decreased, and CCr level was increased (P<0.05). Compared with before treatment, MDA level in both groups after treatment was decreased, and SOD and GSH-PX levels were increased (P<0.05). Compared with the control group, MDA level in the observation group after treatment was lower, and SOD and GSH-PX levels were higher (P<0.05). Conclusion: In patients with diabetic nephropathy, Shenshuining Granule combined with insulin glargine has a definite therapeutic effect, which can reduce the oxidative stress state of the body, improve renal function and blood sugar, and the drug is safe. |
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